Discover and read the best of Twitter Threads about #amyloidosis
Most recents (14)
1) Welcome to a 🆕#accredited #tweetorial from @cardiomet_CE! Earn 0.5hr 🆓 CE/#CME by following this 🧵. Our expert faculty is Sanjiv J Shah MD @HFpEF, Cardiologist & Director, Northwestern HFpEF Program (hfpef.org). Director of Research, @NMCardioVasc
#FOAMed
#FOAMed
1b) .@HFpEF will be sharing the algorithm he uses to treat #HFpEF based on evidence we have thus far and his anecdotal experience treating patients over the past 16 years in the @NMCardioVasc HFpEF Clinic.
#CardioTwitter #MedEd @MedTweetorials #HeartFailure
#CardioTwitter #MedEd @MedTweetorials #HeartFailure
2) CE/#CMEcredit for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists 🇺🇸🇨🇦🇬🇧🇪🇺.
Statement of accreditation and faculty disclosures at cardiometabolic-ce.com/disclosures/.
FOLLOW US for accredited programs in #cardiometabolic space delivered wholly on Twitter!
Statement of accreditation and faculty disclosures at cardiometabolic-ce.com/disclosures/.
FOLLOW US for accredited programs in #cardiometabolic space delivered wholly on Twitter!
Summary
The COVID 💉 is comprised of mRNA encased in a lipid nanoparticle.
The mRNA is codon optimized with n1-methy-pseudoU and codes for a more durable spike protein.
It also contains dsDNA bacterial contaminants and an SV40 promoter.
See research of Kevin McKernan. >
The COVID 💉 is comprised of mRNA encased in a lipid nanoparticle.
The mRNA is codon optimized with n1-methy-pseudoU and codes for a more durable spike protein.
It also contains dsDNA bacterial contaminants and an SV40 promoter.
See research of Kevin McKernan. >
>
>
La FA es la arritmia mas común en #Amyloidosis #Cardiaca ya que existe una predisposición en el depósito de fibras amyloides en el atrio y en adición a un aumento de las presiones intra-atriales, resultando una dilatación.
🚩: FA + Bajo Voltaje + LVH
🚩: FA + Bajo Voltaje + LVH
Un 33% de estos pacientes presentaron trombo intracardiaco en autopsias, con un riesgo elevado de #shock cardiogenico.
El tratamiento es poco tolerada, ya que pueden provocar un estado de bajo gasto cardiaco y deterioro hemodinámico, por la fisiología restrictiva de la #AC
◼️Rythm: Amiodarona y Dofetilide
◻️Rate: bajas dosis de #BetaBlockers
🔲La ablacion por catéter a tenido grandes avances
◼️Rythm: Amiodarona y Dofetilide
◻️Rate: bajas dosis de #BetaBlockers
🔲La ablacion por catéter a tenido grandes avances
1) Welcome to Part 1 of a new #accredited #tweetorial in our series of educational programs on #hypertrophic #cardiomyopathy #HCM. Previous programs, still available for 🆓CE/#CME, are at cardiometabolic-ce.com/category/hcm/.
Now you can earn another 1.5hr credit by following ALL of this 🧵!
Now you can earn another 1.5hr credit by following ALL of this 🧵!
2) Our expert author is Sergio Kaiser MD PhD FACC FESC 🇧🇷🇮🇱 @pabeda1, cardiologist 🫀, Professor 🎓 of #InternalMedicine, Rio de Janeiro State University. He brings the general cardiologist's perspective to our #HCM discussions. Read and learn!
#FOAMed #CardioTwitter
#FOAMed #CardioTwitter
3) This program is supported by an unrestricted educational grant from Bristol Myers Squibb. Statement of accreditation and faculty disclosures at cardiometabolic-ce.com/disclosures/. Credit for #physicians #nursepractitioners #physicianassociates #nurses #pharmacists from @academiccme.
TRANSFORM-HF
What do we really know about efficacy of furosemide vs torsemide?
I am sure @robmentz and team have something to say about this 👊🏾
pubmed.ncbi.nlm.nih.gov/33714745/
#AHA #LBCT @AHAScience @noshreza
What do we really know about efficacy of furosemide vs torsemide?
