Thread by @AlbertVilella

I'll be live tweeting the $ILMN Illumina #IGF with running commentary. I won't intend to be comprehensive with the slide deck screenshots, but cover the main headlines.

NovaSeq 6000 Dx, same as NovaSeq, but regulated FDA and CE (Europe).

6Tb in 44 hours, this hasn't changed

Infinity closes the remaining 5% of the genome that is not accessible by short-reads

Long-read human WGS assay in Q1 2023, 6-7kb N50, longest reads at 30Kb. Use cases in rare disease, as an example. Ultra-rare variants for children with fatal diseases. Second half of 2023 with an enrichment panel equivalent.

XLEAP-SBS chemistry (commercial name of Chemistry X)

XLEAP will be available on NextSeq 1000/2000 in 2024 (I got it right, I thought it was gonna be the NextSeq first). P4 flowcell 500gb.

NovaSeq X (also got the name right).

Now it will be the biggest instrument in the portfolio (physically and in specs). X and X Plus.

Up to 16 addressable lanes per run, up to 16Tb

20000 WGS per year, 2.5x more than NovaSeq

NovaSeq X Plus: 16Tb, 2X faster, 3X higher accuracy, $2/Gb
NextSeq Chemistry X in 2024

The computing power of 3x NovaSeqs. The flowcells on the screen look like Wall-E's eyes.

Summary of the two new big products, the NextSeq 1000/2000 P4 flowcell and the NovaSeq X Plus in the #ngsspecs table now (need to confirm run time and other flowcell sizes).

Nano-level precision of image scanning, 2x faster basecalling, 24 hr in NovaSeq X.

It seems the runtime is reduced from 44hr to 24hr, I may not have heard this correctly, so pending confirmation.

Variant calling on board, specs shown based on the DRAGEN 4.0 pipeline.

The Broad and deCODE have already had access to NovaSeq X. Tempus as well. Macrogen in S. Korea. $REGN Regeneron some sort of access as well.