Discover and read the best of Twitter Threads about #leukemia

Most recents (12)

Happy to share our latest paper w/ @SibaElHussein as lead author, out today in @BMTjournal ⚡️Acquired WT1 mutations contribute to relapse of NPM1mut AML following allogeneic hematopoietic stem cell transplant  rdcu.be/cEuxv #hemepath #leukemia #hemepathMDA Image
WT1 mutations are present in ~7% of de novo AML, are typically Lof mutation involving exons 7-9 of the gene. They frequently (~15%) co-occur w/ NPM1mut & have detrimental impact in this setting, shown by @AkEisfeld and colleagues in  bit.ly/3eWQtXw @LeukemiaJnl Image
We studies a cohort of de novo NPM1-mut AML. 7% had concurrent WT1 mutations at baseline.  22% (15/67) relapsed; 4 (27%) with newly acquired Lof WT1-mut. Illustrated by @furudateken Image
Read 10 tweets
1/ Excited to share how T cell therapies kill #leukemia!! multi-omics + new #computational #singlecell tools for longitudinal analysis 👉unexpected answer! cell.com/cell-reports/f…

*👏* @elhamazizi! 🙏 @dpeer Cathy Wu @MDAndersonNews @CPRITTexas @ColumbiaBME @sloan_kettering
2/ We studied donor lymphocyte infusion (DLI) - an #Immunotherapy for relapsed #leukemia after #BMT & the #og of #celltherapy. Previously, we showed DLI reversed T cell exhaustion - but didn't know why/how/which T cells were responsible...
ashpublications.org/blood/article/…
3/ To address these ?'s, we modeled intraleukemic T cell dynamics by integrating longitudinal, multimodal data from ~100K T cells (!) during response (R) or resistance (NR: nonresponder) to DLI.
Read 18 tweets
Vandaag wordt voor de vijfde keer de internationale ‘AML World Awareness Day’ gehouden om aandacht te vragen voor acute myeloïde leukemie (#AML), een zeldzame vorm van bloedkanker. #NKRdata #leusm #leukemia #bloodcancer #KnowAML @IKNL @KNOW_AML @HematonNL (1/16)
AML treft momenteel ruim 750 patiënten per jaar in Nederland (zie figuur). Op basis van de internationale
RARECARE-definitie voor zeldzame kanker is AML een zeldzame kankersoort #NKRdata #leusm #bloodcancer #KnowAML @IKNL @KNOW_AML (2/16)
Volgens de RARECARE-definitie is een kankersoort zeldzaam als het minder dan zes nieuwe gevallen per 100.000 personen per jaar treft. Voor Nederland betekent dit dat een kankersoort zeldzaam is als er minder dan 1.021 nieuwe diagnoses per jaar zijn. (3/16)
Read 17 tweets
The Indian Institute of Technology (IIT) Indore has developed a cost-effective new asparaginase drug with lesser side-effects to treat Acute Lymphoblastic Leukemia (ALL). Asparaginase is an enzyme that is used as a medication, using the protein engineering approach.
ALL is a type of blood cancer representing nearly a quarter of cancer cases diagnosed among children. Around 25,000, new cases of ALL are diagnosed every year in India.
The institute said that repeated administration of asparaginase, currently to treat ALL, causes serious side-effects such as allergic reactions, neurotoxicity, among others.
Read 5 tweets
Depleted uranium bombs dropped on #Yemen do not help #leukemia

The Pediatric Leukemia Treatment Center in #Sanaa revealed an increase in cases of leukemia patients among children from 300 to 700 cases, as a result of the US-#Saudi use of internationally prohibited weapons,
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including the airstrikes in Attan and Naqum.

The airstrikes resulted in the injury of a thousand children in the rest of the governorates as well.

1/3

#YemenCantWait #YEMEN #YemenCantBreathe
1/3
The center’s director, Dr. Abd Al-Rahman al-Hadi, said that since its opening in 2014, the center has received about “1000” cases, 400 cases are frequently in the center, stressing that 30% of the cases died as a result of their delay in treatment and also as a result of the
1/4
Read 7 tweets
1/ Classic #opticneuritis is characterized by a sub-acute loss of vision in one Eye, with central #scotoma, pain on #eyemovement, positive #RAPD
- Fundus exam is usually normal
- Age range 15-45 years
2/Talking about #MOGAntibodies:
- More frequent in #pediatric population, Associated with #ADEM
- #MOG IgG serum titers depend on disease activity and is mainly from extrathecal origin, enters #CNS from systemic circulation and reaches CSF through passive diffusion or broken #BBB
Read 10 tweets
Meet Dr Yazad Irani, @Yaz_Sci, at @sahmriAU, the researcher paving the way to better outcomes in chronic myeloid #leukemia - by helping predict patient responses to #cancer therapy

