Hannah Davis Profile picture
Mar 10, 2022 17 tweets 6 min read Read on X
There's a big reality gap right now between people who are actively staying on top of COVID research & those who just trust the current guidelines. There's no judgment here, but I'd like to try to communicate the worldview of the former based on what we know about COVID now:

1/
The US has chosen to prioritize the economy despite strong, countless studies that COVID harms many people, even those without #LongCovid or hospitalization. COVID predominantly affects the *vascular* system (the blood vessels), causing harm to the blood cells & blood flow;

2/
this has a downstream impact on nerves, immune system, & multiple organs, including the brain. Vaccination prevents against death, but not against long term damage.

3/
Your first COVID infection can leave you with pre-existing conditions that will make you more vulnerable to subsequent infections. #LongCovid

If COVID circulates forever, you will be more vulnerable with every year that goes by.

4/
There is no permanent protection from this, neither from vaccination not infection. Having some immunity does not prevent damage on subsequent infections. COVID infections can impact fertility in all genders, making conceiving harder and causing more miscarriages.

5/
Even having *non-hospitalized* COVID increases the risk of 18 severe vascular conditions, including strokes, heart failure, clots, embolisms.

COVID can cause reactivated EBV, which is associated with lymphomas, multiple sclerosis, and other health issues.

6/
COVID can cause severe cognitive issues and brain changes in people who had never been hospitalized. There is no evidence that this resolves; many have had this for 2 years. Past SARS resulted in the same.

These are just a few examples. There are thousands. Harm is not rare.

7/
There is no real evidence that COVID will evolve to become less dangerous over time, but there is evidence to suggest it will become more dangerous especially given the amount of spread and ability to create new variants.

8/
Behind the scenes, all of this is acknowledged. Researchers, including at NIH, have acknowledged a likely wave of early onset dementia. The WHO & CDC meet with patients regularly & acknowledge the severity & future consequences.

9/
But there is no public awareness that just having COVID in itself is a huge health risk for your future, even from a "mild" infection, even if you feel recovered.

10/
For those of us who are up to date on COVID impacts, including breakthroughs & reinfections, it genuinely looks like we are going to kill or disable an enormous % of our population in the next 10 years, & our leaders have decided to intentionally keep people in the dark.

11/
And spoiler alert - the disability from COVID is *already* hurting the economy, and this will get worse every year too.

12/

ft.com/content/33444f…
As always, if you or a family member have health issues from COVID, I recommend joining the @itsbodypolitic support group, and @patientled for current research.

13/
I'm (slowly) going to add citations to this thread as I have brain space. A bunch to start:

COVID's vascular impact (google "endothelial dysfunction" for more):
*thelancet.com/journals/lanre…
*npr.org/sections/healt…
*mayoclinicproceedings.org/article/S0025-…

14/
Waning immunity both infection & vaccination (& booster):
*cdc.gov/mmwr/volumes/7…
*thelancet.com/journals/lanmi…
*nature.com/articles/d4158…

16/
COVID increases the risk of 18 vascular conditions in non-hospitalized patients (20 in hospitalized patients):

nature.com/articles/s4159…

17/

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More from @ahandvanish

Oct 12
Incredible visit Thursday to the opening of Mount Sinai’s Cohen Center for Recovery from Complex Chronic Illness, led by the renowned @PutrinoLab! #LongCovid 1/ Sign that says Cohen Center for Recovery from Complex Chronic illness
David Putrino in the center, masked, showing off tools used for metabolic and mitochondrial dysfunction
The Center is incredible and truly blew me away - designed on so many levels with patients in mind, with top notch care, using many of the most advanced tools available 2/
Some of the many tools patients are assessed with include:

-EndoPat (endothelial dysfunction)
-tilt table (dysautonomia)
-transcranial Doppler (cerebral blood flow)
-machine that identifies metabolic & mitochondrial dysfunction
-eeg & cognitive battery

