There is also a major difference in the vaccines used. Hong Kong used a high proportion of Sinovac, which has been shown to be less protective vs Omicron /4
This new report from Hong Kong shows the reduced neutralization and marked waning of CoronaVac compared with a mRNA vaccine vs Omicron thelancet.com/journals/ebiom…@TheLancet /5
The US should particularly take note of the situation in Hong Kong and its high vulnerability.
It tracks with boosters close to Hong Kong and ranks 55th in the world by countries /6
The UK and many European countries have now reached 3-dose vaccination rates of >90% for people 65+ assets.publishing.service.gov.uk/government/upl…
But the US is at 66% for boosters among this high risk age group /7
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We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And that leads to a unified model to pull it all together. (open-access)
I review 4 new reports, summarized here: 1. The proteins from senescent cells predict age-related clinical outcomes 2. A new epigenetic age clock connects the dots between aging, the immune system, inflammation and lifestyle factors 3. People with a fast pace of aging had an increased risk of cognitive impairment, age-related diseases, disability, and mortality 4. The Importance of “Immune Resilience” for Healthspan
And present a unified I/I model for what we now know
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)
A major @Nature paper this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones in a new Ground Truths (link in profile)
A Table from the post
The effect in the 2 natural experiments differed substantially by sex with the benefit predominant in women
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @Nature nature.com/articles/s4158… nature.com/articles/d4158…
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine
These are the specific foods that were linked with healthy aging and other outcomes. Green-favorable; Red-unfavorable
Adherence to these diets (most to least in quintiles) linked to healthy aging
A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access
I review the background and major implications in a new Ground Truths edition (link in my profile)nature.com/articles/s4159…
The human brain:
—had 7-30 times more accumulation of microparticles (MPs) than the liver or kidney (organs with previously documented high propensity)
—from people with dementia had 5X accumulation of MPs compared with non-dementia
—there was a marked increase of accumulation over recent years