I am sure @robmentz and team have something to say about this 👊🏾
pubmed.ncbi.nlm.nih.gov/33714745/
#AHA #LBCT @AHAScience @noshreza
Chlorthalidone versus HCTZ - pragmatic emr study by @Areefishani et al. After #SPRINTTrial I use chlorthalidone. What’s the evidence?
pubmed.ncbi.nlm.nih.gov/35390512/
#AHA #LBCT @AHAScience @noshreza
pubmed.ncbi.nlm.nih.gov/35390512/
#AHA #LBCT @AHAScience @noshreza
PPAR-alpha (e.g., fenofibrate, permafibrate) - Are triglycerides as a target out for CV event reduction, or just this mechanism?
pubmed.ncbi.nlm.nih.gov/30342298/ @APradhanBrigham to present 👊🏾
#AHA #LBCT @AHAScience @noshreza
pubmed.ncbi.nlm.nih.gov/30342298/ @APradhanBrigham to present 👊🏾
#AHA #LBCT @AHAScience @noshreza
@Parsifaler: "#Amyloidosis Induced By The #SARSCoV2 #SpikeProtein" ( wmcresearch.substack.com/p/transmissibi… ) #COVID19 #SARSCoV2 #VaccineSideEffects #EarlyTreatmentWorks
@JesslovesMJK: "Modified #SpikeProtein #RNA injection-induced #Amyloidosis?" ( jessicar.substack.com/p/modified-spi… ) #COVID19 #SARSCoV2 #VaccineSideEffects #EarlyTreatmentWorks
@medical_xpress: "Possible discovery of mechanism behind mysterious #COVID19 symptoms" ( medicalxpress.com/news/2022-05-d… ) #SARSCoV2 #VaccineSideEffects #EarlyTreatmentWorks #amyloidosis #SpikeProtein
The new epidemic: ATTR Cardiac #Amyloidosis: Current and Emerging Treatment Strategies
Follow/share this #JACCCardioOnc #Tweetorial!
🧵 1/
Follow/share this #JACCCardioOnc #Tweetorial!
🧵 1/
ATTR cardiac #amyloidosis: Tip of the iceberg - current and emerging therapies to manage and prevent #heartfailure.
#JACCCardioOnc #CardioOnc
2/
#JACCCardioOnc #CardioOnc
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➡️Light-chain amyloidosis (AL) and multiple myeloma (MM), are plasma cell (PC) malignancies with strikingly different clinical presentations 🥼🩺
➡️Success in🎯identifying these mechanisms has thus far been limited 👎
➡️Light-chain amyloidosis (AL) and multiple myeloma (MM), are plasma cell (PC) malignancies with strikingly different clinical presentations 🥼🩺
➡️Success in🎯identifying these mechanisms has thus far been limited 👎
(2/14)
➡️Alameda et al define a “transcriptional atlas” of normal PCs, AL amyloidosis, MM, and MGUS, identifying 13 different transcriptional patterns linking distinct PC dyscrasias to subsets of normal developing PCs, with diagnostic 🔬and prognostic implications
➡️Alameda et al define a “transcriptional atlas” of normal PCs, AL amyloidosis, MM, and MGUS, identifying 13 different transcriptional patterns linking distinct PC dyscrasias to subsets of normal developing PCs, with diagnostic 🔬and prognostic implications
The Webinar on "Monoclonal gammopathy and its significance for kidneys" is about to begin!
There is still time to test your knowledge by solving the @ISNeducation quiz ➡️ bit.ly/3j7U5cn
There is still time to test your knowledge by solving the @ISNeducation quiz ➡️ bit.ly/3j7U5cn
Starting now!
Webinar: "Monoclonal Gammopathy of Renal Significance - Clinical Perspective" with
@arzuvelix and Serhan Tuglular
#ISNwebinar
Webinar: "Monoclonal Gammopathy of Renal Significance - Clinical Perspective" with
@arzuvelix and Serhan Tuglular
#ISNwebinar
Welcome Dr @arzuvelix and Dr Serhan Tuglular
Webinar: "Monoclonal Gammopathy of Renal Significance -Clinical Perspective" with
#ISNwebinar
Webinar: "Monoclonal Gammopathy of Renal Significance -Clinical Perspective" with
#ISNwebinar
Preclinical and phase I data for $AKCA-TTR-LRx (second generation inotersen, ASO conjugated with GalNAc), currently being tested in CARDIO-TTRansform, the largest #ATTR #Amyloidosis trial to date. Tafamidis allowed without restrictions.
