Josh Wolfe Profile picture
Aug 20, 2022 59 tweets 20 min read Read on X
1/ Releasing NEW Lux quarterly letter to LPs

our theme: making MEANING + making MONEY

-‘Epistolary Imperative’
-next year 2023 will be “Twenty-Twenty-RE”
(RE-covery -constituting -pricing, -investing)
-“EXTENTIONALISM”
-information in prices
-matter that matters
-& much more… Image
2/ The point in writing these letters is to
-congeal observations of occurrences, information or events once concealed and now revealed
-crystallize ideas of what may be
-condense them into words for sharing (hey read this!) + signaling (hey we’re no fools!) Image
3/ MEANING can be powerfully created or destroyed

deeply embedded in objects + technologies
or coldly abstracted + decoupling from them…

Consider Derek DelGaudio’s ‘gold brick’ from In & Of Itself––only those in the know of his story see deep meaning in othewise ignored object
4/ Heirlooms, totems, old photos, tagged photos, saved voicemails, screenshotted texts––all contain the MEANING we MAKE

That’s the “Epistolary Imperative” at work––the pursuit of meaning in a stochastic universe… Image
5/ Observing an excess of excesses

an abundance of once-qualified optimism that begot unguarded greed + a scarcity of good governance + diligent discipline––required no complex calculations nor decimal-point precision…
6/
…only simple estimation that what WAS for a while––
WOULD NOT BE for much longer.
7/ ….There’s an old joke of a
curmudgeonly cassandra kvetch
muttering macabre missives
to the eye-rolling nuisance of his neighbors.

Before dying, he demanded his tombstone read only:

“I always knew this would happen.” Image
8/
We just had a “CORRECTION”––a euphemism for errors + poor decisions made in the past now evident

When P/E multiples fall📉 so do too-high prices
but history shows in recessions coincident with inflation further CORRECTIONS needed for overestimated earnings (lag in reporting) Image
9/ Over our past 6 letters our message was mix of
DEFENSIVE prudence
+ OFFENSIVE preparedness to pounce

-Capitalize on current capital markets
-Build warchest balance sheets
-Husband the cash
-Now consolidate
10/ While others pace may slow
our pace pulses to a steady beat

there is always something we can be doing
-an opportunity to seize
-a risk to reduce
-an internal process to improve

We may dial up or down certain strategies or emphasize certain sectors……or ‘DROP’ old ones
11/whether that is
-starting newcos or sourcing special situations
-teaming with top entrepreneurs who choose Lux
-investing in + expanding our team
-analyzing existing investments + adding value with good judgment + governance
-OR…
12/…or working to realize exits + returns for partners we feel fortunate to work for

In recent yrs–– we’ve distributed over a billion dollars to Lux’s trusted partners––

insignificant beyond an internal team nod, knowing it pales in comparison to our competitive ambitions…
13/ as Lux sets our sights soaring to return many multiples more in the years ahead Image
14/ Our PERSPECTIVE: keep PERSPECTIVE
follow TRENDLINES not HEADLINES

read PRESENT headlines +it may seem like
the WORST of times

read PAST history + it may seem like
the BEST of times

a climax of chaos may yet yield a denounment of detente
the ‘gold brick’ awaits discovery— Image
15/ After the tension, the muscle relaxes.

The house of cards collapses to the ground….
16/….but the gold-painted brick is out in the world, its full meaning and value to be discovered.
17/
2022 was the year of Entropic Apex

2023 will be “Twenty-Twenty-RE”––as in

…REconstituting the finance of innovation
…REdiscovering meaning of price
…REinforcing our strengths
…REconvening at work
…REthinking inflation
…REwearing suits😜
18/
…REinvesting in the frontier and ‘Matter that Matters’
…REcapturing human ingenuity.