3/
Read 8 tweets
Aug 28
Major paper! The team found that fibrinogen (which converts to fibrin):

-binds to spike
-forms clots + neuro issues
-acute stage fibrinogen = predictive biomarker of #LongCovid cog dysfunction!
-suppresses natural killer (NK) cells (which clear virus!)
1/nature.com/articles/s4158…
The fibrin also:
-promotes neuroinflammation & neuronal loss post infection
-promotes innate immune activation in the brain & lungs independent of active infection
-downregulated JAK-STAT pathway & targets of p38 MAP kinase, pathways that regulate NK cell activation #LongCovid 2/
They used a monoclonal antibody targeting the fibrin domain, and found it protected against microglial activation & neuronal injury, as well as from thromboinflammation in the lung after infection! #LongCovid 3/
Read 5 tweets
Jul 11
I've been doing #TheNicotineTest (via 7mg patches) for a month now & it has greatly improved my quality of life.

Major caveat: I'm on ivabradine. The nicotine increases heart rate, & I wouldn't recommend to anyone w POTS who isn't on beta-blockers or ivabradine. #LongCovid 1/
The biggest change is feeling like I have more *oxygen* circulating in my body - the weird altitude-sickness feeling is lessened.

Major improvements to cognition/awareness (esp executive functioning & processing), and improved physical capacity and overall baseline. 2/
The first tolerance break I felt more air hunger and worse baseline than pre-nicotine, but every other tolerance break has been equal or better than pre-nicotine.

It feels like an excellent symptom management tool, but *not* a cure. 3/
Read 7 tweets
May 1
From the Conference of Retroviruses & Opportunistic Infections: persistence of Covid in megakaryocytes in #LongCovid.

Over my head, but my understanding: megakaryocytes (type of bone marrow cell) being infected = continuous infection, very serious!

1/ croiconference.org/wp-content/upl…
graph showing levels of circulating Megakaryocytes; very low for healthy controls, high for severe Covid and Long Covid
This could cause additional impacts like deficits in platelet energy metabolism, or hormonal dysregulation (because platelets carry serotonin) #LongCovid

More about this here from the amazing @polybioRF!

2/polybio.org/projects/sars-…
The study found:

-circulating megakaryocytes harbored Spike, SARS-CoV-2 ssRNA, & dsRNA in #LongCovid patients

-these produced platelets containing Spike & SARS-CoV-2 ssRNA 3/
Read 5 tweets
Oct 30, 2023
Because this video has caused so much willful misinterpretation, I want to clarify: in the clip I’m countering the myth that #longcovid is lingering symptoms of acute COVID, since many people think it’s just a cough. I should‘ve said “acute COVID”; brain fogged & trying my best.
The interview was an hour long & they edited it to 5 min. I talked their ear off about all hypotheses & the science behind each & it didn’t make it in - the piece was for a general audience. I talked about all the other things COVID can cause, include diabetes & clots, at length.
Anyone who is suggesting I don’t think #longcovid is from COVID (????) or that I don’t think viral persistence is a high priority hypothesis (????) are *actively* ignoring 3.5 yrs of advocacy & that I’ve been highlighting viral persistence since 2020
Read 7 tweets
Sep 20, 2023
The most exciting hypotheses in #LongCovid and #pwME are ones that could have cures! This includes viral persistence and others, and also includes the itaconate shunt hypothesis. I'm going to tweet this video as I watch it to try to explain it more 1/
Dr. Ron Davis used to work on the Human Genome Project but switched to ME/CFS when his son got sick. He's the director at the Stanford Genome Center. He is focused on *a cure* for ME/CFS. "I believe it is a curable disease." 2/ slide that says "ME/CFS - A curable disease?"
He describes the common onsets of ME - usually viral, but can have other causes too, refers to a big parasite onset in Norway from a few years ago 3/ Image
Read 13 tweets

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