Thread by @DrGrimaldesJ

"White gold" is not only used to exploit economically and technologically, but also for the benefit of health.🌎

PREVENT COGNITIVE IMPAIRMENT AND PROLONG LONGEVITY WITH #LITHIUM, benefits: ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
frontiersin.org/articles/10.33…

1. Humans in areas with higher amounts of lithium in drinking water live longer; ncbi.nlm.nih.gov/pmc/articles/P…

2. In the long term, lithium can help maintain longer telomeres; news.ki.se/longer-telomer…

3. Lithium has been shown to regulate genes related to healthy DNA structure;

ncbi.nlm.nih.gov/pmc/articles/P…

4. Lithium appears to slow the rate of brain aging; ncbi.nlm.nih.gov/pmc/articles/P…

5. People with higher lithium intake show better mood;
GSK-3 is an enzyme that plays an important role in regulating metabolism. pubmed.ncbi.nlm.nih.gov/27068460/

6. By itself, lithium extended fruit fly lifespan by an average of 11%; Y
Combined with two other compounds, lithium extended fruit fly lifespan by an average of 48%; ncbi.nlm.nih.gov/pmc/articles/P…

7. Increases the density of gray matter and increases the size of the amygdala and hippocampus. Li is also known to stimulate the production of neural stem cells and has protective effects against oxidative stress and its consequences; frontiersin.org/articles/10.33…

8. Lithium, in trace amounts, such as in drinking water, has been inversely associated with suicidal and homicidal assault and violence. ncbi.nlm.nih.gov/pmc/articles/P…
🌊Map of Lithium in Drinking Water in the United States usgs.gov/media/images/r…

@DrLBoominathan @davidasinclair @agingdoc1 @renesugar @ @drmarkhyman @LewisHowes

#IDEAS💡
#MechanisticTherapy of Li suggestion

Can long-term lithium intake cause kidney damage?

Microdosed lithium has been shown to slow aging and exert several protective effects on cells, especially brain cells.

That's why microdosed lithium is often used as an anti-aging supplement. cdnsciencepub.com/doi/abs/10.113…
pubmed.ncbi.nlm.nih.gov/21301855/

journals.sagepub.com/doi/10.1177/07…

pubmed.ncbi.nlm.nih.gov/29103043/

ncbi.nlm.nih.gov/pmc/articles/P…

or as a way to reduce the risk of Alzheimer's disease and other neurodegenerative diseases pubmed.ncbi.nlm.nih.gov/22746245/
pubmed.ncbi.nlm.nih.gov/21525519/
pubmed.ncbi.nlm.nih.gov/26402004/

➡️LITHIUM AND KIDNEY FUNCTION
However, some people are concerned about the effects of lithium on kidney function. They read that a common side effect of long-term lithium treatment is kidney dysfunction.

It's true that long-term use of lithium can cause kidney damage

or problems with fluid balance/urine secretion (eg, diabetes insipidus), but this only applies to doses that are hundreds of times higher than microdoses of lithium.

These very high doses of lithium are given in a psychiatric setting (often to stabilize mood). These doses are in the range of 1,200 mg of lithium carbonate per day or more (sometimes even more than 2,000 mg per day), which equates to around 120 mg of pure lithium per day.

😉 Lithium in microdoses is 120 times lower.

The daily amount of lithium in NOVOS Core is approximately 120 times less than the daily amount of lithium used as medicine.

In this very low dose range, lithium in microdoses does not cause kidney damage or dysfunction🙄

[but it is logical that given a certain amount of time a lithium test should be carried out ("not in the blood" for obvious reasons) as is done for any other supplementation 🤷‍♂️

In fact, microdosing lithium may actually protect against kidney damage🤔

👀This shouldn't be surprising, because microdosed lithium increases several proteins and transcription factors (eg, Nrf2, brain-derived growth factor) that protect cells, including kidney and brain cells.

