Thread by @sanamloghavi

@AaronGoodman33 Typical cytomorphology is characterized by “blasts” with hand mirror (red arrow, cytoplasm to the side) or pearl necklace (green arrow, small cytoplasmic vacuoles around nucleus) appearance #bpdcn #hemepath #RareDisease #WHOHEME 1/

@AaronGoodman33 Skin and lymph node are most common extramedullary sites of involvement. Skin infiltrate is usually dermal with an appreciable “grenz zone” (uninvolved band b/w dermis and epidermis).. Lymph node typically has diffuse or paracortical involvement #hemepath #WHOHEME #BPDCN

@AaronGoodman33 Bone marrow involvement can be interstitial, nodular and leukemic or a-leukemic. This was an example of a leukemic case @JoeKhouryMD and I published in @BloodJournal #bloodwork bit.ly/3JUBls7 @ASH_hematology #imagebank #WHOHEME #hemepath #bpdcn 3/

@AaronGoodman33 @JoeKhouryMD @BloodJournal @ASH_hematology Here is a summary of the immunophenotype for #BPDCN remember CD123/4/56 …. CD123 is universally positive (fortunately because we target with anti-CD123 for therapy) @doctorpemm .. CD56 may or may not be pos…so don’t be fooled if CD56 is not there. #WHOHEME #hemepath

@AaronGoodman33 @JoeKhouryMD @BloodJournal @ASH_hematology @doctorpemm most adult patients w/ BPDCN have BM clonal hematopiesis even without frank involvement by BPDCN as shown by @MahsaKhanlari @SaWangMD recently in @LeukemiaJnl go.nature.com/3djst34 #hemepath #WHOHEME #CHIP #RareDisease