Share this page!

Maybe Scrolly?
Wong yujun Profile picture
Twitter logo
Jun 22 • 5 tweets • 7 min read
🔥Liver support system by Dr Faouzi Saliba

🌉to transplant

Plasma exchange
✅Transplant-free survival
✅Ongoing RCT (APACHE trial)

⛔️Not for those beyond #ACLF-3

#ILC2022 #Livertwitter @EASLnews @EASLedu Image
Plasma exchange in:
✅ HBV-ACLF
✅ ALF

#ACLF #ILC2022 @EASLedu ImageImage
🔥Hepatocyte transplant by Dr Anil Dhawan

✅Human hepatocytes
✅Children with ALF (n=8)
👉Alginate microencapsulated, peritoneal transplantation

Read more:👉doi.org/10.1016/j.jhep…

#ILC2022 #Livertwitter @EASLnews @EASLedu @Apichatka @jturnesv @aelsharkawy75 @LiverNotFighter Image
🔥Liver stem cells by Dr Fotios Sampaziotis

🤩Amazing advances field of liver/biliary cell

Biliary repair:
- Limited tx option
- Retrograde injection of biliary stem cells👇

#ILC2022 @EASLnews ImageImageImage
Liver renegeration by Dr Pierre Clavien

- Increase portal vein inflow
- 2-stage hepatectomies
- metabolic stimulation (regeneration-associated steatosis)
- Integrated perfusion machine
👉10.1038/s41587-019-0374-x

#ILC2022 @aelsharkawy75 @EASLnews ImageImageImage

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Wong yujun

Wong yujun Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @wong_yujun

Wong yujun Profile picture
Jun 24
#ILC2022 @EASLedu @EASLnews @ebtapper @BloomPringle @Apichatka @markakismd @MartaBAfonso @LouisHSLau @jlouissaint89 @ajay_duseja @salvatore_piano
🔥#ACLF-3: early vs late transplant @JosephAlukal

👉UNOS database: n=3,498
✅Better 90-day and 1-year survival for early LTx (<7 days)
🤔 Selection bias who goes for early vs late LTx?

#ILC2022 #Livertwitter @EASLedu @EASLnews
@VinaySundaramMD @RajivJalan1 @DrLiver @ebtapper Image
🔥Urine NGAL predicts response to Terlipressin/albumin in HRS by Dr Carmine Gambino

N=162 #cirrhosis, 🇮🇹
AKI>48hrs
urine NGAL:
⏫ ATN-AKI
⬇️ in Terli responders
💡NGAL>220 predict 90-day Mortality (AUROC: 0.85)

#ILC2022 #Livertwitter @salvatore_piano @ProfPaoloAngeli Image
Read 7 tweets
Wong yujun Profile picture
Jun 23
🌎Global CLEARED registry by @JasmohanBajaj

n=1,383; Reason for admission: GI bleeding🩸, HE🧠
✅Infection🦠: 25%
✅AKI: 46%
✅30-D Readmission: 33%
🪦30-D Mortality: 33%
😟Transplant: 11%

#ILC2022 #LiverTwitter @EASLedu Image
Recruitment/selection policy on post-LTx in ACLF-3 by Dr Thierry 🇫🇷

🪦3-year survival: ACLF-3 ⬇️ 66% vs 82%
✅Volume ⏫, survival ⏫
✅Survival gap diminished btw #ACLF-3 vs non-AC LF 3👍

How?

💡MDT, post-ICU care, TAM score, surgery/anes
✅ICU network (list from ICU)
#ILC2022 Image
⛔️When not to transplant #ACLF-3?

Combination of:
💡Age, Lactate, MDR infection, Respiratory

Give⏲️

#ILC2022 #Livertwitter
Read 5 tweets
Wong yujun Profile picture
Jun 23
📢Personalized medicine in #NAFLD by @DrLoomba

✅Current gaps in #NAFLD:
- Rapid progressors
- non-cirrhotic HCC

😧At risk NASH (F2 beyond)? Try these👇
✅FAST (low PPV) - exclude biopsy
✅MAST (PPV 91-97) - rule-in & treat
✅MEFIB (AUROC 0.9)

#ILC2022 #Livertwitter @EASLedu Image
Personalized medicine in #NAFLD by @DrLoomba

🔥Gut microbiome (AUROC 0.936)
- Detect advanced #fibrosis
- Identify 1st-degree relative with #cirrhosis (ethnically universal)
👉DOI: 10.1016/j.cmet.2020.06.005

- FGF19 treatment response in #NASH

#ILC2022 #LiverTwitter @EASLedu Image
Personalized #NASH treatment by @DrLoomba

Choose yr drugs based on🎯
⏩#Fibrosis reversal vs #NASH resolution?

✅Combination = way forward. Why?
⏫Efficacy
⏬Dose ( ?potentially ⏬AE)

#ILC2022 #LiverTwitter @jturnesv @aelsharkawy75 @IanARowe @DharJahnvi @drshafikuchay ImageImageImage
Read 4 tweets
Wong yujun Profile picture
Jun 22
Improving MELD by @elizebeth_verna

🤔Why changes are needed MELD allocation? 👇

1) Changing epidemiology of cirrhosis (⏬HCV, ⏫Alcohol/NASH)
2) Creatinine - under-estimate kidney injury esp female
3) 🔼Female wait-list mortality

#ILC2022 #Livertwitter @EASLedu
Evolution of MELD

🤔What's new in MELD 3.0?
- Gender, albumin, bilirubin

✅Advantages:
- ⏬Gender-based disparity (sex & height)
- ⏬Creatinine cap
- 👍Adjust for Interaction bil-NA & creatinine-albumin

#ILC2022 #Livertwitter @elizabeth_verna @EASLedu
🔥Beyond MELD:

✅ Better predict kidney injury (nGAL) & reversibility
✅ Clinical predictor: ACLF, frailty (LFI) ?sarcopenia
✅ AI (data source? biological plausibility?)
✅ Focus on transplant benefit score > wait-list mortality

#ILC2022 #Livertwitter @elizebeth_verna
Read 4 tweets
Wong yujun Profile picture
Jun 22
🔥BIomarkers by Dr @RautouE

1) Novel biomarkers:
CT scan:
- Liver surface nodularity predicts decompensation & survival
- SPSS predict HE (MELD<10)

#ILC2022 #Livertwitter @EASLnews

1/5 ImageImage
ImageImageImage
Novel biomarkers:
2) Extracellular vesicles
- released when stress
- predict decompensation (60% at 2-yr )

#LiverTwitter @RautouE #ILC2022

2/5 Image
Read 7 tweets
Wong yujun Profile picture
Jun 22
Endohepatology by Dr Wim Laleman

Potential roles of EUS:
✅Liver biopsy - potential advantages
✅GV treatment - coil +/- glue
✅Intrahepatic portosystemic shunt
✅Portal-pressure measurement

#LiverTwitter #ILC2022 @EASLnews @AASLDtweets @APASLnews
@EASLnews @AASLDtweets @APASLnews Benefits of EUS-guided liver biopsy & EUS guided GV treatment

#ILC2022 ImageImage
🔥🔥HVPG vs EUS-PPG? Which camp are you in?

🤔Sedation effect on PPG measurement?
👉Correlation btw HVPG vs PPG? Long-term data?
-> await Encounter trial

#ILC2022 @ASGEendoscopy @helpatologist @ggarciatsao @LizzieAbyMD @jaumebosch9 Image
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(