Thread by @firefoxx66

🎉CoVariants.org Update!🎉

22D (BA.2.75) is now available on CoVariants! It's visible as part of Per Country & Per Variant plots, on the shared mutation page - and of course, has a page of its own!

1/8

#BA275 #centaurus

covariants.org/variants/22D.O…

This is in line with the recent addition of 22D (BA.2.75) as a @nextstrain clade - read more on that below! 👇🏻

2/8

https://twitter.com/nextstrain/status/1550615442695151616

On the 22D page, you can read about some initial 22D / BA.2.75 work on things like immune-evasion, see a list of defining mutations, a plot of the variant growth, link to Aquaria protein viz, & see a list of other mutations present in the variant.

3/8

covariants.org/variants/22D.O…

There's also a link to the 22D / BA.2.75 @nextstrain focal build: nextstrain.org/groups/neherla…

Here, we can zoom in on the clade & get a closer look at how 22D sequences are distributed around the world, & their diversity.

4/8

On the Per Country page, 22D / BA.2.75 is currently only readily visible in India, where it likely originated & is most common, as well as a little in Japan. Over the next few weeks, it'll be possible to see if it grows in other countries.

5/8

covariants.org/per-country?co…

Finally, on the Shared Mutations page (very hard to capture in a picture now, with the Omicrons!), you can see how 22D's / BA.2.75's Spike mutations compare to other VoC, including its Omicron siblings.

6/8

covariants.org/shared-mutatio…

More information on 22D / BA.2.75 will become available in due course.
As always, CoVariants.org is open-source & we welcome your PRs & suggestions to add more studies & information to variant pages! (Or any error-catching!)

github.com/hodcroftlab/co…

7/8

As before, I've created a file for 22D / BA.2.75 mapping all defining mutations (relative to ancestral), including nuc->AA. This is available on CoV github!

Huge 🙏🏻 to all who helped check it! (Esp @DoktorYak & Anna N!) (Further feedback welcome!)

github.com/hodcroftlab/co…

8/8