Biochemical Individualist. Master of practical biology. Organismal and cellular energy maxxer. Entropy disrespecter. PhD in Nutritional Sciences.
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Apr 23 • 16 tweets • 3 min read
Seed oils do not cause oxidative stress.
They increase vulnerability to oxidative damage.
Failure to distinguish between these two concepts leads to extreme misunderstandings, driving pointless debates and horrible takes on the existing intervention trials.
Oxidative stress is best defined as the dysregulation of redox-regulated pathways driving harmful but necessary compensations.
Apr 22 • 12 tweets • 2 min read
The reason glucose spikes create endothelial dysfunction that is preventable with vitamin C is that at glucose concentrations rise beyond what can be stored as glycogen or oxidized at the moment, glucose is converted to sorbitol using NADPH, which is what you need to recycle glutathione and vitamin C.
If we look at where sorbitol production tends to take place, it corresponds to about 144 mg/dL or 8 mmol/L.
PMID 35380232
Mar 11 • 35 tweets • 4 min read
The Problem With Coconut
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If you're not a Pacific Islander, your genes may not be compatible with a 63% coconut diet.
Mar 8 • 66 tweets • 8 min read
Will Longevity Diets Wreck Your Hormones?
Without the right nutrients they might even shorten your lifespan!
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One study in mice compared standard lab chow to calorie restriction, a fasting-mimicking diet (FMD), a ketogenic diet, a diet low in branched-chain amino acids (BCAAs) and two diets that restricted sulfur amino acids (SAAs) by either 80% or 100%.
Feb 29 • 38 tweets • 5 min read
Are Seed Oils Behind Your Oxalate Problem?
Probably. 🧵
Oxalate is a mitochondrial toxin that suppresses the citric acid cycle by 48% at the upper end of the normal range found in human blood, so if you feel like crap all the time you might have a problem with high oxalate levels.
Feb 22 • 64 tweets • 6 min read
Overcome OCD With Walking Sensory Meditation
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In the summer of 2022 when finishing two ebooks I realized that I could be dramatically more effective if I could spend 4-6 weeks of unbroken deep work without taking any days off, and then take off all the weekends I owed myself back-to-back in a road trip.
Feb 21 • 49 tweets • 8 min read
The new "protein is bad for your arteries" paper implies we have to choose between a healthy body composition and a healthy heart.
This cannot possibly be true.
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Feb 15 • 61 tweets • 12 min read
Much of what is claimed about lengthening lifespan in the longevity spaces comes from highly questionable animal models.
A thread 🧵👇
Do we live a longer life by going into a state of dormancy, like the famous worm, C. elegans?
Feb 9 • 42 tweets • 6 min read
Renal physiologists believe that citrate is alkalinizing because it is "rapidly metabolized to bicarbonate," but this makes no biochemical sense.
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Burton David Rose, the creator of Up-To-Date, and Theodore Post, the current Editor In Chief of Up-To-Date, co-authored textbook, Clinical Physiology of Acid-Base and Electrolyte Disorders.
Jan 31 • 38 tweets • 5 min read
The mitochondrial nutrient missing from every supplement is the respiratory chain component you never learned about in school.
A thread 🧵 👇
I searched “mitochondrial” on Amazon and accepted its suggested search of “mitochondrial support,” then looked at the first 50 supplements that came up and examined their labels to see if any had MK-4. One had MK-7 at a very modest dose of 100 micrograms, and none had any MK-4.
Jan 9 • 12 tweets • 2 min read
David Sinclair says SIRT3 activators boost mitochondrial function.
Too much of a good thing can be bad, and overactivation of SIRT3 destroys mitochondrial function.
Case in point: paraplegin deficiency causing heriditary spastic paraplegia.
The benefit of aspirin over the massive numbers of herbal salicylates and other COX inhibitors is that aspirin's acetyl group acetylates COX and promotes active switching from pro-inflammation mediators to pro-resolution mediators that clean up the inflammation.
BUT...
The traditional Chinese medicine Huo-Lou-Xiao-Lin Dan (HLXL) has three COX inhibitors with acetyl groups, Acetyl-11-keto-β-boswellic acid, β-boswellic acid, acetyl-α-boswellic acid, acetyl-β-boswellic acid.
Flu vaccines are not tested according to their ability to make you not get sick or get less sick.
They are tested for their ability to generate a negative PCR test among people who are equally sick.
Don’t ask me, ask @mlipsitch who reviewed the topic here:
The 3 things @bryan_johnson is missing from his longevity routine, coming from a PhD with over 20 years of research into nutrition science and biomarkers.
A thread 🧵👇
Johnson’s goal is to use the research of his team on promising published anti-aging strategies to incorporate them into his own stack, test them on himself, and use the vast resources at his disposal to bring the best anti-aging hacks to the masses.
Dec 15, 2023 • 97 tweets • 12 min read
Biochemistry textbooks say we cannot convert fatty acids, in net, to glucose.
They are wrong. A thread 🧵👇
Biochemistry textbooks generally tell us that we can't turn fatty acids into glucose. For example, in Biochemistry by Berg, Tymoczko, and Stryer, we find the following:
Dec 15, 2023 • 33 tweets • 4 min read
Methylation is about WAY more than B12 and folate. You have to consider at least 26 nutrients and hundreds of different genetic impairments.
A thread 🧵👇
MTHFR’s job is to use riboflavin (in the form of FAD) to take electrons from niacin (in the form of NADPH) to add them to what becomes the methyl group of methylfolate, which then gets passed on to vitamin B12, which then passes it to homocysteine to make methionine.
Dec 12, 2023 • 13 tweets • 2 min read
Interpreting the Genova Methylation Panel
This is hands down the best test, but you need to go beyond the interpretive section of the report to see all the patterns.
The widespread claims in the nutrition and longevity spaces that there is no safe level of alcohol consumption are total nonsense. A thread 🧵👇
In the study widely claimed to show that there is no safe level of alcohol for the brain, going from zero to one alcohol unit (half a drink per day) was not associated with any harm in females, and was associated with slightly better brain markers in males.
Nov 24, 2023 • 6 tweets • 1 min read
If you don’t notice yourself dreaming or your dreams aren’t very vivid, you’re probably deficient in B6 or zinc.
I added B6 and started having very vivid dreams, and then realized I had not noticed that I hadn’t been dreaming for a while.
Jun 23, 2023 • 101 tweets • 16 min read
The forward to Hotez’s book about why vaccines didn’t make his daughter autistic, written by Arthur L Caplan says that vitamins are “useless nostrums whose advocates “don’t seem to hear the viruses and bacteria laughing at them.”
audible.com/pd/1541449819?…
He cites the American Academy of Pediatrics as compiling evidence “firmly showing” there are no links between autism and MMR, thimerosal, or vaccine-induced febrile illness or seizures.
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