Thread by @ERheumat

#EULAR2022
Rheumatology across boundaries
The eye in rheumatic diseases
🧿The Pathophysiology of Uveitis is poorly understood
🧿 Uveitis is thought to be due to enthesitis of ciliary body attachment
🧿TH17 and TH1 are major mediators of inflammation

#EULAR2022
Rheumatology across boundaries
The eye in rheumatic diseases
🧿 Most common extra-articular feature
🧿 HLA-B27+vity, Recurrent uveitis and IBP 🚩 for rheumatology referral

#EULAR2022
Rheumatology across boundaries
The eye in rheumatic diseases
🧿 Non-Anterior non infectious Uveitis has a no of causes 👉🏻 makes studying the disease difficult
🧿 Sarcoid, Behcet's other imp causes
🧿 Topical Rx 1st for Anterior Uveitis
🧿 Systemic 1st for NIU

#EULAR2022
Rheumatology across boundaries
The eye in rheumatic diseases
🧿 Multiple Rx available 👉🏻 No head to head Trial
🧿 MMF=AZR=MTX
🧿 early DMARDS and early Biologics in the algorithm may prevent GC ADRs

#EULAR2022
Rheumatology across boundaries
The eye in rheumatic diseases
🧿Treatment Challenging due to lack of good RCTs
🧿 Multiple Unmet needs
🧿 Patient and Non-patient factors decide Rx

#EULAR2022
Rheumatology across boundaries
The eye in rheumatic diseases
🧿Adalimumab effective in JIA-Uveitis
🧿 Tocilizumab has been shown to be effective in resistant cases