Elliot Tapper Profile picture
Jul 11 5 tweets 2 min read
The best way to ensure best outcomes for your patient with variceal bleeding is to treat it

Sadly: 1 in 7 bleeds receives no endoscopic therapy

Why? 🧵

#livertwitter
The top reasons I have seen are:

🚫But the varices weren’t bleeding at the time
✅varices bleeding can be intermittent. #cirrhosis plus hemetemesis and varices at EGD = band

🚫I couldn’t visualize with all the 🩸
✅take time, reposition patient, use eryrhromycin
🚫not comfortable banding
✅phone a friend or transfer quickly

🚫cannot pass bander given patient anatomy
✅time for sclerotherapy (or glue)
Mortality due to variceal bleeding is high:
17.7% at 6 weeks
(Driven by Child Class)

The best way to give patients a shot:
1️⃣timely endoscopy with therapeutic intervention
2️⃣prophylactic antibiotics
3️⃣vasoactive drugs (terli or octreotide)

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More from @ebtapper

Jun 29
Why do portal vein thromboses happen?

🧵#livertwitter minireview of recent studies
This study showed that clots in the portal vein are associated with severity of portal hypertension

Not clotting factors or mutations
Not inflammation
In this study of whole livers removed at the time of transplant, we learned some portal veins have lots of intimal fibrosis.
You can’t anticoagulate that!

What is going on in these veins?!
Read 4 tweets
Jun 20
A patient with diabetes and recent NSTEMI treated with stent, clopidogrel, and atorvastatin ~2 months ago is transferred from OSH with ALT 1500, bilirubin 15

The leading diagnosis is statin liver injury

But that's not what it is.

Not at all
🧵
#livertwitter #liverstory
When she went to OSH, a bunch of tests were ordered

Blood tests (HCV ab, HAV, HBV surface antigen and core IgM, ANA, ASMA, IgG...) - all negative

Imaging (ultrasound, MRI) - nothing, no stones

OSH: It had to be the statin!

Narrator: But it wasn't
Statin induced liver injury is super rare. Consider it but dont close your mind to other possibilities.

If you want rates of injury, just ask @bjornsson_s who studied the Swedish national register in this @JHepatology paper. sciencedirect.com/science/articl…
Read 14 tweets
Jun 19
A patient with #cirrhosis and hepatic hydrothorax was admitted to an ICU 3 times for severe shortness of breath and hypoxia for urgent thoracentesis and diuretics

So we put in an indwelling catheter

Within weeks the output was minimal

What happened?

🧵
#livertwitter
This patient had ascites (weekly paras), hydrothorax, & high MELD including INR of 1.9, and plt 32.

She was small, weak. Sarcopenic.

Her creatinine 1.3.
Did you know that creatinine over-estimates renal function in women with #cirrhosis?

See MELD-Grail: aasldpubs.onlinelibrary.wiley.com/doi/abs/10.100… @AsraniSumeet
Read 11 tweets
Jun 12
Preparing a talk

Some tips🧵
1. Stay under time

Going over is bad. Dont

If you feel you have too much to say, cover less. Focus your talk more.

Strip out unnecessary examples or explanation. How? See point number 2👇
2. Stay under time through practice. Practice by recording yourself.

1⃣this times you
2⃣listen to yourself on commute, while exercising
3⃣think about what was missing, what needs to be cut or tightened
4⃣Edit
Repeat
(recent example below)
Read 8 tweets
Jan 7
some memories from liver clinic that make me happy when I think about them in this challenging year

#livertwitter
"I'm me again!"
- A text from a patient after I prescribed lactulose
My patient getting married in a ceremony officiated by the hospitalist when admitted
Read 12 tweets
Dec 9, 2021
1/
Tomorrow is the last meeting of the @AASLDtweets Practice Metrics Committee (PMC) chaired by @AsraniSumeet

He is the kindest, most committed collaborator and has done so much to shape and support the future of #cirrhosis quality

#livertwitter @serperm
2/
Sumeet was chair of this committee after Michael Volk and @KanwalFasiha. Under their leadership, we:

1. Defined the key PROs in #cirrhosis: pubmed.ncbi.nlm.nih.gov/29272043/
2. Developed quality metrics for #cirrhosis that included the patient voice: pubmed.ncbi.nlm.nih.gov/30586188/
and
3/
3. Developed quality metrics for liver cancer diagnosis and management: pubmed.ncbi.nlm.nih.gov/34778999/

Soon you will hear from the committee on PROs in liver cancer, metrics for liver transplant, and metrics for the management of #cirrhosis coagulopathy
Read 4 tweets

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