Epistolary Imperative is about finding meaning in chaos
this LETTER is about two LETTERS (re)

+ the optimism that comes from
REcovering what was lost and
REmixing it into something new.
19/ REdiscovering the MEANING of PRICE

when everyone follows the same strategy
-prices synchronize
-underlying diversity breaks down + we get
-crushing crushing convergence
-as behaviors become similar
-amplifying + exacertbating market movements (like a stampeding herd) Image
20/ Prices should CONVEY information
information CARRIES inferences of expectations

It’s also true that party buses CARRY…drunken fools
And drunken fools CARRY…impaired judgment

Prices provide powerful feedback––and without feedback

CONFIDENCE grows faster than ACCURACY… Image
21/ Many will have LOST money––and GAINED experience

This time last year––90% of tech companies earned investors positive returns over the prior 12 months

Now–– 90% of tech companies have offered negative returns for investors.
22/ Almost every company (+ many people) is fighting some private struggle + is way more vulnerable in reality than it lets anyone else see or sense––

Consequences for being honest
are often as negative as the truth
So it’s usually a rational risk to bluff to keep up appearances Image
23/
It is usually a rational risk to BLUFF
to keep up appearances…
…even if it means they end up going ‘OVER THE BLUFF’

leading to the surprise shutdown + stepdown announcements we’ll likely see many more of in coming months…
24/
On companies or people down on their luck:

the naive may PRAY
knaves (and predators) may PREY
but the brave (and practical) will PARLEY

––and constructively help those in need
and do it both profitably + as trusted partners…
25/ on inflation, BIFLATION––
…and “treadmill class warfare”… Image
26/ "biflation" has been playing out––as the wealthy give up luxuries while the poor can barely afford to cover their needs.

“TREADMILL CLASS warfare”––
those who literally own one + can afford to work from home
VS.
those who figuratively are on them just trying to keep up
27/ Sellers of consumer discretionary stuff see excess inventories + markdowns + liquidations––ultimately deflationary

Hiring freezes + layoffs that employ the middle or upper-middle class may further shock or exacerbate deflationary forces in nice-to-have product categories… Image
28/ …particularly after so many during the pandemic pulled forward future demand + seized on the time + stimulus money + low interest rates to turn their homes into five-star spas + hotels

Last yr consumers RETURNED an entire DoD budget worth of stuff: $760 billion…
29/ Real risk may not be where all eyes are focused––employment + inflation but where they are not

Like not-widely covered segment of our financial plumbing which could lead to loss of solvency, liquidity and risk that radiates + ripples out with surprise… Image
30/
this may prove to be a Red Queen trap where––much like the character from Lewis Carroll’s Through the Looking-Glass––the poorest in our society need to run 2x as fast just to stay in place (making the employment picture look rosy obscuring reasons why so many NEED work)
31/ TECHNOLOGY can virtualize, simulate and abstract many things—but NOT our HUMAN essence. Image
32/
We lucky few––
We tribal social primates who read body language
laugh together
cry
commiserate
whisper secrets
roll eyes
hug + high-5
share meals + stories at the speed of sight + sound
without latency with real-time
360 spatial cognition
cant be algorithmically compressed
33/ Where you stand on the issue depends on where you sit.

Sure, if you are an owner, kingpin, boss, chief, el jefe or otherwise in a position of privileged power and you could retire, then you can work remotely.

Absence might make the heart grow fonder—it also might make….
34/ …junior employees who are pledging their lives + time more resentful. There’s something richly rewarding in the pay-it-forward moral duty of remembering we were once mentored––& mentoring those that may not realize they want or need it––investing valuable time in their dev..
35/ If you can phone it in, the world + other people may need you, but not really.

