Hannah Davis Profile picture
May 18, 2022 8 tweets 4 min read Read on X
Big #LongCovid paper out with a lot of new insights (n=78k)!

-76% of LC patients were not hospitalized (!!)
-82% of female patients non-hospitalized vs 68% males
-36-50 year olds were the highest risk age group
-59.8% of patients female; 46.2% male

s3.amazonaws.com/media2.fairhea…

1/
-31% had no pre-existing condition

-Heartbeat irregularities were more common in age 13-22 (possibly dysautonomia)

-Myopathies (diseases that affect the muscles that control voluntary movement) were 11.1x more common in #LongCovid compared to the same population pre-COVID!

2/
On average, patients with #LongCovid had higher
HHS-HCC risk scores after COVID-19 than before.

HHS-HCC risk scores identify which patients are likely to consume more healthcare resources & incur more healthcare-related costs in the long run.

3/
Of everyone diagnosed with a #LongCovid code, the most common age range was 36-50.

4/
As other studies have found, there is a gender difference, but it heavily depends on age group! For children under 12 and adults over 50, the chance of getting #LongCovid is almost equal between male and female patients.

5/
Obstructive sleep apnea was the most common sleeping diagnosis, which seems weird to me. Wonder if any of these are actually central apnea?

6/
A few diagnoses were highlighted as uncommon but potentially serious, with a large difference between pre- & post-COVID.

These included myopathies (11.1x more common), diseases affecting the interstitium (4.8x more), pulmonary embolism (2.6x), other brain disorders (2x).

7/
Breakdown of "other disorders of the brain", which seems to be ME/CFS-type manifestations, metabolic encephalopathy, and encephalopathy.

8/

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More from @ahandvanish

Oct 12, 2024
Incredible visit Thursday to the opening of Mount Sinai’s Cohen Center for Recovery from Complex Chronic Illness, led by the renowned @PutrinoLab! #LongCovid 1/ Sign that says Cohen Center for Recovery from Complex Chronic illness
David Putrino in the center, masked, showing off tools used for metabolic and mitochondrial dysfunction
The Center is incredible and truly blew me away - designed on so many levels with patients in mind, with top notch care, using many of the most advanced tools available 2/
Some of the many tools patients are assessed with include:

-EndoPat (endothelial dysfunction)
-tilt table (dysautonomia)
-transcranial Doppler (cerebral blood flow)
-machine that identifies metabolic & mitochondrial dysfunction
-eeg & cognitive battery

3/
Read 8 tweets
Aug 28, 2024
Major paper! The team found that fibrinogen (which converts to fibrin):

-binds to spike
-forms clots + neuro issues
-acute stage fibrinogen = predictive biomarker of #LongCovid cog dysfunction!
-suppresses natural killer (NK) cells (which clear virus!)
1/nature.com/articles/s4158…
The fibrin also:
-promotes neuroinflammation & neuronal loss post infection
-promotes innate immune activation in the brain & lungs independent of active infection
-downregulated JAK-STAT pathway & targets of p38 MAP kinase, pathways that regulate NK cell activation #LongCovid 2/
They used a monoclonal antibody targeting the fibrin domain, and found it protected against microglial activation & neuronal injury, as well as from thromboinflammation in the lung after infection! #LongCovid 3/
Read 5 tweets
Jul 11, 2024
I've been doing #TheNicotineTest (via 7mg patches) for a month now & it has greatly improved my quality of life.

Major caveat: I'm on ivabradine. The nicotine increases heart rate, & I wouldn't recommend to anyone w POTS who isn't on beta-blockers or ivabradine. #LongCovid 1/
The biggest change is feeling like I have more *oxygen* circulating in my body - the weird altitude-sickness feeling is lessened.

Major improvements to cognition/awareness (esp executive functioning & processing), and improved physical capacity and overall baseline. 2/
The first tolerance break I felt more air hunger and worse baseline than pre-nicotine, but every other tolerance break has been equal or better than pre-nicotine.

It feels like an excellent symptom management tool, but *not* a cure. 3/
Read 7 tweets
May 1, 2024
From the Conference of Retroviruses & Opportunistic Infections: persistence of Covid in megakaryocytes in #LongCovid.

Over my head, but my understanding: megakaryocytes (type of bone marrow cell) being infected = continuous infection, very serious!

1/ croiconference.org/wp-content/upl…
graph showing levels of circulating Megakaryocytes; very low for healthy controls, high for severe Covid and Long Covid
This could cause additional impacts like deficits in platelet energy metabolism, or hormonal dysregulation (because platelets carry serotonin) #LongCovid

More about this here from the amazing @polybioRF!

2/polybio.org/projects/sars-…
The study found:

-circulating megakaryocytes harbored Spike, SARS-CoV-2 ssRNA, & dsRNA in #LongCovid patients

-these produced platelets containing Spike & SARS-CoV-2 ssRNA 3/
Read 5 tweets
Oct 30, 2023
Because this video has caused so much willful misinterpretation, I want to clarify: in the clip I’m countering the myth that #longcovid is lingering symptoms of acute COVID, since many people think it’s just a cough. I should‘ve said “acute COVID”; brain fogged & trying my best.
The interview was an hour long & they edited it to 5 min. I talked their ear off about all hypotheses & the science behind each & it didn’t make it in - the piece was for a general audience. I talked about all the other things COVID can cause, include diabetes & clots, at length.
Anyone who is suggesting I don’t think #longcovid is from COVID (????) or that I don’t think viral persistence is a high priority hypothesis (????) are *actively* ignoring 3.5 yrs of advocacy & that I’ve been highlighting viral persistence since 2020
Read 7 tweets
Sep 20, 2023
The most exciting hypotheses in #LongCovid and #pwME are ones that could have cures! This includes viral persistence and others, and also includes the itaconate shunt hypothesis. I'm going to tweet this video as I watch it to try to explain it more 1/
Dr. Ron Davis used to work on the Human Genome Project but switched to ME/CFS when his son got sick. He's the director at the Stanford Genome Center. He is focused on *a cure* for ME/CFS. "I believe it is a curable disease." 2/ slide that says "ME/CFS - A curable disease?"
He describes the common onsets of ME - usually viral, but can have other causes too, refers to a big parasite onset in Norway from a few years ago 3/ Image
Read 13 tweets

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