This is educational in nature and not medical or dietetic advice. See terms on my web site for additional and more complete disclaimers.
Blood cholesterol levels, along with LDL particle count, ApoB concentration, LDL particle size, LDL pattern, and the ratio of cholesterol between LDL and HDL are all governed centrally by the LDL receptor.
About 29 million American adults, adolescents, and children are on selective serotonin reuptake inhibitors (SSRIs). In many countries globally some 5-10% of the population are on SSRIs. These have become the first-line treatment for depression.
SSRIs can cause sexual dysfunction and emotional blunting in up to half of people, an unclear incidence of sleep disruption, and a rare risk of suicidality, self-harm, and new-onset psychosis.
This doesn't directly cause depression, but if you have depressing thoughts, emotions, and thought patterns, it makes them harder to let go of because the mind is too sticky.
This is why their are multiple randomized controlled trials showing methylation support decreases depression scores and why it is included in my depression protocol.