onlinelibrary.wiley.com/doi/epdf/10.10…
#cardiotwitter
onlinelibrary.wiley.com/doi/epdf/10.10…
#cardiotwitter
Cojugation with GalNAc increased potency by 20-30x, allowing lower dose, lower frequency, less AE
#ISA2020 Yesterday: Plenery Session on Diagnosis and Management of AL #amyloidosis chaired by @awechalekar and Stefan Schönland. Here is my take home message @AmyloidosisSupp @Amyloidosisfdn @Amyloidosis_ARC @AmyloidC @MayoAmyloid @amyloid_papers
@ADispenzieri talked about Diagnosis and work-up. Fat pad biopsy and bone marrow biopsy are able to determine the diagnosis of AL in 50-79%. In those cases an organ biospy is not necessary
@ADispenzieri at #ISA2020: 10 % of patients with Congo Red+ amyloid detection have TTR Amyloidosis and elevated FLC--> you need to determine the diagnosis by mass spec or IHC
1/9: A woman presents with diarrhea x 2 weeks that woke her from sleep. I love this fantastic framework for chronic diarrhea by @LindseyShipley8
2/9 We reviewed her admission EKG. What do you notice?
3/9 #MedTwitter: What’s your ddx for low EKG voltage? Think back to physiology. The space between EKG leads &❤️ can be filled with: 𝗳𝗹𝘂𝗶𝗱 (pleural/pericardial effusion), 𝗮𝗶𝗿 (PTX, COPD), 𝗳𝗮𝘁, 𝗶𝘀𝗰𝗵𝗲𝗺𝗶𝗮 (dead tissue) or 𝗶𝗻𝗳𝗶𝗹𝘁𝗿𝗮𝘁𝗶𝘃𝗲 processes.
Thread/
There are many new exciting trials in transthyretin #amyloidosis – as we continue to enroll patients in the CARDIO-TTRansform trial, I thought I would highlight some of these trials in ATTR-CM
clinicaltrials.gov/ct2/show/NCT04…
#cardiotwitter
There are many new exciting trials in transthyretin #amyloidosis – as we continue to enroll patients in the CARDIO-TTRansform trial, I thought I would highlight some of these trials in ATTR-CM
clinicaltrials.gov/ct2/show/NCT04…
#cardiotwitter
If you recall, 2 main approaches to treating ATTR #amyloidosis with approved drugs (figure credit @frederickruberg @maz_hanna )
1)Stabilizers: bind to the TTR tetramer to stabilize it. #tafamidis , AG-10, diflunisal
2)Silencers: Inotersen and Patisiran
1)Stabilizers: bind to the TTR tetramer to stabilize it. #tafamidis , AG-10, diflunisal
2)Silencers: Inotersen and Patisiran
tafamidis is prescribed to ATTR-CM pts & inotersen/patisiran for those with hATTR polyneuropathy
But – 2 main questions in ATTR-CM
1)Which is associated with better outcomes – silencer or stabilizer?
2)Is the combination of silencer+stabilizer superior to stabilizer only?
But – 2 main questions in ATTR-CM
1)Which is associated with better outcomes – silencer or stabilizer?
2)Is the combination of silencer+stabilizer superior to stabilizer only?
16/
Sorry @venkmurthy @onco_cardiology @IbrahimMSaeed1 and others but #WhyCMR is not on this algorithm. Though, it is used frequently as a “catch all” diagnostic test for various cardiomyopathies.
Sorry @venkmurthy @onco_cardiology @IbrahimMSaeed1 and others but #WhyCMR is not on this algorithm. Though, it is used frequently as a “catch all” diagnostic test for various cardiomyopathies.
17/
I use cardiac MRI frequently for non-invasive evaluation in AL. Still, you will need biopsy proof of amyloid somewhere in the body before most hematologists will treat.
Amazing summary image by NAC group in London: ncbi.nlm.nih.gov/pubmed/29929616
I use cardiac MRI frequently for non-invasive evaluation in AL. Still, you will need biopsy proof of amyloid somewhere in the body before most hematologists will treat.
Amazing summary image by NAC group in London: ncbi.nlm.nih.gov/pubmed/29929616
18/
SPECIAL POPULATIONS
Aortic stenosis: ATTR and AS coexist in the elderly. Common cause of LFLG AS. We have described this @maz_hanna @ClevelandClinic as well as @JoaoLCavalcante, NAC, Columbia, +more. 16% of TAVRs and 30% of LFLG AS with EF<50% may have ATTR.
SPECIAL POPULATIONS
Aortic stenosis: ATTR and AS coexist in the elderly. Common cause of LFLG AS. We have described this @maz_hanna @ClevelandClinic as well as @JoaoLCavalcante, NAC, Columbia, +more. 16% of TAVRs and 30% of LFLG AS with EF<50% may have ATTR.
