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Basile Wicky Profile picture
Basile Wicky
@BasileWicky
Protein design & synthetic biology • Incoming asst. prof. @ETH_BSSE • Currently post-doc Baker lab @UWproteindesign
Sep 16, 2022 • 5 tweets • 5 min read
We made #AlphaFold dream of new protein assemblies, used #ProteinMPNN to bring it back to reality, and the results were stunning! (1/5) science.org/doi/10.1126/sc… Using #AlphaFold hallucination, we generated protein assemblies with up to C42 symmetry and validated 10 designs (7xtal/3cryoEM) – these structure differ significantly from anything the network has seen during training! (2/5)