Situational cognition means being present + aware in situations…
36/Its why all sitcoms take place where we social primates convene
-coffee shops w/ friends
-taxi garages
-bars where everyone knows ur name
-the office
-classroom
-school
-hospital
all w/sudden bursts of strangers + serendipity
that create the 🎭 that makes life interesting
37/ Meaning-making + mission-critical jobs can’t be called in

from coveted beachfronts…
or converted basements…
38/
ask doctors, nurses, soldiers, stylists, sanitation workers, pilots, dentists, drivers, barbers, builders, teachers, athletes, mechanics, care- givers, contractors, butchers, bakers, candle-stick makers,
39/ …chefs, chemists, drug-hunters, pharmacists, mechanical engineers firefighters, boat captains, and factory workers…
40/
active intensity of AMBITION
beats laid back indolence of ENTITLEMENT

and diverse gathered groups w/shared goals
different lived-experiences + petty grievances
will achieve more together IN PERSON
than SILOED SELF-SEGREGATING individuals

CONVENIENCE will lose to CONVENING…
41/ On

the return of suits…

how groupthinkg + the herd homogenizes what we wear, watch + listen to

how new ideas always come from DIVERGENT DISSENTERS

And how the next 2 years are about REBUILDING, REFLECTION, RECONSTITUTION like 2000-2002 with range-bound markets Image
42/ Range-bound markets form from the fatigue of existing investors––and the tension between BULLISH THINKING x PATIENT PRUDENCE

Took 16 years for NASDAQ to reach 2000 highs again

Ensuing years saw rise of value investors, true biz analysts + celebrated long-short hedge funds… Image
43/One of Lux’s core strategies

is building + launching breakthrough competitively advantaged DE NOVO companies––

with 30 months of cash runway to emerge differentiated + desirable by future investors

Late-stage investors in 2025 may look VERY different
than in recent years… Image
44/
Lux = latin for light––each new breakthrough we back shines a spotlight on the KNOWN + reveals in the shadows of the circumference––new UNKNOWNS

Our knowledge can only be FINITE
Our ignorance must be INFINITE
in our infinite ignorance we are all EQUAL… Image
45/We expect our team to be nimble with curiousity + conviction in NEW areas others don’t yet appreciate
—and see what may be

While having keen + clear understanding of market conditions + expectations + liqudity of our peers
—and see what is. Image
46/
Lux ESCHEWS sector silios
yet ISSUES licenses for partners
—generalists all—to pursue periodic passions

We are only as ever good as our
-last investment
-last decision
-last interaction + impression made

We gain from intentional institutional design decisionsover many yrs Image
47/ To some ENVY is a SIN––to us it is part of a competitive ambition

for our partners + competitors to describe each functional area (finance, content, marketing, fundraising, corp dev, recruitng) + Lux as a whole as operating with excellence + to be enviably admired… Image
48/ Having been thru cycles of equity + credit bubbles and contractions––we see 3 main winning strategies

1. Bubble (give newcos 30 mos of cash)
2. Anti-bubble (fund late stage co’s at early stage prices)
3. Consolidation (co’s with cash warchest rollup sector) Image
49/ EXTENSIONALISM (not existentionalism)

undeniable ‘directional arrow of progress’

the extension + embodiment of our senses + cognition aided and offloaded onto technological systems with their own nervous systems + metabolic systems…

NO, not implants, cyborgs or androids— Image
50/ One of the most important current themes @ Lux

“EXTENSIONALISM”
“entitlement amnesia”—we forget that each technology had to discovered, go through periods of fiercely intense competition between inventors cajoling + convincing capital +consumers for adoption + amplification Image
51/ We already offload from our ORGANIC biology our ideas, memories, sights we see + sounds we hear (captured thru external sensors and stored in INORGANIC solid-state media)…

We offload our stomachs to stoves + appliances

*We WILL 100% offload organ production––and SOON(!)* Image
52/ 4 themes Lux sees BIG opportunity to seize on with the macro + market backdrop

1. Embodied Cognition (Amplified & Digitized Senses)

2. Tech-Enabled Aerospace + Defense

3. Emergent Networked Infrastructure

4. Enhanced Biotech & Tech of Science. Image
53/ On Lux’s investment theme of

-embodied congition (amplified + digitized senses)
aka “Extensionalism”

Lux funded ventures digitizing almost every human sense
-sight
-hearing
-taste
-touch
…and now SMELL! Image
54/Lux theme of

