Thread by @ERheumat

#EULAR2022
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
👁‍🗨 Awesome class on IIM pathogenesis
👁‍🗨The MSA and Phenotype Slide is 👌🏻👌🏻

#EULAR2022
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
👁‍🗨Summary of Mechanisms
👁‍🗨DM/JDM👉🏻 CD4 and TH17 mediated
👁‍🗨 Both Inflammatory and non inflammatory factors contribute

#EULAR2022
👁‍🗨 Type I,II IFN sig
👉🏻 DM/JDM>>ASS/PM>IBM>IMNM
👉🏻 Mi2/TIF/MDA5>>Jo1>>SRP/HMCGR
👁‍🗨⬆️INF levels 👉🏻⬆️ disease activity
👁‍🗨pDC and mDC mediated
👁‍🗨Mediate Muscle atrophy(perifasicular) and Capillary loss

#EULAR2022
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
👁‍🗨NETs & LDG⬆️ in Blood, Muscle, Lung & Skin
👁‍🗨MDA5 ⬆️NETs>>MJ,TIF,Jo1

#EULAR2022

👁‍🗨 Vasculopathy JDM>>>DM
👁‍🗨 Muscle damage in IIM us Multifactorial
👁‍🗨 DM 👉🏻 ⬆️INF, TNF, NF-KB
👁‍🗨IMNM👉🏻 ⬆️APR and ⬇️ Lymphocyte response
👁‍🗨ASS👉🏻 ⬆️APR, RNA binding ⬇️Muscle func, ubiquitination

#EULAR2022
👁‍🗨 Calcinosis JDM>>DM
👁‍🗨 CD3+ T Cells and Macrophages have a role
👁‍🗨 NETs engulf Ca crystals and Ca crystals cause NETOSIS
👁‍🗨Mitochondrial calcification
👁‍🗨 ⬆️ SIBLING protein expression

#EULAR2022
Contrasts in pathomechanisms and treatment targets between adult and paediatric inflammatory myositis
Summary Slides