Thread by @LC_UK_Action

🚨 Molecular mimicry/Aabs driving #LongCovid ?: a🧵
An underrepresented area of LC study which may reveal real answers @NIHRresearch
Tissues, cells & processes affected: clotting, arteries, cardiac, respiratory, brainstem & ANS, mitochondria, thyroid, neurons and many more. 🧵1

'We found SARS-CoV-2 antibodies had reactions with 28 of 55 tissue antigens..incl barrier proteins, gastrointestinal, thyroid and neural tissues, and more...homology with the human tissue antigens mitochondria M2, F-actin and TPO' 🧵2
frontiersin.org/articles/10.33…

'Mimicry of multiple human proteins by SARS-CoV-2...expressed in arteries, lungs, esophagus, pancreas, and macrophages..HLA-A*03 restricted 8-mer peptides are shared broadly..with primary expr of the mimicked human proteins in neurons and immune cells'🧵3
biorxiv.org/content/10.110…

'The involvement of the protein E in provoking an autoimmune response (after the destruction of the virus particle) seems to be highly likely'🧵4
nature.com/articles/s4159…

'We found that the dorsal motor nucleus, nucleus ambiguus, nodose ganglion, and jugular ganglion can all host neurons presenting proteins with epitopes in common with SARS-CoV-2 proteins,' 🧵5
thelancet.com/journals/lanmi…

'We hypothesize that anosmia, leukopenia, and vascular damage with multi-organ damage are associated with molecular mimicry' 🧵6
sciencedirect.com/science/articl…

'damage to the respiratory pacemaker in the brainstem, also known as pre-Bötzinger complex (preBötC) [9], might contribute to respiratory failure in COVID-19 as a consequence of mimicry between viral and neuronal proteins of the preBötC' 🧵7
sciencedirect.com/science/articl…

'we have identified eight SARS-CoV-2-associated cases of anti-NMDA receptor encephalitis. All had cerebrospinal fluid antibodies against the NMDA receptor and a recent onset of working memory deficits, altered mental status, or psychiatric symptoms' 🧵8
jneuroinflammation.biomedcentral.com/articles/10.11…

'Antibodies cross-reacting with thrombopoietin may induce thrombocytopenia...Antibodies cross-reacting with PRKG1 and tropomyosin may cause known COVID-19 complications such as blood-clotting disorders and cardiac disease, respectively.'🧵9
europepmc.org/article/ppr/pp…

From an experimental perspective, results warrant the testing of patients’ sera for autoantibodies against these protein targets. Clinically, results warrant a stringent surveillance on the future pathologic sequelae of the current SARS-CoV-2 pandemic
🧵10
mdpi.com/2073-4468/9/3/3

Molecular mimicry drives the pathogenesis of autoimmune neuropathies such as Guillain-Barré syndrome and multiple sclerosis...SARS-CoV-2 found to share EIPKEE and DKKKK hexapeptides with and HSP60 and HSP 90 (HSP90B and HSP90B2) respectively
🧵11
immunopaedia.org.za/breaking-news/…

I reviewed just a few papers here but would be interested in opinions, my brain just is NOT what it used to be...@Daltmann10 @dbkell @doctorasadkhan @fitterhappierAJ @VirusesImmunity it's a disparate mix of findings but they jive with clinical pres and many findings to date...

@NIHRresearch @AMannanBaig might be an interesting read for you too 😘