In fact, these studies show that in these regions life expectancy is usually longer and that there is an association between lithium intake and physical and mental health 🏃‍♂️🧠 pubmed.ncbi.nlm.nih.gov/29103043/
pubmed.ncbi.nlm.nih.gov/7511924/
https://t.co/sui1E5Ujid
pubmed.ncbi.nlm.nih.gov/1699579/

📚You can find more studies on lithium below:

✔️ Low-dose lithium absorption promotes longevity in humans and metazoans. Eur J Nutr, 2011
✔️Lithium traces in Texas tap water are negatively associated with all-cause mortality and premature death. Appl Physiol Nutr Metab, 2018

✔️ Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem, 2009
✔️Lithium promotes longevity via GSK3/NRF2-Dependent hormesis cell representative, 2016

✔️ Lithium microdose treatment stabilized cognitive decline in patients with Alzheimer's disease. Curr Alzheimer Res, 2013
✔️ Association of lithium in drinking water with the incidence of dementia. JAMA Psychiatry, 2017

✔️Effects of Li on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans. The Journals of Gerontology, 2014
✔️Disease-modifying properties of long-term Li treatment for amnesic mild cognitive impairment: randomized controlled trial. Br J Psychiatry,

✔️Li treatment and risk of dementia in adults with bipolar disorder: population-based cohort study. Br J Psychiatry, 2015
✔️ Is Li a neuroprotective agent? Ann Clin Psychiatry, 2015
✔️Li microdose treatment stabilized cognitive decline in patients with Alzheimer's disease, 2013

✔️ Lithium microdose treatment stabilized cognitive decline in patients with Alzheimer's disease. Curr Alzheimer Res, 2013
✔️ Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing death by apoptosis. Stroke, 2003

✔️ Chronic lithium treatment reduces mutant tau protein aggregation in a transgenic mouse model. Journal of Alzheimer's Disease, 2003
✔️Lithium in standard and trace doses: a systematic review of dementia prevention and other behavioral benefits. Aust NZJ Psychiatry, 2014

✔️ Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders. ACS Chem Neurosci, 2014
✔️Influence of lithium treatment on serum and CSF GDNF concentrations in patients with early Alzheimer's disease. 2011

✔️Li-induced neuroprotection is associated with epigenetic modification of the specific BDNF gene promoter and altered expression of apoptosis-regulating proteins. Front Neurosci, 2015
✔️A new look at an old drug: neuroprotective effects and therapeutic potential of Li salts.

#Lithium-induced neuroprotection involves increased expression of miR-124, reduced abundance of the RE1-silencing transcription factor, and decreased protein deubiquitination by pathways independent of GSK3β inhibition
pubmed.ncbi.nlm.nih.gov/27126323/

ahajournals.org/doi/10.1161/ST…

🧬miR-124 plays a beneficial role by regulating autophagy, neuroinflammation, oxidative stress and apoptosis, neuronal excitability, neurodifferentiation, Aβ deposition hyperphosphorylation of the tau protein.

✅possible regulation mechanisms of microRNA-124 🧬:

✔️inhibition of apoptosis by activating the JAK2/STAT3 signaling pathway and its downstream anti-apoptosis protein Bcl-2.

✔️phosphorylation of tau protein through regulation of the PI3K/AKT/GSK-3β signaling pathway

✔️modulation of apoptosis, autophagy, inflammation, oxidative stress and neurogenesis through negative regulation of Bim, AMPK, STAT3, ANAX5 and caspase3

✔️inhibits neuronal excitability and prolongs onset latency by inhibiting the expression of CREB1, C/EBPα and Bcl2L13

mdpi.com/1422-0067/21/1…

Preclinical studies have shown the neuroprotective potential of lithium in neurological diseases such as Parkinson’s disease, traumatic brain injury, Alzheimer’s disease, and ischemic stroke by affecting individual downstream signaling cascades.

Lithium triggers and inhibits distinct signaling pathways and effector proteins, leading to acute and long-term neuroprotection under ischemic stroke conditions.
pubmed.ncbi.nlm.nih.gov/33907010/#&gid…

@UnrollHelper