Yet, in recent interviews, these authors continue to assert that all sequences/viruses being worked with in the Wuhan lab must have been in the public domain.
Sometimes, they invoke a bizarre generalization that virologists are gossipy and can't keep novel viruses to themselves.
They already surmised in early 2020 that a lab performing gain of function, eg cleavage site insertion, would NOT use an existing close relative of SARS or MERS.
This private speculation by Western virologists later matched up with the wording in a research proposal submitted by the EcoHealth Alliance, other US collaborators, and the Wuhan Institute of Virology. documentcloud.org/documents/2106…
To translate the science-speak in the March 2018 Defuse proposal, the scientists said that they were on the look out for cleavage sites in novel SARS-like viruses, which they could then optimize and insert into less risky SARS-like viruses in their possession.
The fact remains that the virus database at the Wuhan Institute of Virology remains inaccessible after being taken offline in late 2019.
Even its collaborators have not been able to produce a copy of the viruses/sequences found by the Wuhan scientists.
The fact remains that the 100s of SARS-like virus sequences discovered by the Wuhan scientists are not fully accounted for in the public domain.
I cannot find the sequences for WIV's 220 SARS-CoV-1-like viruses (2022 interview) or 180 unique SARS-like viruses (2018 proposal).
From their FOI'ed emails, it seems these experts understand that we don't know what was happening in Wuhan labs and what viruses they were experimenting with.
Yet, they keep telling journalists and people in gov that they know a precursor to SARS2 did not exist in Wuhan labs.
I don't think this behavior means they know the #OriginOfCovid (or even that they still privately think a lab origin likelier than not), but imo it looks like a desperation to persuade the public that there's some kind of scientific certainty on the natural origin of the virus.
Some of these experts caveat their certainty of natural #OriginOfCovid by saying if direct evidence of a lab origin appears, they will change their minds.
I don't care if you change your mind later. What would be appreciated from you is a scientific approach to this issue today.
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"SARS-CoV-2 is, to date, the only identified member of the subgenus sarbecovirus that contains an FCS, although these are present in other coronaviruses"
@PeterHotez@pnas "We do know that the insertion of such FCS sequences into SARS-like viruses was a specific goal of work proposed by the EHA-WIV-UNC partnership within a 2018 grant proposal (“DEFUSE”)"
@PeterHotez@pnas "We do not assert that laboratory manipulation was involved in the emergence of SARS-CoV-2, although it is apparent that it could have been. However, we do assert that there has been no independent and transparent scientific scrutiny to date..."
"EHA-WIV-UNC was involved in the collection of a large number of so-far undocumented SARS-like viruses.. manipulation within.. (BSL)-2.. raising concerns that an airborne virus might have infected a.. worker" pnas.org/doi/10.1073/pn…
@TheLancet There are 2 components to the Harrison & Sachs letter.
1. There are parties in the US that have repeatedly resisted sharing information relevant to #OriginOfCovid and they should be compelled to cooperate in a formal, ideally bipartisan, US-based investigation.
Some scientists are a bit confused. Just because *globally* there are more than 180 SARSrCoV sequences published, doesn't mean that the 180+ SARSrCoV sequences from the Wuhan/EcoHealth scientists have all been accounted for.
Unless you mean to say that when the EcoHealth and Wuhan scientists wrote a research proposal with the line ">180 bat SARSr-CoV strains sequenced in our prior work and not yet examined for spillover potential", they actually meant the global research community's "prior work".
If the above is true, I would say that that's a very sly way of claiming credit for work you didn't do to get more funding.
I don't think the EcoHealth/Wuhan scientists would claim all known SARSrCoV sequences globally as part of their prior work.
Looking forward to the case study on #OriginOfCovid - how a small group of scientists managed to create a mass illusion of scientific consensus via groupthink and connections with prominent science journalists/writers.
I'm not sure that #SciComm folks could've predicted that some of the worst misinformation during the pandemic would've come from experts instead of mis/disinformants.
If you're a scientist or journalist promoting the benefits of virus hunting (in natural habitats, wildlife trade etc.) and manipulation in laboratories around the world, please practice some circumspection.
Millions might've died from precisely this type of research gone wrong.
A lab-based outbreak doesn't require any fancy bioweaponry or shenanigans (e.g. serial passaging to select for cross-species airborne transmissibility) in the lab.
It can be as simple as scientists chancing on a dangerous natural pathogen in the wild and bringing it into cities.
Top experts in virology and infectious diseases understand this. They know that viruses that have spent time in laboratories don't necessarily have to look different from what we see in nature.
If the @USRightToKnow and others keep suing for virologist emails via the freedom of information act, we might finally get to see their honest reactions to the Defuse proposal or perhaps their transition to non-FOI’able channels of communication.
This 2020 email doesn’t make me feel particularly confident in the current membership of the NSABB advising federal policies on potential pandemic pathogen research.
Emails such as this make me wonder about science journalism. AFAIK this @nytimes journalist concerned about the risks of pathogen research did not eventually publish an article on #OriginOfCovid
Instead @nytimes kept publishing articles about how unfounded lab origin was.