A thread 👇

@AcademicChatter #chemotherapy #medicalresearch #precisionmedicine #CML #immunology Image
Our blood is composed of red blood cells, in charge of carrying oxygen; and white blood cells, whose main function is to help the immune response to fight infections and diseases.
Chronic myeloid leukemia (CML) is a blood cancer in which a subpopulation of white blood cells, known as granulocytes, grow out of control. Although new treatments have resulted in good patient outcomes for 80% of patients, the remaining 20% of patients do not respond to therapy.
Read 9 tweets
1 - $RAC @raceoncology

Bisantrene is a forgotten but effective #Leukemia drug from the 80s

It cured Leukemia in 2 kids without toxic effects on organs (particularly the heart) that prevent long term survival. Both now have children.

Modern trials are now planned.
@RaceOncology 2 - $RAC @raceoncology

Bisantrene is advanced from a safety and efficacy basis due to compelling Complete Response shown by multiple historic Phase II trials.

$RAC know that the drug is safe, effective and that it doesn’t damage key organs …

raceoncology.com/wp-content/upl…
@RaceOncology 3 - $RAC @raceoncology

We can get a perspective on the future value $RAC by looking at the history of Micromet and their development of their treatment for Acute Lymphocytic Leukemia (ALL) …
Read 22 tweets
Morning! In response to some of the tweets we're seeing online about @WWE and @WWERomanReigns we wanted to have a little chat about leukaemia/leukemia, relapse and perceptions of cancer. #WWE @davemeltzerWON
THIS.IS.A.THREAD!
Firstly, incredible news about Roman Reigns. Relapse is a scary reality for all leukaemia patients. Either fear of your cancer returning or having to face treatment for relapse. It's great to hear some positive news from a leukaemia patient.
The tweets we are seeing mainly centre around the idea of what a cancer patient should look like.

"How can he have hair?"
"How can he have not lost weight?"
"Why doesn't he look like a cancer patient?"
Read 19 tweets
#Tweetorial Just finished 4 weeks on the leukemia service at @UCCancerCenter. We saw a number of patients present with a new diagnosis of acute leukemia and hyperleukocytosis, our index of concern for the development of leukostasis was dependent on if they had AML or ALL.
In 1982 Lichtman et al wrote about hyperleukocytic leukemias. The leukocrit (packed WBC volume) was described in AML, ALL, and CLL. Due to the larger mean cell volume of myeloblasts, a higher leukocrit was observed in AML compared to ALL and CLL.
The pathophysiology of leukostasis is thought to be driven in part by blood viscosity. A higher leukocrit and hematocrit correlates with a higher blood viscosity.
Read 11 tweets
🔥 THREAD ⚠️ Spread the word. 👏👏👏
Massive #WoolseyFire Began On Contaminated Santa Susana Field Laboratory, Close to Site of Partial Meltdown
Statement by Physicians for Social Responsibility - Los Angeles (@PSRLA)
🔎 indybay.org/newsitems/2018…
#SimiValley #SSFL
🚨 Electric Substation at #SSFL Tripped 2 Minutes Before Fire Reported
The tremendously destructive #WoolseyFire has been widely reported as beginning “near” Santa Susana Field Laboratory (SSFL or Rocketdyne), but it appears that the fire began on the #Rocketdyne property itself.
"Cal Fire identifies the fire location as E Street and Alfa Road, a location that is in fact on Santa Susana Field Laboratory." -@PSRLA
#CalFire #SSFL #SimiValley #WoolseyFire
Read 22 tweets
🚨 THREAD 🔥 Spread the word. 👍🏼
Woolsey Fire Burns Nuclear Meltdown Site that State Toxics Agency Failed to Clean Up
Statement by Physicians for Social Responsibility - Los Angeles (@psrla)
#SSFL #WoolseyFire #SimiValley #OakPark #BellCanyon
⚠️🔎 indybay.org/newsitems/2018…
The #WoolseyFire began on the property of the contaminated Santa Susana Field Laboratory. #SSFL, a former nuclear and rocket engine testing site, is one of the most contaminated sites in the nation.
#SimiValley #OakPark #VenturaCounty #BellCanyon #WestHills #SFV
"Santa Susana Field Laboratory (#SSFL / #Rocketdyne) burned in the #WoolseyFire, threatening toxic exposures from contaminated dust, smoke, ash & soil. The Department of Toxic Substances Control (DTSC) denies risk that it created by delaying the long promised cleanup." -@PSRLA
Read 19 tweets

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