Discover and read the best of Twitter Threads about #NASH

Most recents (8)

What can patients with #NASH expect from clinical trials?

Recent negative results from $GILD and now $GNFT in Phase 3 highlight the uncertainties entering trials that patients face

Is there a minimum potential benefit a patient should accept when entering a trial?

THREAD
In Phase 3, participants with #NASH entering a trial there is no certainty that the drug being tested will work and they are taking a risk with a new treatment

Is there a minimum threshold for benefit in a trial that participants might expect?

2/n
Earlier today, I asked #livertwitter what the minimally important difference would be for histologic improvement in phase 3 trials in NASH

The majority thought that at least a 25% absolute improvement in either NASH or fibrosis was the minimum



3/n
Read 16 tweets
On enchaine sur un LT Partage d’expérience dans la prise en charge des patients malades du foie en situation de pandémie avec Marc Bourlière (Marseille), Jean-Pierre Bronowicki (Nancy),
Nathalie Ganne-Carrié (Paris), Georges-Philippe Pageaux (Montpellier) webconfaei.com/hepatonews-cov…
La conférence commence par un tour de table concernant l'organisation des soins en milieu hospitalier puis par une présentation de la maladie #COVIDー19
Jean-Pierre Bronowicki (Nancy) : on va partir de vignettes cliniques. La 1ère est celle d'un patient usager de drogue, ayant une consommation excessive d'alcool mais prêt à débuter les #AAD antiviraux directs.
Read 27 tweets
@AGA_Gastro highlights #NASH #NAFLD first up @VidalPuig Where do the fatty acids go? sciencedirect.com/science/articl…
#NAFLD #NASH How much does the clock matter for pathophysiology or therapeutics #circadian sciencedirect.com/science/articl…
“Lost in Translation” or Utility at Last? NASH biomarkers #genetics and risk prediction beyond PNPLA3 sciencedirect.com/science/articl…
Read 6 tweets
1). Made list of most interesting private co's at #JPM20

Always insight to be gleaned on how these co's will trade post-IPO

Helpful to learn stories BEFORE S-1's hit

Requesting that BioTwitter attendees record audio & share. (Phone got vid of $MDXG breakout in '18)

$XBI $IBB
2). Here's the source of the private companies attending #JPM20

There will likely be more added over time. Assuming that the most important ones were booked first

Will annotate companies by indication/modality below
3). Tools, MDx & "Organism Eng. Platform" co's at #JPM20

@GenapSys | $ILMN $PACB @nanopore competitor | Investor: @ForesiteCapital

@berkeley_lights | single-cell manipulation & microfluidics combo for antibody discovery & cell line dev, used by @Ginkgo | Investor: @sequoia
Read 29 tweets
1/4: GRAPH OF THE WEEK! Abnormal liver function, fatty liver #NAFLD #NASH now affects 20% of the developed world BUT WHY? For years I thought it was drugs or alcohol, so did the Three gastroenterologists who saw this lady between 1996 and 2009 Look rapid improvement on low carb
2/4 Who knew but we make liver fat not from dietary fats but sugar and starchy carbs Its called De novo lipogenesis. Guess what insulin and glucose is involved, look doi.org/10.1172/JCI134… The liver fat produced is called triglyceride and is more important than I used to think
3/4 So its like insulin pushes blood glucose into liver cells which turn it into triglyceride. Over time the liver fills with this fat hence #fattyliver #NAFLD also inflammation may set in #NASH My free @rcgp podcast is here only 18 mins @MartinRCGP elearning.rcgp.org.uk/mod/page/view.…
Read 4 tweets
1/13
Primer ensayo clínico fase 3 con resultados positivos en pacientes con esteatohepatitis no alcohólica (#NASH) ow.ly/28oF50xuGPY en @TheLancet. El ácido #obeticólico reduce el grado de fibrosis hepática en pacientes con NASH y fibrosis avanzada. ¿Es lo que esperábamos?
@TheLancet 2/
Para empezar ¿qué esperas de un tratamiento para la esteatohepatitis no alcohólica?
@TheLancet 3/
Hay que valorar los resultados con cautela, se trata de un análisis interino a los 18 meses de tratamiento en pacientes con #NASH y fibrosis F2-F3. Incluye "solo" 931 pacientes con 2 biopsias de los 1968 aleatorizados. Los objetivos coprimarios son histológicos, y no clínicos
Read 13 tweets
Imagina por un momento (sólo un ratito, lo prometo) que eres un ladrón. Un “amigo” y tú, ocultos tras unas inquietantes máscaras de Dalí, habéis atracado un banco y habéis conseguido un apetitoso botín que ya está a buen recaudo. Todo bajo control.
Sin embargo, un oficial de policía que os andaba pisando los talones desde hacía tiempo aparece por sorpresa y os detiene. Maldita sea. Suerte que nadie podrá acusaros de haber cometido el delito si el botín no aparece…
Os ha llevado a comisaría, os ha separado en celdas independientes y estáis completamente incomunicados. Un par de horas después, el policía reaparece en tu celda para proponerte algo que te deja loco, muy loco.
Read 18 tweets
[1] "After serving as a partner at the Boston law firm of Hill and Barlow, #RobertMueller [] in 1989, he served in the US Department of Justice as an assistant to Attorney General Dick #Thornburgh and as acting Deputy Attorney General." See #Wikipedia
[2] What was AG Dick #Thornburgh responsible for 1989 ?

"Criminal Investigation Is Begun at Arms Plant" -
By DAVID JOHNSTON and SPECIAL TO THE NEW YORK TIMES - JUNE 7, 1989

That plant was #RockyFlats in Colorado
[3]
* Bush 41 appointed AG Dick Thornburgh (1989)
* Mueller joins DOJ as assistant to Thornburgh (1989)
* FBI Raids Rocky Flats - Largest criminal investigation of nuclear environmental damage in US history
* Rocky Flats 5 under #LPGise (grandad of Jeff Bezos) until 1965
Read 19 tweets

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