Thread by @holmanm

1/ Ancel Keys has a lot to answer for. Researchers for the past 50 yrs have been beavering away in labs, desperate to find enough proof to covert the “lipid hypothesis” into the “Lipid FACT”. They have failed miserably, but in doing so have expanded
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2/ our knowledge of the biochemistry & physiology of the molecule CHOLESTEROL. Many researchers jumped the gun, & have discovered a type of Lipoprotein called small, dense (or type B) LDL which MAY be a risk factor for heart disease. Now here is the problem.
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3/ This small dense (type B ) LDL-C is WORSENED by the very diet recommended by those promoting the “lipid hypothesis”, and those who have hailed it for decades as the best diet to PREVENT heart disease. We are talking about the LOW FAT, high CARBOHYDRATE diet.
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4/ As it turns out, FAT, especially SATURATED fat DECREASES the amount of these small dense LDL particles, while the LOW FAT diet increases their number. The opposite of small dense LDL are large fluffy LDL particles, which are NOT harmful but are actually healthful.
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5/ Problem is that Statin drugs lower those too, & that's not all they do !!! Hmmm maybe we are on the wrong track here. When Cardios conclude that a therapeutic level of 100mg/dL for LDL is too 🔼 and needs to be even 🔽, we need to question their Lipochondriac herd mentality

**Convert** the lipid hypothesis !!