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Vincent Rajkumar Profile picture
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Sep 1 • 4 tweets • 2 min read
Lenalidomide cost per month

$100 in India
$1000 in Europe
$18,000 in USA

No wonder lenalidomide is the #2 drug Medicare spends the most money on. #CostVR @DavidP4AD @policydeb
1/
Why?

17-20 generics in Europe and India bringing down the cost.

2-3 in USA but they are prevented from getting full market share.
2/
I led the first published phase II trial of Lenalidomide. So my interest in the cost is more than cursory. ashpublications.org/blood/article/…
Revlimid cost. drugs.com/price-guide/re…

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More from @VincentRK

Vincent Rajkumar Profile picture
Aug 31
Average life expectancy in America fell by 3 years due to Covid in 2020 and 2021.

Other developed countries did not see a hit in 2021 like the US did.

nytimes.com/2022/08/31/hea…
Life Expectancy fell by 6.5 years in Native Americans bringing their life expectancy to levels seen in America in 1944.

Life expectancy fell more in Black people and Hispanics in 2020.
COVID amplified disparities in healthcare access and availability in the US, leading to disparities in outcomes by race and ethnicity.
Read 5 tweets
Vincent Rajkumar Profile picture
Aug 27
Bispecifics for myeloma are promising. As I said earlier, I’d like them all get accelerated approval.

But as clinicians we must swiftly adjust dosing schedule & be watchful to risk of severe infections & other cancers that can occur with prolonged T cell suppression. #IMS2022
Overall survival is a composite endpoint. It not only depends on efficacy but also safety.

At this meeting talking to colleagues, I am increasingly aware of the risk of serious infections with these agents.
As @TomBmt133 pointed out severe infections and deaths due to infections with bispecifics and CART must be considered possibly related to therapy and not classified as unrelated.
Read 4 tweets
Vincent Rajkumar Profile picture
Aug 26
Dr. Thierry Facon making a compelling argument for autologous stem cell transplant for newly diagnosed myeloma. @Myeloma_Society #IMS2022
For high risk myeloma, its important to consider early transplant in the frontline setting.

For standard risk myeloma, we continue to prefer early transplant but in certain circumstance can delay transplant until first relapse accommodating patients’ wishes & life circumstances
For patients achieving MRD negative with induction therapy alone, early and delayed transplant gives similar outcomes. Thus an MRD directed approach to timing of transplant may the way of the future. Agree with @mvmateos #IMS2022
Read 6 tweets
Vincent Rajkumar Profile picture
Aug 26
This is the kind of lawsuit that makes people lose even more faith in the Pharmaceutical industry.

We have a pandemic costing millions of lives. And this is what their concern is? nbcnews.com/health/health-…
When so many including me were thanking Moderna, Pfizer, Astra Zeneca for rapidly producing vaccines, we were also defending you from those who alleged you were solely doing this for profit.

I cannot defend you any more.
I was disappointed and upset that companies were not transferring technology and resources to make vaccines available for poor countries.

I am even more upset now. It clearly looks like the profit you made in your mind was not adequate enough. Seriously?
Read 4 tweets
Vincent Rajkumar Profile picture
Aug 24
Although we have multiple options to treat myeloma, the number of highly effective drug classes are few and just not enough.

We continue to have an unmet need for relapsed myeloma. We continue to need accelerated approval by the FDA. @Rfonsi1 @NorthTxMSG #IMS2022 #IMS2022VR
1/ Image
We also need accelerated approval of multiple drugs of the same class because patients tolerate one better than the other, and sometimes one works better than the other. It is also important to have competition to foster more innovation and to have some effect on price.

2/
The fact we have made so much progress in myeloma does not mean we don’t need more drugs.

Myeloma remains a serious malignancy and we continue to have unmet needs. So I will continue to advocate for rapid approval of new drugs.
3/
Read 10 tweets
Vincent Rajkumar Profile picture
Aug 24
I will get the updated COVID vaccine boosters as soon as they are available. nbcnews.com/news/amp/rcna4…
COVID vaccines have saved countless lives. I’m glad to see vaccines modified to target new variants. ourworldindata.org/covid-deaths-b…
COVID vaccines were developed in record time against the origins wild strain 2 years ago. The virus has since mutated multiple times. We need the modified boosters to protect lives.
Read 4 tweets

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