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Portugal has furthered the sequencing of the monkeypox virus causing the current outbreak—50 divergences 'far more than one would expect' say Portuguese scientists: 'hypermutated virus' cannot be 'discarded'
Portugal has furthered the sequencing of the monkeypox virus causing the current outbreak—50 divergences 'far more than one would expect' say Portuguese scientists: 'hypermutated virus' cannot be 'discarded'
2/
The report says that there are 50 SNPs (single nucleotide polymorphisms): 50 changes in the genetics of the virus from the last isolated samples in Europe in 2018-2019.
'The outbreak virus diverges a mean of 50 SNPs from those 2018-2019 viruses (46 SNPs from the...
The report says that there are 50 SNPs (single nucleotide polymorphisms): 50 changes in the genetics of the virus from the last isolated samples in Europe in 2018-2019.
'The outbreak virus diverges a mean of 50 SNPs from those 2018-2019 viruses (46 SNPs from the...
3/
...closest reference—which is far more than one would expect considering the estimated substitution rate for Orthopoxviruses '
The report says.
Indeed these are massive deviations in the genetics of the virus.
...closest reference—which is far more than one would expect considering the estimated substitution rate for Orthopoxviruses '
The report says.
Indeed these are massive deviations in the genetics of the virus.
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'one cannot discard the hypothesis that the divergent branch results from an evolutionary jump (leading to a hypermutated virus) caused by APOBEC3 editing'
They add.
'one cannot discard the hypothesis that the divergent branch results from an evolutionary jump (leading to a hypermutated virus) caused by APOBEC3 editing'
They add.
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APOBEC3G :
'is a human enzyme encoded by the APOBEC3G gene that belongs to the APOBEC superfamily of proteins. '
en.wikipedia.org/wiki/APOBEC3G
And plays an important role in the innate & adaptive immune system for responding to infection by retroviruses such as HIV and...
APOBEC3G :
'is a human enzyme encoded by the APOBEC3G gene that belongs to the APOBEC superfamily of proteins. '
en.wikipedia.org/wiki/APOBEC3G
And plays an important role in the innate & adaptive immune system for responding to infection by retroviruses such as HIV and...
6/
...It is believed to also play an important role in immunity for 'parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus and retrotransposons'
ncbi.nlm.nih.gov/pmc/articles/P…
...It is believed to also play an important role in immunity for 'parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus and retrotransposons'
ncbi.nlm.nih.gov/pmc/articles/P…
7/
Meaning that the virus may have new abilities to alter immune response: potentially picking this up from some sort of significant evolutionary jump.
ncbi.nlm.nih.gov/pmc/articles/P…
Meaning that the virus may have new abilities to alter immune response: potentially picking this up from some sort of significant evolutionary jump.
ncbi.nlm.nih.gov/pmc/articles/P…
8/
They have observed a series of 'microevolutions' already occurring during the current outbreak leading to 7 SNPs with 3 different branches:
These gene loss events have previously been associated with increased human spread of the virus:
They have observed a series of 'microevolutions' already occurring during the current outbreak leading to 7 SNPs with 3 different branches:
These gene loss events have previously been associated with increased human spread of the virus:
9/
Correlating with a potential finessing effect as the virus drops needless material to infect and replicate more and more.
Correlating with a potential finessing effect as the virus drops needless material to infect and replicate more and more.
10/
The research supports the hypothesis that this is a new variant and it appears to be getting better at spreading the more it spreads.
The research supports the hypothesis that this is a new variant and it appears to be getting better at spreading the more it spreads.
Source:
virological.org/t/multi-countr…
virological.org/t/multi-countr…
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