If you actually review the unbiased literature on seed oils (not your little food guru blog articles, actual studies), this is exactly what those papers suggest is harmful, rather than seed oils inherently.
The Japanese eat a good amount of seed oils to compose their fat macro dietary intake, along with saturated fats in meats, O3 fats in seafood, and carbohydrates from rice, etc.
Pretty excellent longevity all things considered.
Most also eat much less fast food than the West.
Black seed oil has been consumed for a few thousand years, but never refried. Curious.
Now I’m not saying to go crazy with cooking/consuming industrialized vegetable/seed oils, just offering a newer perspective on the matter. Getting you to think beyond what others tell you to think.
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Estrogen in itself is pro-GABA and neuroprotective. Estrogen dominance or, more accurately, the imbalance between hormones, metabolites, and neurosteroids is anti-GABA or excitatory. A handful of the estrone metabolites is more specifically anti-GABA.
Serotonin is both inhibitory and excitatory depending on receptor and subreceptor unit site binding, typically tending towards more inhibitory, or pro-GABA. Hence why increasing it is effective in cases of obsessive-compulsive disorder and anxiety.
Nitric oxide in itself is pro-GABA, peroxynitrites without being effectively neutralized or recycled are anti-GABA.
This has been researched and common knowledge since the 1970s - 1980s. Not really so common anymore, of course. It’s not as profitable as a lifetime pharmaceutical prescription.
This is another major reason why I recommend investing in term insurance if you choose to ignore circadian rhythm and light environment.
Disturbed circadian rhythm of the intrarenal renin-angiotensin system: relevant to nocturnal hypertension and renal damage link.springer.com/article/10.100…