We made #AlphaFold dream of new protein assemblies, used #ProteinMPNN to bring it back to reality, and the results were stunning! (1/5) science.org/doi/10.1126/sc…
Using #AlphaFold hallucination, we generated protein assemblies with up to C42 symmetry and validated 10 designs (7xtal/3cryoEM) – these structure differ significantly from anything the network has seen during training! (2/5) 
What does this image and these proteins have in common? Activation maximization initially lead to adversarial sequences (insoluble), but #ProteinMPNN gave these structures a new life in the wetlab! (image: en.wikipedia.org/wiki/DeepDream) (3/5)
An amazing scientific journey with incredible people! @LFMilles ACourbet @RobertRagotte @JustasDauparas @EliasKinfu @SamTipps @RyanDKibler @minkbaek et al.
Try it yourself here:
AF2H: github.com/bwicky/oligome…
ProteinMPNN: github.com/dauparas/Prote…
(4/5)
Try it yourself here:
AF2H: github.com/bwicky/oligome…
ProteinMPNN: github.com/dauparas/Prote…
(4/5)
🚨 Don't miss the #ProteinMPNN paper by @JustasDauparas – a quantum leap for the field of protein design! (5/5)
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
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