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Mar 9 7 tweets 5 min read
Congratulations to @demishassabis, John Jumper, and David Baker who will be awarded the Wiley Foundation 20th annual Wiley Prize in Biomedical Sciences on April 1: dpmd.ai/Wiley-Prize 🧵 1/7
Demis and John accept the award on behalf of the @DeepMind team who worked on #AlphaFold, which was recognised as a solution to the “protein folding problem” at CASP14 in Nov 2020: dpmd.ai/casp14_blog 2/7
From the start, we committed to giving broad access to our work and, in July 2021, we published our methods in @Nature along with the open source code.

Paper: dpmd.ai/alphafold-meth…
Open Source: dpmd.ai/alphafold-gith… 3/7 Image
A week later, we launched the AlphaFold Protein Structure Database, in partnership with @emblebi - more than doubling the number of high-accuracy human protein structures available. Over 400,000 researchers have already used it: dpmd.ai/alphafolddb 4/7
In October 2021 we launched AlphaFold-Multimer, which properly accounts for multi-chain proteins (complexes): dpmd.ai/alphafold-mult… 5/7 Image
And in January 2022 we added 27 new proteomes (190k+ proteins) to the database, 17 of which represent Neglected Tropical Diseases that continue to devastate the lives of more than 1 billion people globally: dpmd.ai/NTD 6/7 Image
A huge congratulations to the whole team who made this breakthrough happen! Check out our AlphaFold timeline for further info: dpmd.ai/AFtimeline 7/7 Image

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More from @DeepMind

Sep 29, 2021
From packing an umbrella to preparing for extreme conditions, predicting short term weather patterns is crucial for daily life.

New research with the @metoffice and SOTA model advances the science of Precipitation Nowcasting - the prediction of rain: dpmd.ai/nowcasting 1/4
Today’s weather systems provide planet-scale predictions several days ahead, but often struggle to generate high-resolution predictions for short lead times. Nowcasting fills this performance gap, with predictions on rainfall within the next 1-2 hours. 2/4
Compared to widely used-nowcasting methods, meteorologists from @metoffice rated this method as their 1st choice 89% of the time.

There's more to do but our researchers hope this will act as a base for future work & promote greater integration of ML & environmental science. 3/4
Read 4 tweets
Sep 9, 2021
Introducing the '21 DeepMind x @ai_ucl Reinforcement Learning Lecture Series, a comprehensive introduction to modern RL.

Follow along with our researchers are they explore Markov Decision Processes, sample-based learning algorithms & much more: dpmd.ai/2021RLseries 1/2 Image
Also find the full series via the DeepMind @YouTube channel: dpmd.ai/DeepMindxUCL21
In the first lecture of the series, Research Scientist Hado introduces the course and explores the fascinating connection between reinforcement learning and artificial intelligence: dpmd.ai/RLseries1

#DeepMindxUCL @ai_ucl Image
Read 10 tweets
Jul 27, 2021
Reinforcement learning typically trains & tests agents on the same game. New work shows how our team trains generally capable agents on huge game spaces, resulting in agents that generalise to held-out test games, & learn behaviours like experimentation dpmd.ai/open-ended-blog 1/
Rather than training on a limited number of tasks, our team defines a whole universe of tasks that can be procedurally generated, from simple object finding games to complex strategic games like Capture the Flag. 2/
By constructing a hierarchical learning process with an open-ended and iteratively refined objective, it was possible to train agents that never stop learning, and develop increasingly general behaviour across games. 3/
Read 5 tweets
Jul 26, 2021
Mixed Integer Programming is an NP-hard optimisation problem arising in planning, logistics, resource allocation, etc.

Presenting a solver with neural heuristics that learns to adapt to the problem domain, outperforming SCIP on Google-scale MIPs: dpmd.ai/13349 (1/) Image
Practical applications often focus on finding good solutions fast rather than proving optimality. In follow-up work, Neural Neighborhood Selection finds better solutions even faster by learning heuristics for large neighborhood search: dpmd.ai/10201 (2/) Image
The neural solver learns even on single problem instances, improving the best known solutions to three open MIPLIB problems.

Milo-v12-6-r1-75-1: dpmd.ai/milo-v12-6-r1-…
Neos-1420790: dpmd.ai/neos-1420790
xmas10-2: dpmd.ai/xmas10-2

(3/) Image
Read 4 tweets
Jul 23, 2021
Yesterday we announced early collaborations using the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome to date. So how is AlphaFold helping these organisations with their work…? 1/ Image
The Drugs for Neglected Diseases initiative (@DNDi) has advanced their research into life-saving cures for diseases that disproportionately affect the poorer parts of the world. 2/ Image
The @CEI_UoP is using #AlphaFold's predictions to help engineer faster enzymes for recycling some of our most polluting single-use plastics. 3/ Image
Read 4 tweets
Jul 22, 2021
Today with @emblebi, we're launching the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome, doubling humanity’s accumulated knowledge of high-accuracy human protein structures - for free: dpmd.ai/alphafolddb 1/
We’re also sharing the proteomes of 20 other biologically-significant organisms, totalling over 350k structures. Soon we plan to expand to over 100 million, covering almost every sequenced protein known to science & the @uniprot reference database.

dpmd.ai/alphafold-blog 2/
We’re excited to see how this will enable and accelerate research for scientists around the world. We've already seen promising signals from early collaborators using #AlphaFold in their own work, including @DNDi, @CEI_UoP, @UCSF & @CUBoulder: dpmd.ai/alphafold-case… 3/
Read 5 tweets

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