Discover and read the best of Twitter Threads about #amyloidosis

Most recents (14)

1) Welcome to a 🆕#accredited #tweetorial from @cardiomet_CE! Earn 0.5hr 🆓 CE/#CME by following this 🧵. Our expert faculty is Sanjiv J Shah MD @HFpEF, Cardiologist & Director, Northwestern HFpEF Program ( Director of Research, @NMCardioVasc
#FOAMed Image
1b) .@HFpEF will be sharing the algorithm he uses to treat #HFpEF based on evidence we have thus far and his anecdotal experience treating patients over the past 16 years in the @NMCardioVasc HFpEF Clinic.
#CardioTwitter #MedEd @MedTweetorials #HeartFailure
2) CE/#CMEcredit for #physicians #physicianassociates #nurses #nursepractitioners #pharmacists 🇺🇸🇨🇦🇬🇧🇪🇺.
Statement of accreditation and faculty disclosures at
FOLLOW US for accredited programs in #cardiometabolic space delivered wholly on Twitter!
Read 34 tweets

The COVID 💉 is comprised of mRNA encased in a lipid nanoparticle.
The mRNA is codon optimized with n1-methy-pseudoU and codes for a more durable spike protein.
It also contains dsDNA bacterial contaminants and an SV40 promoter.
See research of Kevin McKernan. >
Read 17 tweets
La FA es la arritmia mas común en #Amyloidosis #Cardiaca ya que existe una predisposición en el depósito de fibras amyloides en el atrio y en adición a un aumento de las presiones intra-atriales, resultando una dilatación.
🚩: FA + Bajo Voltaje + LVH Image
Un 33% de estos pacientes presentaron trombo intracardiaco en autopsias, con un riesgo elevado de #shock cardiogenico.
El tratamiento es poco tolerada, ya que pueden provocar un estado de bajo gasto cardiaco y deterioro hemodinámico, por la fisiología restrictiva de la #AC

◼️Rythm: Amiodarona y Dofetilide

◻️Rate: bajas dosis de #BetaBlockers

🔲La ablacion por catéter a tenido grandes avances
Read 6 tweets
1) Welcome to Part 1 of a new #accredited #tweetorial in our series of educational programs on #hypertrophic #cardiomyopathy #HCM. Previous programs, still available for 🆓CE/#CME, are at
Now you can earn another 1.5hr credit by following ALL of this 🧵!
2) Our expert author is Sergio Kaiser MD PhD FACC FESC 🇧🇷🇮🇱 @pabeda1, cardiologist 🫀, Professor 🎓 of #InternalMedicine, Rio de Janeiro State University. He brings the general cardiologist's perspective to our #HCM discussions. Read and learn!
#FOAMed #CardioTwitter
3) This program is supported by an unrestricted educational grant from Bristol Myers Squibb. Statement of accreditation and faculty disclosures at Credit for #physicians #nursepractitioners #physicianassociates #nurses #pharmacists from @academiccme.
Read 68 tweets

What do we really know about efficacy of furosemide vs torsemide?

I am sure @robmentz and team have something to say about this 👊🏾

#AHA #LBCT @AHAScience @noshreza
Chlorthalidone versus HCTZ - pragmatic emr study by @Areefishani et al. After #SPRINTTrial I use chlorthalidone. What’s the evidence?

#AHA #LBCT @AHAScience @noshreza
PPAR-alpha (e.g., fenofibrate, permafibrate) - Are triglycerides as a target out for CV event reduction, or just this mechanism? @APradhanBrigham to present 👊🏾

#AHA #LBCT @AHAScience @noshreza
Read 8 tweets
The new epidemic: ATTR Cardiac #Amyloidosis: Current and Emerging Treatment Strategies

Follow/share this #JACCCardioOnc #Tweetorial!

🧵 1/
ATTR cardiac #amyloidosis: Tip of the iceberg - current and emerging therapies to manage and prevent #heartfailure.

