We finish this week of Core Curriculum with a remarkable lecture on cardio-oncology from Dr. Gagan Sahni 
🔑take home points
1) Cancer Therapeutic Related Cardiac Dysfunction (CTRCD) defined as decrease in ❤️LVEF >10% from baseline to a value <55%
2) Type 1 cardiotoxicity such as from Anthracyclines 💉is dose related, cumulative, and irreversible and Dexrazoxane can reduce risk
1) Cancer Therapeutic Related Cardiac Dysfunction (CTRCD) defined as decrease in ❤️LVEF >10% from baseline to a value <55%
2) Type 1 cardiotoxicity such as from Anthracyclines 💉is dose related, cumulative, and irreversible and Dexrazoxane can reduce risk
3) Type 2 cardiotoxicity such as from trastuzumab leads to reversible cardiac dysfunction, is reversible, but is not dose related
4) GDMT💊can allow for continued dosing of trastuzumab in those with asymptomatic cardiac dysfunction
4) GDMT💊can allow for continued dosing of trastuzumab in those with asymptomatic cardiac dysfunction
5) Global longitudinal strain imaging🔭 allows for monitoring for subclinical cardiac dysfunction
6) Immune checkpoint inhibitor (ICI) myocarditis💔 occurs in approximately 2% of patients and occurs mostly in first 3 months
6) Immune checkpoint inhibitor (ICI) myocarditis💔 occurs in approximately 2% of patients and occurs mostly in first 3 months
7) Cardiac biomarkers🧪 and EKG changes are key tools for detection of ICI myocarditis
8) High dose corticosteroids💉are key for treatment
9) Coronary vasospasm is most common cardiotoxicity with 5-Fluorouracil
8) High dose corticosteroids💉are key for treatment
9) Coronary vasospasm is most common cardiotoxicity with 5-Fluorouracil
10) Nitrates, BB, and CCB may be key treatments💊 along with appropriate workup of CAD
#CardioTwitter #CardioOncology #MedTwitter
#CardioTwitter #CardioOncology #MedTwitter
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