Just another ordinary day at #hemepathMDA … 🤯
60-70 y/o woman
To all brave #hemepath aficionados how would you classify this case?
Poll and individual high quality images below. Pls comment if you’re feeling particularly brave today, let’s talk new #WHO 😎 ImageImageImageImage
What’s your dx?
Better quality images ImageImageImage
High power IHC, the dual stain is PAX5/CD5, other one is LEF1 ImageImage
More smears ImageImageImage

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Keep Current with Sanam Loghavi, MD صنم لغوی 🔬🧬

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More from @sanamloghavi

Jan 8
The story of 1 day in the life of a #hematopathologist… I’m too exhausted to make a fancy educational thread but here are some amazing 🔬 pics for your viewing pleasure. I diagnosed all cases in one day 🤯 only at @MDAndersonNews Happy almost weekend people 🥂 #hemepath 🧵 1/n
Myeloproliferative neoplasm w/ concurrent BCR::ABL1 and JAK2 V617F ..the megekaryocyte morphology is clue to something beyond CML #mpnsm #PathOutPic 2/
BPDCN with perfect so-called “hand mirror” (red) and “pearl necklace” (black) morphology #BPDCN #PathOutPic 3/
Read 11 tweets
Jan 7
Happy to share our latest paper w/ @SibaElHussein as lead author, out today in @BMTjournal ⚡️Acquired WT1 mutations contribute to relapse of NPM1mut AML following allogeneic hematopoietic stem cell transplant  rdcu.be/cEuxv #hemepath #leukemia #hemepathMDA Image
WT1 mutations are present in ~7% of de novo AML, are typically Lof mutation involving exons 7-9 of the gene. They frequently (~15%) co-occur w/ NPM1mut & have detrimental impact in this setting, shown by @AkEisfeld and colleagues in  bit.ly/3eWQtXw @LeukemiaJnl Image
We studies a cohort of de novo NPM1-mut AML. 7% had concurrent WT1 mutations at baseline.  22% (15/67) relapsed; 4 (27%) with newly acquired Lof WT1-mut. Illustrated by @furudateken Image
Read 10 tweets

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