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Chris Masterjohn Profile picture
@ChrisMasterjohn
Mar 2, 2022 • 10 tweets • 3 min read • Read on X
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Holy shit, look at the redactions made in this Pfizer document.

phmpt.org/wp-content/upl…

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More from @ChrisMasterjohn

Chris Masterjohn Profile picture
Sep 30
Depressed and can't stop ruminating?

Here's the science behind how methylation can make your brain less "sticky."
There are two pools of dopamine in your brain, the tonic pool and the phasic pulses.

PMID: 15305167
The tonic pool is the background level and can be likened to sea level.

It is regulated by methylation. Image
Read 33 tweets
Chris Masterjohn Profile picture
Sep 28
An inability to stop ruminating is driven by insufficient methylation of dopamine, which makes the brain too "sticky."
This doesn't directly cause depression, but if you have depressing thoughts, emotions, and thought patterns, it makes them harder to let go of because the mind is too sticky.
This is why their are multiple randomized controlled trials showing methylation support decreases depression scores and why it is included in my depression protocol.
Read 6 tweets
Chris Masterjohn Profile picture
Sep 27
Beat From Depression Without SSRIs or Other Drugs

The ultimate how-to guide to obtain resilient mental health while boosting mitochondrial function instead of strangling it.

🧵👇 Image
The first-line treatment for depression in modern society is SSRIs, but long-term SSRI use can cause sexual dysfunction, it can cause severe mitochondrial dysfunction in a rare subset of people...
...and years-long SSRI use leads to severe withdrawal syndromes becoming common and often leads to new-onset mitochondrial function that lasts years.
Read 26 tweets
Chris Masterjohn Profile picture
Sep 23
The mechanism of Tylenol toxicity is most likely inducing mitochondrial function by depleting mitochondrial glutathione and occurs biochemically at any dose.

🧵👇
Acetaminophen (paracetamol, N-acetyl-p-aminophenol, APAP) is used by 50 million American adults per week but in high doses contributes to centrilobular necrosis that results in 10,000 hospital visits and 500 deaths per year, accruing direct costs of almost $90 million annually [5, 7].
The mechanisms of acetaminophen-induced hepatic necrosis have been reviewed in [7], listed at end.
Read 30 tweets
Chris Masterjohn Profile picture
Sep 4
I hate to break it to you, but your favorite "evidence-based pyramid" guru learned about evidence-based medicine from a meme.

Yes, the pyramid is a meme. If it's what you know about evidence-based medicine, you are the Sesame Street character of evidence.
For example, this is a meme. Image
This also is a meme. Image
Read 14 tweets
Chris Masterjohn Profile picture
Sep 1
What Everyone Should Be Doing For Their Health

Make sure you're keeping up with the basics.

🧵 Image
There are basic things we should all be doing for good health.
You may be struggling to improve a problem and making little progress.
Read 25 tweets

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