Thread by @humblesci

Our analysis of a novel SARS2r-CoV identified in game animal datasets in China shows the CoV to be related to GX #pangolin CoV and bat-SL-CoVZC45 in different sections of the partial genome researchsquare.com/article/rs-183…

We found the novel CoV phylogeneticly groups with GX PCoVs in the NSP4, NSP10 and a 297nt section of the RdRp coding regions. NSP4:

But the full RdRp groups with ZC45

And a partial 440nt section of the RdRp groups with multiple Zhoushan bat CoVs, indicating the CoV may be sourced from R.pusillus bats on Zhoushan Island

We find significal human genetic contamination of the animal datasets and identify the haplogroup to be of East Asian origin

And we identify multiple human hosted viruses including HPIV2 at 5% and 28% of reads in two animal datasets

Thanks to my awesome coauthors @stevenemassey @Daoyu15 @ydeigin and @quay_dr for putting in significant time and effort into this work

@robertson_lab @BatResearch would really appreciate if you have any feedback on the phylogenetic analysis and inferences