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Chris Masterjohn Profile picture
Chris Masterjohn
@ChrisMasterjohn
Mitochondrial health expert applying peer-reviewed science to develop evidence-based protocols for human health and longevity. Founder of https://t.co/p1KbY9pqx8.
30 subscribers
Sep 30 • 33 tweets • 6 min read
Depressed and can't stop ruminating?

Here's the science behind how methylation can make your brain less "sticky." There are two pools of dopamine in your brain, the tonic pool and the phasic pulses.

PMID: 15305167
Sep 28 • 6 tweets • 1 min read
An inability to stop ruminating is driven by insufficient methylation of dopamine, which makes the brain too "sticky." This doesn't directly cause depression, but if you have depressing thoughts, emotions, and thought patterns, it makes them harder to let go of because the mind is too sticky.
Sep 27 • 26 tweets • 4 min read
Beat From Depression Without SSRIs or Other Drugs

The ultimate how-to guide to obtain resilient mental health while boosting mitochondrial function instead of strangling it.

🧵👇 Image The first-line treatment for depression in modern society is SSRIs, but long-term SSRI use can cause sexual dysfunction, it can cause severe mitochondrial dysfunction in a rare subset of people...
Sep 23 • 30 tweets • 4 min read
The mechanism of Tylenol toxicity is most likely inducing mitochondrial function by depleting mitochondrial glutathione and occurs biochemically at any dose.

🧵👇 Acetaminophen (paracetamol, N-acetyl-p-aminophenol, APAP) is used by 50 million American adults per week but in high doses contributes to centrilobular necrosis that results in 10,000 hospital visits and 500 deaths per year, accruing direct costs of almost $90 million annually [5, 7].
Sep 4 • 14 tweets • 3 min read
I hate to break it to you, but your favorite "evidence-based pyramid" guru learned about evidence-based medicine from a meme.

Yes, the pyramid is a meme. If it's what you know about evidence-based medicine, you are the Sesame Street character of evidence. For example, this is a meme. Image
Sep 1 • 25 tweets • 3 min read
What Everyone Should Be Doing For Their Health

Make sure you're keeping up with the basics.

🧵 Image There are basic things we should all be doing for good health.
Aug 9 • 7 tweets • 2 min read
Your cells are aging faster than you think.

After age 18, mitochondrial density declines by 1% every year—one of the clearest biological markers of aging.

By 70, you’ve lost more than half your cellular energy capacity.

Here’s what most people miss: this decline isn’t inevitable. 🧵👇 This test measures how well your mitochondria actually work—and gives you a precise protocol to fix what's aging you faster than you should be. Image
Jul 14 • 86 tweets • 10 min read
SSRIs Are Mitochondrial Drugs

Installment six in our series on understanding the truth about SSRIs.

🧵 Image Our series has so far focused on serotonin and melatonin but now turns to SSRIs themselves.
Jul 12 • 59 tweets • 7 min read
Your Mitochondria and the Two Faces of Serotonin

Installment five in our series on understanding the truth about SSRIs.

🧵 Image In our series on how to understand the truth about serotonin, SSRIs, SSRI side effects, and the sometimes devastating effects of SSRI withdrawal...
Jul 8 • 80 tweets • 9 min read
How Serotonin Helps You Breathe

Installment four in our series on understanding the truth about SSRIs.

🧵 Image We cannot understand what SSRIs are really doing without understanding how serotonin is impacting mitochondrial energy metabolism.
Jul 8 • 71 tweets • 7 min read
Serotonin in the Mitochondria Means Your Cells Are Fighting to Survive

Installment three in our series on understanding the truth about SSRIs.

🧵 Image The next installment in our series on the true nature of SSRIs gets into the true nature of serotonin and its powerful impact on energy metabolism.
Jul 6 • 40 tweets • 6 min read
Melatonin Is Your Mitochondria's Guardian Angel

Installment two in our series on understanding the truth about SSRIs.

🧵 Image As our story moves on from the first installment in our journey toward understanding why Prozac is a performance-enhancing drug, why people who use SSRIs often develop sexual dysfunction...
Jul 5 • 33 tweets • 6 min read
Prozac is a Performance-Enhancing Drug

🤔

What they never tell you about SSRIs.👇

🧵 Image We kick off this series on the real truth about SSRIs by making the seemingly wild observation that Prozac is a performance-enhancing drug in mice.
Jul 3 • 11 tweets • 3 min read
I have over twenty pages written that will make every doctor who ever prescribed an SSRI tremble at how little they understood the fire they were playing with. Stay tuned this week. Installment 1:
Jul 2 • 65 tweets • 8 min read
Nausea and Vomiting of Pregnancy Is Mitochondrial Dysfunction

The fascinating intersection between pregnancy and mitochondrial dysfunction and what to do about it.

🧵 Image Nausea and vomiting of pregnancy is a hypersensitive reaction to mitochondrial dysfunction in the mother in order to avert greater mitochondrial dysfunction in the more sensitive baby.
Jul 1 • 43 tweets • 5 min read
Introducing Mitome

Determine your "mitochondrial type" with my first-in-kind direct-to-consumer respiratory chain test that generates a personalized protocol. Image I'm excited to launch the first direct-to-consumer mitochondrial respiratory chain analysis and you can order it ​here​:

mito.me
Apr 19 • 8 tweets • 2 min read
The foundational origin myth of the "vaccines don't cause autism" cult is the retraction of the "fraudulent" Wakefield paper.

Just like Stalin erased Trotsky from photos of him and Lenin, they erase from history the larger 1996 Fudenberg paper that was never retracted. Published two years before Wakefield's paper, Fudenberg found that in 15 out of 22 autistics enrolled between 1984 and 1987, onset was within one week of the MMR vaccine. Image
Apr 13 • 35 tweets • 6 min read
Methylene Blue on the Airplane

…or underwater.

🧵 Image I talked to someone last night who said he uses methylene blue under two circumstances:
Apr 7 • 102 tweets • 11 min read
The Worst Longevity Idea Ever Conceived

The last thing you want to do is perpetually inhibit your mTOR.

🧵 Image Rapamycin is a darling of the longevity community.

I find it very hard to read the literature on this molecule without shuddering at the idea of taking it to lengthen lifespan.
Apr 3 • 21 tweets • 3 min read
My Oxalate Protocol

Oxalate causes crystals in the kidney, breasts, and brain, and is a powerful mitochondrial toxin that almost certainly shortens your lifespan and destroys your healthspan.

🧵 Image Do you have autism or have a friend or family member who has autism?

Oxalate levels are three times higher in autistics.
Mar 13 • 44 tweets • 6 min read
Why I Don't Care About Zone 2 Cardio

And what I do instead.

🧵 Image In 2022, inspired by Peter Attia’s interviews with Inigo San Millan, I experimented with measuring my lactate during exercise to calibrate my cardio to zone 2.