New study out yesterday suggesting that vaccine efficacy with current dose for 5-11 yr olds likely wanes quickly. Especially against infection, but also against hospitalisation, although protection against severe disease is higher. Seems to be closely linked to vaccine dose🧵 
Vaccine dose is the same as adult in 12-17 yr olds but much lower in 5-11 yr olds. There is a clear dose-response, with response greatest in 12 yr olds (greatest dose/wt) & graded lowering for other age gps. For 5-11 yr we see rapid decline in effectiveness against infection.
Effectiveness against hospitalisations also declined from 100% early on to ~48% 6 wks later, which is a significant decline. Suggests we need dose adjustments/vaccine updates against omicron/boosting to ensure a good response in this age group.
Meanwhile mitigations are key to maintain in schools and in the community to protect children from long COVID and other impacts of infection. And vital to maintain suppression of the virus to prevent new variants evolving - omicron has been a game changer for vaccine efficacy.
Study here:
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
Sorry, deleted earlier tweet on the Guardian article because there was an inaccuracy in the article that I hadn't initially picked up on. Have reposted this thread with original study instead.
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