Self-organizing systems have been one of the most exciting recent advances in stem cell research
However, many names & classifications are used making it challenging to convey the science
We now got together as a field to provide a nomenclature framework
Out in @Nature today👇1/9
However, many names & classifications are used making it challenging to convey the science
We now got together as a field to provide a nomenclature framework
Out in @Nature today👇1/9
We focused on neural #organoids #assembloids & #transplantation
Our consensus is summarized in one simple figure (above) & a short text box 👇
Our consensus is summarized in one simple figure (above) & a short text box 👇
We delineate two types of neural organoids based on the level of guidance: unguided organoids & guided (regionalized) organoids that resemble domains of the nervous system
Assembloids are generated by combining different organoids with each other or with other lineages in a self-organizing preparation
If transplanted into animals, we refer to these human cellular systems as grafted or transplanted organoids/assembloids
We strongly recommend avoiding terms such as ‘minibrain ‘, ‘brain-in-a-dish’, ‘whole-brain organoids’ or ‘humanized animals’
In general, we recommend avoiding the attribution of advanced brain functions or properties to cellular culture systems.
Amazing group efforts with pioneers in the field:
@ArlottaLab @BateupLab @GrayCampLab @silvianeurompi Rusty Gage @Knoblich_lab @Kriegsteinlab @Mad_Lancaster @UPenn_SongMing Alysson Muotri @Inhyun_P @ReinerOrly @studerl Sally Temple @gtesta72 @TreutleinLab Flora Vaccarino
@ArlottaLab @BateupLab @GrayCampLab @silvianeurompi Rusty Gage @Knoblich_lab @Kriegsteinlab @Mad_Lancaster @UPenn_SongMing Alysson Muotri @Inhyun_P @ReinerOrly @studerl Sally Temple @gtesta72 @TreutleinLab Flora Vaccarino
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