Improving MELD by @elizebeth_verna
🤔Why changes are needed MELD allocation? 👇
1) Changing epidemiology of cirrhosis (⏬HCV, ⏫Alcohol/NASH)
2) Creatinine - under-estimate kidney injury esp female
3) 🔼Female wait-list mortality
#ILC2022 #Livertwitter @EASLedu
🤔Why changes are needed MELD allocation? 👇
1) Changing epidemiology of cirrhosis (⏬HCV, ⏫Alcohol/NASH)
2) Creatinine - under-estimate kidney injury esp female
3) 🔼Female wait-list mortality
#ILC2022 #Livertwitter @EASLedu
Evolution of MELD
🤔What's new in MELD 3.0?
- Gender, albumin, bilirubin
✅Advantages:
- ⏬Gender-based disparity (sex & height)
- ⏬Creatinine cap
- 👍Adjust for Interaction bil-NA & creatinine-albumin
#ILC2022 #Livertwitter @elizabeth_verna @EASLedu
🤔What's new in MELD 3.0?
- Gender, albumin, bilirubin
✅Advantages:
- ⏬Gender-based disparity (sex & height)
- ⏬Creatinine cap
- 👍Adjust for Interaction bil-NA & creatinine-albumin
#ILC2022 #Livertwitter @elizabeth_verna @EASLedu
🔥Beyond MELD:
✅ Better predict kidney injury (nGAL) & reversibility
✅ Clinical predictor: ACLF, frailty (LFI) ?sarcopenia
✅ AI (data source? biological plausibility?)
✅ Focus on transplant benefit score > wait-list mortality
#ILC2022 #Livertwitter @elizebeth_verna
✅ Better predict kidney injury (nGAL) & reversibility
✅ Clinical predictor: ACLF, frailty (LFI) ?sarcopenia
✅ AI (data source? biological plausibility?)
✅ Focus on transplant benefit score > wait-list mortality
#ILC2022 #Livertwitter @elizebeth_verna
Summary of the insightful talk by @elizabeth_verna 👏
#ILC2022 #Livertwitter @EASLedu @AASLDtweets @APASLnews
#ILC2022 #Livertwitter @EASLedu @AASLDtweets @APASLnews
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