Discover and read the best of Twitter Threads about #metabolic

Most recents (17)

Thread on #Magnesium and why it is fundamental for our #health. #micronutrients
..many people debate the various ratios of #macronutrients like #protein, #fat, and #carbohydrates in their diet to find their optimal health. Which is great as we are #bioindividuals but most miss out on #micronutrients like #vitamins and #minerals.
The way our bodies are able to use the #macronutrients is fully dependent on how our #enzymatic pathways are influenced by various #micronutrients. One of the most important amongst is #magnesium.
Read 19 tweets
Picking up where @rita_rebollo left, we spent a couple of years annotating and analyzing the rest of the rice #weevil #genome (ok, the 15% left after removing repeats)! All info presented here is on the huge Additional file 2 in @BMCBiology doi.org/10.1186/s12915… 1/n
@VargasChavezC and @gabaldonlab performed a comprehensive #phylogenomic analysis of the rice #weevil and found that this insect has a high gene expansion rate when compared to other beetles. 2/n Image
With the invaluable help of the SymT group from @INRAE_UMR_BF2I we have also reconstructed the #metabolic pathways from both #symbiotic partners. Specific losses of enzymes in the #weevil genome are limited while its #endosymbiont has suffered much more degradation. 3/n
Read 13 tweets
In our recent review on #LongCovid/PASC we bring up the possibility that dysbiosis or imbalance of host #microbiome communities (in ecosytems such as the gut, lungs, or oral cavity) might contribute to at least some LongCovid symptoms: frontiersin.org/articles/10.33…
2/ More specifically immune dysregulation driven by #SARS-CoV-2 might allow pathobionts (bacteria capable of both commensal + virulent acitivty) in the gut, mouth, or other body sites to collectively shift towards a state of imbalance + pro-inflammatory gene/metabolite expression
3/ Conversely, b/c composition + activity of the microbiome can influence host susceptibility and ongoing control of #viral pathogens, exisiting microbiome dysbiosis in a range of body sites may serve as a form of predisposition to LongCovid
Read 11 tweets
This interesting study found that skeletal #muscle cells of #ME/CFS patients showed a decrease in oxidative phosphorylation (a metabolic pathway used by #mitochondria to generate #energy). In simple terms, that caused the cells to have a dysregulated #metabolism.
2/ Not mentioned in the paper, but important to consider, is that most well-studied #viral + bacterial #pathogens “hijack” the metabolism of the cells they infect in a manner that can result in decreased oxidative phosphorylation (or similar changes in cell energy pathways).
3/ In simples terms, these #pathogens “hijack” cell metabolism to “pull” substrates out of the human mitochondrial energy pathways...and use the substrates (lipids, fatty acids, amino acids) for their own #nutritional and replication purposes!
Read 6 tweets
Excited to share our publication on #inflammation, #metabolic dysregulation, & #depression symptoms now out @JAMAPsych!

This is work by @Binder_Lab, Janine Arloth, @mgeorgakis1, @and_Ramses_II, Symen Ligthart, & @golam_khandaker.

Tweetorial below

jamanetwork.com/journals/jamap…
In this project we studied symptom heterogeneity in #depression, which is highly prevalent and may hamper ongoing research efforts in depression. @caina89, @karmelchoi, & @EikoFried have recently conducted an excellent review on the genetic side of this:
academic.oup.com/hmg/article/29…
In our study, we focused on the association of #inflammation w/ specific depressive symptoms, which was previously largely described in cross-sectional studies, but also some longitudinal & polygenic risk score work.
Read 14 tweets
#DysConf2020 Neurogastroenterologist @LauraAPace talking about the multidisciplinary #EDS clinic she helped to set up -- time to dx for the geog area was v long, time to being seen by a clinical geneticist for referred pts was THREE to FIVE YEARS.
Wanted to track comorbid disease burden/syndrome burden. Clinical phenotype was often more severe than the diagnostic label suggested (for hEDS, etc). Need a more comprehensive dx for these patients.
The clinic ultimately didn't work bc, when the clinicians from the specialist EDS clinic recommended patients be followed up with formal screening for potential autonomic dysfunction,& passed on the testing/mgt outline to their primary care physicians...
Read 12 tweets
A new research study in @bmj_latest doi.org/10.1136/bmj.m3… finds the risk to die early (<70yrs) increases with irregularity & length of women’s #menstrualcycle irregularity, with premature mortality mostly due to #cardiovasculardisease. What's it mean for women with #PCOS? 1/13
PCOS affects 10% of women worldwide & irregular menstrual cycles are a common symptom. Many of the women in this study likely have PCOS. Understandably, the higher rates of premature mortality reported will be worrying to women with PCOS. But what causes period irregularity? 2/13
Increased levels of male hormones #androgens are a cause of irregular periods (see: doi.org/10.1177/204201…; doi.org/10.1210/en.201…) and also impact on pancreatic beta cell function (doi.org/10.2337/db20-0…) causing #insulinresistance 3/13
Read 14 tweets
1/3
The devil is in the 'detailed' #drug history #clinical
22 yr male, underweight
Teetotaler
Fatigue, appetite loss
Liver test AST 400 ALT 600
Viruses negative
Liver #biopsy 👇Severe #fatty #liver #disease, Mallory Denk++
#livertwitter #pathology #MedTwitter #MedStudentTwitter Image
2/3
The culprit 👇#Ayurveda #medicine
#Ayurvedic jam with butter, honey, milk as base given for premarital #weight gain! 3 months after stopping, liver tests normal
Consider #drug induced fatty liver in #patients. Not everyone is #metabolic #syndrome
#pseudoscience #Nash #nafld Image
3/3
Common drugs causing fatty liver
Steroids, Valproate
Inj Tetracycline
#HIV #AIDS meds NRTIs
Rare - methotrexate, chemodrugs irinotecan, 5FU, tamoxifen
Also important is Amiodarone
Herbals with #Margosa oil too
Remember #alternative meds rich in fats are important causes too.
Read 3 tweets
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Read 6 tweets
MEET THE RESEARCHER,
Dr Shelley Gorman of @UWAresearch @uwanews and @telethonkids investigating how sun exposure may improve the well-being of people who are overweight or diabetic.

