Thread by @RafaJArguello

📢 Very 🔥 out of press!

Our paper about #metabolic reprogramming in DC during development and activation.

OPEN ! (enjoy) nature.com/articles/s4146…
#natcomms

DC can 🔥 or🧯adaptive immune responses (IR). Also Metabolism can 🔥 or🧯 IR.

Little "zoom" on this story:👇

🧵

🤔 What are the metabolic profiles associated to inflammatory🔥 and tolerogenic 🧯👫 monocyte derived DCs?

Tools 🛠️ developed by us @SCENITHmetab (@CIML_Immunology), @felixjhartmann and others allowed us to address those questions.

(SCENITH)

https://twitter.com/RafaJArguello/status/1333804859364052994

👆
- A dramatic metabolic switch in monocytes one day after they start differentiation (top right).

Also:
How metabolic heterogeneity links to surface markers heterogeneity by #SCENITH (@SCENITHmetab & #scMEP in 🧯or 🔥 conditions

Check the nature.com/articles/s4146…

....

Also:

- What metabolic signaling pathways regulate DC 🔥🧯function and how this can be measured by flow cytometry @CytekBio

Based on what we know from Macrophages and T cells and now on DCs (tags). Measuring the metabolic profile of immune cells ...

https://twitter.com/lynchielydia/status/1351256886075662340

... can tell us about their functional state and their metabolic capacities. This in turn can be a great tool to control the quality and follow the state of cells used for #immunotherapy

We hope that tools like SCENITH will continue to help to move forward in this direction.

This study was spearheaded by the great (twitter less) Adamik Juraj and directed by Lisa Butterfield & me.

An amazing collaborative work with +contributions of Paul Munson; including my dear colls and young PIs @AlexisCombes @FelixHartmann ; P.Pierre @Bendall_Lab & @MaxKrummel