#EULAR2022
IBD management for Rheumatologist
🔎The options have been increasing over the years
🔎Remission rates have still not crossed 30-40% Ballpark
#EULAR2022
IBD management for Rheumatologist
🔎Target of therapy is
♦️Clinical remission in short term
♦️Histological remission in medium-term
♦️Disease Modification in Long
🔎Histological activity better marker of future Flare
#EULAR2022
IBD management for Rheumatologist
🔎Very Few Head to head trial to decide biologic of choice
🔎 Vedoli>Adali but Ustki=Adali
#EULAR2022
IBD management for Rheumatologist
🔎Combination of Biologics or Biologics + DMARDS is way to go for ⬆️ remission rates
🔎 Guselkumab+Golimumab works 👉🏻 intresting 🤔
🔎Ifliximab+AZA also good
#EULAR2022
IBD management for Rheumatologist
🔎diet might help in controlling disease
#EULAR2022
IBD management for Rheumatologist
🔎Fibrosis an issue
🔎Post-op flare rates still high (upto 70%)
🔎Creeping fat specific for IBD and might start earlier than thought, might be pathological
#EULAR2022
IBD management for Rheumatologist
Conclusions
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🧵 1/9 Key insights on AAV treatment from #ACR24. Dr. Langford's session highlighted the latest guidelines and therapeutic strategies. Let's dive in! #Vasculitis #Rheumatology
🎯 2/9 AAV Treatment Goals: Remission, relapse prevention, minimize toxicity, organ damage, and optimize patient quality of life. Keep these in mind when choosing therapies. #AAV #TreatmentGoals
📚 3/9 Guidelines: ACR/VF (2021), KDIGO (2024), EULAR (2022), PANLAR (2023) - all provide crucial recommendations. Familiarize yourself with these! #AAVGuidelines #EvidenceBasedMedicine
(1/10) #ACR24 Key Sarcoidosis Takeaways for Rheumatologists:
Sarcoidosis diagnosis relies on clinical probability, not "proof."
Patient-reported outcomes (ROS) are crucial for understanding disease extent & activity, guiding us to occult disease.
Diagnostics have limitations!
(2/10) #ACR24 Sarcoidosis epidemiology is complex.
Prevalence & incidence vary globally, with higher rates in Black individuals & females.
While ~80% achieve resolution in 2 years, disparities in diagnosis & treatment lead to poorer outcomes.
More research is needed!
(3/10) #ACR24 Sarcoidosis etiology remains unknown.
Environmental, occupational, & infectious agents are suspected triggers.
Genetic predisposition plays a role.
Remember to consider medication reactions (TNFi's, ARVs, CTx) in the differential diagnosis.
#ACR22#ACR2022
12S129. Purple Peripheries: Vasculopathy VS Vasculitis
Philip Seo is awesome as always
The most common cause is Cardiovascular followed by Rheumatic
More commonly vasculopathy than Vasculitis
#ACR22#ACR2022
12S129. Purple Peripheries: Vasculopathy VS Vasculitis
Algorithm for Digital ischemia in Rheum
Mx for Gangrene in SSc
#ACR22#ACR2022
12S129. Purple Peripheries: Vasculopathy VS Vasculitis
Large and Small vessel rarely cause Digital gangrene
#ACR2022#ACR22
12S130. Rheumatology Secrets and Pearls
Dr John Stone, at his best
🎯RA may present with asymmetric arthritis
🎯AAV might present with migratory oligoarthritis, which is steroid responsive
🎯Only a quarter of RA patients go into remission during pregnancy
#ACR2022#ACR22
12S130. Rheumatology Secrets and Pearls
🎯Following trends is more important in pregnancy that stat values (ESR/Complements)
🎯Proteinuria⬆️ creat ⬇️ due to ⬆️ GFR and maternal Blood volume in pregnancy
#ACR2022#ACR22
12S130. Rheumatology Secrets and Pearls
🎯Puffy fingers may be the first sign of SSc in RNApolIII SSc and No Raynaud's - May present with SRC
🎯ACEi are best kept reserved for SRC
#ACR2022#ACR22
12S130. Rheumatology Secrets and Pearls
Jason Kolfenbach, with his wonderful pearls 1. Vasculitis Pearls
🦪For Steroids ➡️ Less is more
🦪Be very careful in stopping Rx in AAV pts
🦪Don't give up on PLEX in suspected AAV Anti-GBM may have ANCA positivity.
#ACR2022#ACR22
12S130. Rheumatology Secrets and Pearls
🦪Not all Skin thickening = SSc
🦪Lipodermatosclerosis (with inverse 🍾 sign)
🦪Thyroid disease important mimics
🦪PPI can cause diarrhoea
🦪FVC/DLCO ratio can help diagnose ILD/PAH
#ACR2022#ACR22
12S130. Rheumatology Secrets and Pearls
🦪30% SLE pts have APS
🦪DLE uncommonly progresses to SLE
🦪PPIs, NSAIDs, Anti-HTN meds commonly cause SCLE