A thread 👇👇

#sunexposure #diabetes #obesity #sun #research #cardiovascular #metabolic Image
Over one quarter of Australian children are obese or overweight. What can we learn from science to reduce this alarming statistic?
Modifiable lifestyle factors such as exercise have the potential to improve the well being of many overweight or obese children and adults – but something as simple as sun exposure may be an equally accessible, equitable, and inexpensive tool.
Read 10 tweets
I'd like to point out that while the resolution of a #chronicillness was striking, what is more striking is the rapid descent into Wernicke's in a hospitalized 90 yo woman - a descent so striking that she went into respiratory distress necessitating a #ventilator. 1/
Upon giving #IVthiamine per a #wernickesprotocol at 200mg 3X p/d she woke up, after just 2 days of thiamine treatment, and the ventilator was removed. What could this tell us about the use of thiamine in #COVID19? Perhaps the cluster symptoms we see are really just a variation 2/
thiamine deficiency - one that is being missed by practitioners everywhere because we're not looking at the #mitochondria for answers. 3/
Read 8 tweets
22nd February was #WorldEncephalitisDay. @mheduNIMHANS and @encephalitis it was an opportunity to engage with medical students and professionals to talk about various aspects of #encephalitisinIndia. 1/n
We took stock of the outbreaks of acute encephalitis syndrome in India, the first recorded Japanese encephalitis outbreak, in 1955 in Vellore to the Nipah outbreak in 2018 in Kerela, and those that occur annually in multiple states of N and NE India with Prof. V Ravi.
Revisited the success of the Japanese encephalitis vaccine in South India, the impact of vaccine shortages and understood how mosquito (vector) behaviour influences control measures with Dr. Ravikumar
Read 13 tweets
Glad to see #ME/CFS mentioned as a disease potentially connected to immunometabolic reprogramming of host cells. But #pathogen activity in ME/CFS is severely understudied. For example, no team has yet searched for organisms in patient cerebrospinal fluid
2/ Further, numerous outbreaks of the disease have occurred that were directly linked to #enterovirus/coxsackie #viruses + autopsy studies of patients w/ ME/CFS have identified enteroviruses in patient brain tissue + stomach biospy samples: ncbi.nlm.nih.gov/pubmed/17872383
3/ Moreover early studies on #microbiome activity in ME/CFS indicate dysbiosis of #bacterial communities in patients w/ the #disease, w/ one study noting an increase in bacterial phyla in patient blood after a symptom-provocation challenge: ncbi.nlm.nih.gov/pubmed/26683192
Read 11 tweets
What if I told you that #BigTech and #SocialMedia platforms are manipulating you, steering you toward #Health information that they think is right, rather than letting you evaluate content for yourself?

Commentary by @MaryamHenein (Thread 👇) theepochtimes.com/google-censors…
Accredited professionals, meanwhile, who stand for #Health freedom and who criticize Big Anything, are losing posting privileges, getting banned, being buried, finding themselves deranked, and getting digitally assassinated.
Content is literally disappearing from the Internet along with our #Health choices.

It sounds conspiratorial because it is. Independent #Journalists and health experts are blowing the whistle. But it’s become a silent one.
Read 94 tweets
Yay we are go! @ryanfseipke introducing the best #microbio19 session 'The biological and chemical tales of the antibiotic makers' on behalf of fellow organizers @kate_duncan @lore_fermar and myself and invite all session delegates to social from 9pm onwards in The Dirty Onion pub
First speaker of the best #microbio19 session is @MattHutchings10 on #antbiotics
.@MattHutchings10: covers 10years of amzing chemical ecology and (micro)biology, with multilevel multitrophic interactions #Microbio19
Read 17 tweets
Thread:

The 10 publications below provide scientific evidence that patients with #MECFS have #brain abnormalities in #neuroinflammation, #metabolism, #neurological connections and blood perfusion

#pwME suffer from #chronicillness

#pwME are #SickNotWeak
1. These studies “provide evidence of #neuroinflammation in #MECFS.. as well as evidence of the possible contribution of neuroinflammation to the pathophysiology of #MECFS

#pwME

jnm.snmjournals.org/content/55/6/9…
2. This Australian study found abnormalities in the #brain MRIs and peripheral Blood Pressure and Heart Rate in #MECFS patients including the Vasomotor centre, midbrain and hypothalamus

#pwME

sciencedirect.com/science/articl…
Read 14 tweets

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