#JACCCardioOnc #CardioOnc

ATTR #amyloidosis: Clinical progression and management strategies 👇

#JACCCardioOnc #CardioOnc

Read 5 tweets
#tweetorial 🧵
🚩AL & MM - Transcriptional patterns link common causal root with differing behaviours
➡️Light-chain amyloidosis (AL) and multiple myeloma (MM), are plasma cell (PC) malignancies with strikingly different clinical presentations 🥼🩺
➡️Success in🎯identifying these mechanisms has thus far been limited 👎
➡️Alameda et al define a “transcriptional atlas” of normal PCs, AL amyloidosis, MM, and MGUS, identifying 13 different transcriptional patterns linking distinct PC dyscrasias to subsets of normal developing PCs, with diagnostic 🔬and prognostic implications
Read 19 tweets
The Webinar on "Monoclonal gammopathy and its significance for kidneys" is about to begin!
There is still time to test your knowledge by solving the @ISNeducation quiz ➡️
Starting now!
Webinar: "Monoclonal Gammopathy of Renal Significance - Clinical Perspective" with
@arzuvelix and Serhan Tuglular
Welcome Dr @arzuvelix and Dr Serhan Tuglular
Webinar: "Monoclonal Gammopathy of Renal Significance -Clinical Perspective" with

Read 44 tweets
Preclinical and phase I data for $AKCA-TTR-LRx (second generation inotersen, ASO conjugated with GalNAc), currently being tested in CARDIO-TTRansform, the largest #ATTR #Amyloidosis trial to date. Tafamidis allowed without restrictions.…

Cojugation with GalNAc increased potency by 20-30x, allowing lower dose, lower frequency, less AE
Read 4 tweets
#ISA2020 Yesterday: Plenery Session on Diagnosis and Management of AL #amyloidosis chaired by @awechalekar and Stefan Schönland. Here is my take home message @AmyloidosisSupp @Amyloidosisfdn @Amyloidosis_ARC @AmyloidC @MayoAmyloid @amyloid_papers
@ADispenzieri talked about Diagnosis and work-up. Fat pad biopsy and bone marrow biopsy are able to determine the diagnosis of AL in 50-79%. In those cases an organ biospy is not necessary
@ADispenzieri at #ISA2020: 10 % of patients with Congo Red+ amyloid detection have TTR Amyloidosis and elevated FLC--> you need to determine the diagnosis by mass spec or IHC
Read 10 tweets
1/9: A woman presents with diarrhea x 2 weeks that woke her from sleep. I love this fantastic framework for chronic diarrhea by @LindseyShipley8
2/9 We reviewed her admission EKG. What do you notice? Image
3/9 #MedTwitter: What’s your ddx for low EKG voltage? Think back to physiology. The space between EKG leads &❤️ can be filled with: 𝗳𝗹𝘂𝗶𝗱 (pleural/pericardial effusion), 𝗮𝗶𝗿 (PTX, COPD), 𝗳𝗮𝘁, 𝗶𝘀𝗰𝗵𝗲𝗺𝗶𝗮 (dead tissue) or 𝗶𝗻𝗳𝗶𝗹𝘁𝗿𝗮𝘁𝗶𝘃𝗲 processes.
Read 10 tweets

There are many new exciting trials in transthyretin #amyloidosis – as we continue to enroll patients in the CARDIO-TTRansform trial, I thought I would highlight some of these trials in ATTR-CM…

#cardiotwitter Image
If you recall, 2 main approaches to treating ATTR #amyloidosis with approved drugs (figure credit @frederickruberg @maz_hanna )
1)Stabilizers: bind to the TTR tetramer to stabilize it. #tafamidis , AG-10, diflunisal
2)Silencers: Inotersen and Patisiran Image
tafamidis is prescribed to ATTR-CM pts & inotersen/patisiran for those with hATTR polyneuropathy
But – 2 main questions in ATTR-CM
1)Which is associated with better outcomes – silencer or stabilizer?
2)Is the combination of silencer+stabilizer superior to stabilizer only?
Read 13 tweets
Sorry @venkmurthy @onco_cardiology @IbrahimMSaeed1 and others but #WhyCMR is not on this algorithm. Though, it is used frequently as a “catch all” diagnostic test for various cardiomyopathies.
I use cardiac MRI frequently for non-invasive evaluation in AL. Still, you will need biopsy proof of amyloid somewhere in the body before most hematologists will treat.

Amazing summary image by NAC group in London:

Aortic stenosis: ATTR and AS coexist in the elderly. Common cause of LFLG AS. We have described this @maz_hanna @ClevelandClinic as well as @JoaoLCavalcante, NAC, Columbia, +more. 16% of TAVRs and 30% of LFLG AS with EF<50% may have ATTR.
Read 9 tweets

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