TECH-ENABLED AEROSPACE + DEFENSE

DEFENSE is of much more importance than OPULENCE

CCP + Putin have awoken the world as revisionist, nationalistic, dissent-suppressing, near-peer competitors and major military adversaries intent on undermining rule-based order— Image
55/
Consider:
more people have stepped foot on the moon than on the subsea surface of our planet

>90% of merch flows above sea (on container ships) while over 90% of info flows below sea (in fiber optic cables)

both need protection+assurance of security+freedom from sabotage Image
56/ On Lux theme of

EMERGENT NETWORKED INFRASTRUCTURE
from @FTX_Official to @VosborExchange to @Anchorage

Infrastructure has different temporal layers with some component changing + reconfiguring RAPIDLY
(software)

& other layers SLOWLY
(subsea fiber optics + outerspace sats) Image
57/ on Lux theme of
ENHANCED BIOTECH + ‘TECH of SCIENCE’

Computational biology accelerates discovery
BUT still requires wet labs, microscopes + making actual proteins outside of a computer… Image
58/ Just a price is a signal wrapped in an incentive…

…our technologies are MEANS
wrapped in MEANING––unforseen

The MORE widely spread any invented tech gets––
the MORE invisible it gets

We are BLIND to most of our tech unless it is BROKEN Image
59/
Lux Quarterly Letter Q2 2022

Full PDF (link to single file 📑) here👇
drive.google.com/file/d/1S3mmGr…

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More from @wolfejosh

Dec 5, 2025
1/Today at private investor gathering I pitched

LONG
Adobe (ADBE)

SHORT
basket of scientific publishers
Wiley
Elsevier
Springer Nature

AI overestimation oversold Adobe (down 40%)

AI underestimation along with 2 other catalysts is set to crack the oligopoly of publishers
2/ first $ADBE thesis then the short basket + weighting

reasonably clean dislocation in large-cap SW

Stock ~$325 (down ~40% from highs)

Mult compressed from ~40x to ~20x

EV/EBITDA ~11–12x (10yr low)

mkt sees "value trap" facing existential AI threat

I see category error
3/ I'll argue the consensus bear case:

"AI kills the seat" + commoditizes design

one AI-augmented designer replaces three

Adobe loses its moat, got disrupted, growth is slowing + it’s milking a hostage customer base...
Read 25 tweets
Nov 25, 2025
1/ We are ABSOLUTELY insanely lucky to be able to witness this conversation

MASTERCLASS in military + geopolitical strategy + Arab/Israeli conflict

@havivrettiggur's brilliance+ Dan Schueftan's realpolitik rationality

watch whole thing or pick any segment🤯
2/Key excerpts (summarized).
Hard to disagree with anything.

The Nature of the Enemy + "Barbarism"

The Definition of Barbarism: Barbarism is not just violence; it is a societal decision to value the death of the enemy over the lives of one's own children. When Hamas places weapons in tunnels but forces civilians to stay above ground during war, they are declaring that they do not care for their own survival, only the destruction of Jews.

The "Love of Death" is Literal: We must stop projecting Western rationalism onto enemies who openly declare, "You Jews will lose because you love life; we will win because we love death." This is not a slogan; it is a strategic doctrine that renders traditional deterrence mechanisms (like threat of death) ineffective.

The Danger of "Happy Wife, Happy Life" Geopolitics: The Western belief that economic prosperity ("a better life") leads to moderation is a fatal fallacy. The Second Intifada was launched when Palestinians had their best economic situation in history. You cannot buy off an ideology that considers killing Jews a higher calling than feeding children.

Culture is Deterministic: You cannot "de-radicalize" a society that does not want to change. Just as Libya’s failure is cultural rather than resource-based, Gaza’s failure is rooted in a culture where the only role models are those who kill Jews. The West’s refusal to discuss culture—viewing it as "progressive" to ignore it—blinds them to reality.
3/ (Summary continued) Strategic Realpolitik
Solutions are for Crossword Puzzles: In the Middle East, serious problems do not have solutions. The two-state solution is a fantasy for the "simpleminded." The only realistic strategy is combining "damage control" with the use of opportunity. If you are looking for a solution, you are looking for something that does not exist.

