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Chise 🧬🧫🦠🔬💉🥼🥽 Profile picture
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Sep 20 • 11 tweets • 3 min read
Published in NEJM. Peer-reviewed. Large sample size. Sound methodology. Moderna's bivalent booster vaccine demonstrated SIGNIFICANTLY higher neutralizing antibody responses in ALL participants REGARDLESS of prior infection, against ALL variants of concern INCLUDING Omicron.🧵
Source:
•nejm.org/doi/full/10.10…
PLEASE NOTE. SUPERIORITY CONTINUED A MONTH AFTER ADMINISTRATION, NOT ONLY FOR A MONTH. Just wanted to clarify that statement before comments started popping up. In addition, this study is in regards to NEUTRALIZING ANTIBODY RESPONSES ONLY. Let’s continue.
THIS thread is in regards to clinical data for mRNA-1273.214, which in collaboration with NIAID, is Moderna’s updated bivalent booster incorporating more Omicron-specific mutations (mRNA-1273.214) which combines the currently authorized Moderna COVID-19 booster (mRNA-1273)
with their Omicron-specific booster (mRNA-1273.529). This phase 2/3 study evaluated the safety and immunogenicity of the bivalent vaccine candidate mRNA-1273.214 (equal mRNA amounts of ancestral SARS-CoV-2 and Omicron variant spike proteins) as 50-μg (n=437) first or second Image
booster doses after the mRNA-1273 primary series. The mRNA-1273.214 booster (50μg) elicited an 8-FOLD BOOST in neutralizing geometric mean titers against Omicron among baseline seronegative participants, successfully meeting pre specified endpoints for superiority against Omicron
Among seronegative participants one month after administration, the neutralizing GMT against ancestral SARS-CoV-2 for mRNA-1273.214 was 5977, compared to GMT for mRNA-1273 of 5649. The GMT against Omicron for mRNA-1273.214 was 2372 compared to GMT for mRNA-1273 of 1473. Image
Binding antibody titers (MSD) were also significantly higher (nominal alpha of 0.05) against ALL other variants of concern (Alpha, Beta, Gamma, Delta, Omicron) for mRNA-1273.214 when compared to mRNA-1273. Image
The mRNA-1273.214 50 μg booster dose was well-tolerated in the 437 study participants. The safety and reactogenicity profile of the mRNA-1273.214 50 μg booster dose was similar to that of mRNA-1273 50 μg dose when these vaccines were administered as a second booster dose. ImageImage
Conclusion: “The bivalent omicron-containing vaccine mRNA-1273.214 elicited neutralizing antibody responses against omicron that were superior to those with mRNA-1273, without evident safety concerns.”
You can read more here:
•Updated COVID booster tied to strong Omicron immune response: cidrap.umn.edu/news-perspecti…
•A Bivalent Omicron-Containing Booster Vaccine against Covid-19: nejm.org/doi/full/10.10…

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More from @sailorrooscout

Chise 🧬🧫🦠🔬💉🥼🥽 Profile picture
Sep 18
Just a marten in a lab coat.
🥼🎀🧬🧫🦠🔬💉
🎨: @JellyEnvy
I hope everyone is having a good weekend! Science threads will resume tomorrow. In the meantime, be sure to check out my most recent threads on updated COVID boosters, how to get them, current variants, how vaccines work, and information regarding Monkeypox and Polio. Thank you!
Okay, so maybe that’s not all. Why? BECAUSE this lovely study just came out last week.

Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant.
•biorxiv.org/content/10.110…
Read 14 tweets
Chise 🧬🧫🦠🔬💉🥼🥽 Profile picture
Sep 16
“I trust my immune system. I don’t need a vaccine.”

Ok, I trust mine to protect me too. Which is why I trained it extensively on what the virus looks like so it can handle it.

Boxers don’t enter the ring without a plan. It’s the punch you don’t see coming that knocks you out.
The Body’s Natural Response (WITH a Caveat) ImageImage
So how do vaccines help? Vaccines can contain weakened or inactive parts of a particular organism (antigen) that triggers an immune response within the body. Newer vaccines contain the blueprint for producing antigens rather than the antigen itself. ImageImage
Read 14 tweets
Chise 🧬🧫🦠🔬💉🥼🥽 Profile picture
Sep 14
Vaccines save lives.

That’s it. That’s the tweet.
Okay, so maybe that’s not all. Why? BECAUSE this lovely study just came out yesterday.

Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant.
•biorxiv.org/content/10.110…
“Chise, isn’t this a mouse model?” Why, yes it is! But here is the great part about all of this, and I quote @notdred: “Once you repeatedly show that a biological process behaves similarly in mice and humans, it is in fact okay to trust that mouse data will reflect human data.”
Read 12 tweets
Chise 🧬🧫🦠🔬💉🥼🥽 Profile picture
Sep 12
Does COVID-19 vaccination have a protective effect against Long COVID?

Answer: YES.

“Vaccination with at least two doses of COVID-19 vaccine was associated with a substantial decrease in reporting the most common post-acute COVID-19 symptoms, bringing it back to baseline.”🧵
Published in Nature. Peer-reviewed. Sound methodology. Large sample size. Real-world data.
•nature.com/articles/s4154…
•timesofisrael.com/israeli-study-…
New research out of Israel shows that COVID-19 vaccination dramatically reduces the occurrence of Long COVID.

PLEASE NOTE the fact that this study only looks at TWO doses, NOT BOOSTERS.
Read 13 tweets
Chise 🧬🧫🦠🔬💉🥼🥽 Profile picture
Sep 9
Just a friendly reminder from a marten in a lab coat. 🧬🧫🦠🔬💉🥼🥽
🎨: @tidalcats Image
This little marten is officially BOOSTED. Well, it’s my second booster, BUT with the updated bivalent vaccine! I also got my influenza vaccine as well (that one is quadrivalent). Outside of a sore arm for two days, I didn’t really have any other side effects. Image
•Who are the boosters for?
You are eligible for the new Omicron bivalent boosters IF:
-You completed your primary vaccine series (2 doses of Pfizer or Moderna or 1 dose of J&J)
-It’s been 2 months since your last booster
-You are age 12+ (Pfizer) or age 18+ (Moderna)
Read 14 tweets
Chise 🧬🧫🦠🔬💉🥼🥽 Profile picture
Sep 4
Just a marten in a lab coat.
🧬🧫🦠🔬💉🥼🥽
🎨: @tidalcats Image
I hope everyone is having a good weekend! Science threads will resume on Tuesday. In the meantime, I am going to add onto this a short FAQ on updated bivalent COVID vaccine boosters so that you can be well informed! Let’s get started!
•Who are the boosters for?
You are eligible for the new Omicron bivalent boosters IF:
-You completed your primary vaccine series (2 doses of Pfizer or Moderna or 1 dose of J&J)
-It’s been 2 months since your last booster
-You are age 12+ (Pfizer) or age 18+ (Moderna)
Read 13 tweets

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