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Ahmad Masri Profile picture
@MasriAhmadMD
Sep 4, 2022 • 9 tweets • 4 min read • Read on X
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The keynote address by Dr. Weyand discussing aging of the immune system #ISA_2022
The aging nation
Aging and diseases
This happens due to the aging of the immune system
Concepts in immune system aging
#ISA_2022
A classic example #ISA_2022
Mechanisms of T cell aging
#ISA_2022
The loss of T cell potential for self renewal #ISA_2022
Genetic and epigenetic mechanisms

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More from @MasriAhmadMD

Ahmad Masri Profile picture
May 13
The third presentation is by Greg Lewis focusing on the exercise response in #SEQUOIA #HCM
#HeartFailure2024 #CardioTwitter
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The exercise story and limitations in HCM

Image
Image
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PVO2
Ve/VCO2
Z score
Great results Image
Read 8 tweets
Ahmad Masri Profile picture
Sep 4, 2022
A different tale of making use of amyloids - the good side
#ISA_2022
Examples of good functional amyloids produced in nature #ISA_2022
A set of ways amyloids can be used by bacteria #ISA_2022
Read 7 tweets
Ahmad Masri Profile picture
Sep 4, 2022
Dr. Merlini talks on AL amyloidosis as a model for treating other amyloid disorders
#ISA_2022
Light chains cardiotoxicity in many studies
The age dependent process of handling LC #ISA_2022
Read 16 tweets
Ahmad Masri Profile picture
Dec 19, 2020
Preclinical and phase I data for $AKCA-TTR-LRx (second generation inotersen, ASO conjugated with GalNAc), currently being tested in CARDIO-TTRansform, the largest #ATTR #Amyloidosis trial to date. Tafamidis allowed without restrictions.

onlinelibrary.wiley.com/doi/epdf/10.10…

#cardiotwitter
Cojugation with GalNAc increased potency by 20-30x, allowing lower dose, lower frequency, less AE
Read 4 tweets
Ahmad Masri Profile picture
Jun 20, 2020
Thread/

There are many new exciting trials in transthyretin #amyloidosis – as we continue to enroll patients in the CARDIO-TTRansform trial, I thought I would highlight some of these trials in ATTR-CM

clinicaltrials.gov/ct2/show/NCT04…

#cardiotwitter Image
If you recall, 2 main approaches to treating ATTR #amyloidosis with approved drugs (figure credit @frederickruberg @maz_hanna )
1)Stabilizers: bind to the TTR tetramer to stabilize it. #tafamidis , AG-10, diflunisal
2)Silencers: Inotersen and Patisiran Image
tafamidis is prescribed to ATTR-CM pts & inotersen/patisiran for those with hATTR polyneuropathy
But – 2 main questions in ATTR-CM
1)Which is associated with better outcomes – silencer or stabilizer?
2)Is the combination of silencer+stabilizer superior to stabilizer only?
Read 13 tweets
Ahmad Masri Profile picture
Aug 7, 2019
Do you know the name of this sign on #echofirst?
#Cardiotwitter #ACCFIT
In 2006, Pieroni et al called this the "Binary Sign". They identified this myocardium appearance in 40 patients with Fabry's disease. When compared to patients with HCM, HTN, and healthy subjects, the sign had 94% sensitivity and 100% specificity. ( )ncbi.nlm.nih.gov/pubmed/16631007
Hypothesis: endomyocardial glycosphingolipids compartmentalization: 1) thickened glycolipid-rich endocardium 2)free glycosphingolipid subendocardial storage 3)an inner severely affected myocardial layer with a clear subendocardial-midwall layer gradient of disease severity.

Read 11 tweets

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