"Violent Maintenance" is the Only Peace: There will never be "peace" in the Western sense. There is only the constant destruction of the enemy's capacity to wage war. Israel must adopt a policy of "violent maintenance"—preemptively destroying capabilities (like factories and tunnels) before they can be used, regardless of the immediate diplomatic cost.

The "New York Times" Test: When fighting "barbarians," proportional response is a mistake. The response must be so overwhelming that it shatters the enemy's will. A good rule of thumb for Israel: "If the New York Times is not outraged, it's the wrong response.".

Western Aid Funds the Conflict: The West is funding its own enemies. Palestinians are the only refugees in history paid billions for generations to remain refugees. This funding teaches them that "behaving like barbarians" is a profitable business model that attracts French, British, and American support.
Read 5 tweets
Nov 6, 2025
1/ 🚨Today history in AI 💻+ biology 🧬was made!

CZI led by Mark Zuckerberg + Priscilla Chan who've admirably committed tens of billions (and the entirety of their wealth to CZI) has acquired Lux family co Evolutionary Scale––just 2yrs after it's founding at a great multiple...Image
2/ We first teamed w/ @alexrives cofounder of EvolutionaryScale ~10yrs ago

cofounding Lux family Kallyope (cutting-edge bioetch focused on gut-brain axis)

Alex had the prescience to see the future of bio was computer science + AI. So he got his PhD at NYU and then... Image
@alexrives 3/...then Alex went to Meta, built an absolute cutting-edge AI bio group and published work that competed with Alphafold/Deepmind.

I tried to convince him to spinout in late winter of 2022––but Meta was funding him too well...

BUT THEN! A twist of fate Image
Read 7 tweets
Oct 23, 2025
1/ why Quantum is BULLSHIT

"paving a path towards potential future"

like saying: 'Working towards possibility of maybe a thing that might one day be a breakthrough if a breakthrough were to maybe occur'

Here I assemble just 2005 to 2015 annual headlines or this BULLSHIT
2/ I could start in the 90s. But let's just go thru 20yrs of BULLSHIT

2005... Image
3/ 2006... Image
Read 18 tweets
Oct 8, 2025
1/ Revealing Lux's latest

a $101M launch of new cutting-edge biotech created from one the most important scientific breakthrus Lux has seen in many yrs!

NILO

control IMMUNE system 🦠
via NERVOUS system 🧠...

we stealth funded last yr before this NATURE paper got published👇Image
Image
2/ THE BIG IDEA?

Your brain has a direct hotline to your immune system.

Specific neurons in the vagus nerve detect inflammatory signals + then tell your brainstem to dial inflammation up or down.

When our team cut this connection immune responses went completely haywire!
3/ Here's HOW it works:

Think: biological thermostat for inflammation🌡️

Different vagal neurons respond to pro vs anti inflammatory cytokines (proteins that act as messengers in cell communication)

They relay this info to neurons––which then regulate the immune response...
Read 7 tweets
Aug 21, 2025
1/ Apple researchers just dropped NEW foundation model on BEHAVIORAL data from wearables.

Forget raw sensors—think steps, heart variability, gait

Trained on 2.5B hours via 162K people

Predicts age, sex, pregnancy, sleep like a crystal ball. Image
2/ Their new foundation model (WBM) trained not on noisy low-level sensor data––but on derived behavioral metrics via wearables

Outperforms raw sensor models in predicting sleep, injury, & infection.

When combined CRUSH it—predicting pregnancy w/ >90% accuracy. Image
3/ Contrarian take––Transformers may be overkill for everything

head-to-head on wearable data (Mamba-2) beat Transformers for health prediction. Simpler tokenization also won.

Lesosn: data’s unique physics (irregular, noisy)+ ignore the loud signals to hear the whispers––edge is in the architectureImage
Image
Read 4 tweets

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