1/x 🧵 ***NEW RESEARCH *** from @EdinburghUni. The paper is relevant for the #immunocompromised and #evusheld and #forgotten500k. It really acts as a WAKE UP & ACT call. It a good paper. thelancet.com/journals/lance… Image
2/x What's the background? The pandemic continues. 👾Some people are at excess risk and can't hug loved ones, see family or enter normal life 😢. We all believe they are the #immunocompromised, but what does the data show? 💻 Image
3/x This data looked at 16 208 600 vaccined individuals across England🏴󠁧󠁢󠁥󠁮󠁧󠁿, Scotland🏴󠁧󠁢󠁳󠁣󠁴󠁿, Ireland 🇮🇪 and Wales 🏴󠁧󠁢󠁷󠁬󠁳󠁿. i.e. EVERYONE. From Dec 8, 2020, and Feb 28, 2022, so it includes the OMICRON ERA, so relevant. Risk was very carefully defined.
4/x What did they find? 👇🫢. For a few significantly higher risk. nearly 6x for the immunocompromised. Also risk for those with more comorbidies, and this includes those with immunocompromised disease. But if you survive, you are proteted for 9ms... Image
5/x More detail now. Here's the risk table. we call it a forest plot. The red dot represents risk 🔴. The lines represents uncertainty. Adjusted risk is at the bottom, 0-25x. I've added orange boxes- 🟧 , for the #immunocompromised. Image
6/x. What do they say? 👇 Image
7/x Anything else they found? If you add in age, particularly above 70, then the risk climbs. Previous risk factors like ethnicity, deprivation, BMI, urban/rural no longer drive risk. #immunocompromised DOES! @SGriffin_Lab Image
8/x Why does this matter? There are half a million immunocompromised people in the UK. Many are still shielding, still in isolation, still unable to work, see friends or hug loved ones. They are #forgotten500k, unheard and calling on us to notice. Image
9/x Prophylactic antibody therapies like #evusheld give back an “immune” system to those who are immunocompromised. It is given in a similar way to a vaccine and it prevents infections. Studies from Israel/France/US show it is working well, even against omicron Image
10/x 32 countries are delivering additional levels of protection this winter to protect immunocompromised patients who have not responded to the coronavirus vaccine, using new therapies, not available in the UK- prophylactic antibody therapies. Image
11/x Thanks to patients, clinicians @AlexRichter3 @ProfBMT + myself as champions, the clinical community has also sprung into action. Patients, 125 clinicians from 17 medical specialities & 4 nations are bringing online professional organisations/charities for a call to action.
12/x No one is sure if DHSC will offer protection or consider a pilot to protect #immunocompromised patients with #evusheld this Winter. Budgets might be an issue. However, patient power has seemingly swung into action. They are asking in mass about what they need. @hughesthenews Image
13/x We are yet to know if the data will be actioned, or levers pulled by @DHSCgovuk. Thank you to @EdinburghUni for another amazing hard hitting article putting a microscope to the risk to the population from COVID-19 and #immunocompromised. #Tourdeforce.

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More from @drlennardlee

Oct 19
1/x 🧵 Regarding #Evusheld on Bupa. I am *BEYOND SHOCKED*. If you are immunocompromised with cancer, autoimmune disease, kidney disease or on immunocompromised want COVID protection, you won't get it on the NHS. Your only choice is to go to private healthcare 🏥 #forgotten500k Image
2/x It feels wrong that if you are #immunocompromised and wealthy 💸, then you will get coronavirus protection, BUT... if you are #immunocompromised and poor 🪙👛, you can't. This is going to cause equality based on how much you earn. This doesn't feel right or British. 🇬🇧 Image
3/x Thanks @EnnalsEthan for unshielding this tactic to have covid protection only in the private, but not NHS. #immunocompromised patients just want to hug loved ones and see family 🫂. Do they have a valid choice? Does health need you to be rich? BIG QUESTIONS. @libdemdaisy Image
Read 4 tweets
Oct 19
1/x 🧵 Regarding Evusheld on Bupa. It makes me sad that if you are immunocompromised with cancer, autoimmune disease, kidney disease or on immunocompromised want COVID protection, you won't get it on the NHS. Your only choice is to go to private healthcare. 🏥 Image
2/x It feels wrong that if you are #immunocompromised and wealthy 💸, then you will get coronavirus protection, BUT... if you are #immunocompromised and poor 🪙👛, you can't. This is going to cause equality based on how much you earn. This doesn't feel right or British. 🇬🇧 Image
3/x Some hope? Maybe @RobertJenrick has not yet to be tested and maybe he might see the right solution here. After all, HEALTH 💪should be for all, COVID PROTECTION 🧑‍🚀should be for all, COMPASSION should be for all 🫂. This ad from today now seems much most apt👇👇🙁😢 Image
Read 4 tweets
Oct 19
1/x 🧵A friend sent me this asking what is this about? I found out. This is the story of what led to to this most public and most significant direct patient plea to @RobertJenrick I have not seen this EVER happen before. #forgotten500k Image
2/x It's coming from the 500,000 who are immunocompromised who are at risk from COVID-19. Still unable to work, see friends or hug loved ones. They are #forgotten500k, unheard and calling on us to notice. They have collected donations to ask for help from power. Hence all the ads Image
3/x They want protection that has been given to 32 other countries, but decision making has been stalled in the UK. They would like prophylactic antibody therapies to prevent them getting unwell with COVID as cases rise. Image
Read 8 tweets
Oct 17
The #IAPYPL are delighted to welcome you to our global event at the #WHS2022 and hear the 21 outstanding leaders below 40. The event harnesses leading minds to advance sound policies. It is tomorrow- 18th CEST 11am-1230pm worldhealthsummit.zoom.us/j/84849331333 Image
Young physician leadership for United Kingdom, me to safeguard #immunocompromised Image
Young physician leadership for Phillippines- healthcare integration and leadership Image
Read 11 tweets
Oct 17
1/x 🧵 ICYMI, the largest UK health campaign has just kicked off today. For the #immunocompromised in the UK, young and old, those with cancer, @bloodcancer_uk, autoimmune disease, transplants and kidney disease. And it's making a huge splash. I've been asked to comment.
2/x What's the background? There are half a million immunocompromised people in the UK. Many are still shielding, still in isolation, still unable to work, see friends or hug loved ones. They are #forgotten500k, unheard and calling on us to notice.
3/x Health campaigns are rare . Rarely are patients so motivated to demand action from MPs like @RobertJenrick. They are a minority, facing a niche issue, which is easy to dismiss. It's even worse if you can't leave the house because you are still shielding. How are you heard?
Read 12 tweets
Oct 16
1/x 🧵Worried to be thrown into a big Berlin protest #whs2022. I am here for #immunocompromised patients and learn about better covid prevention. Now there’s protester glued to the buildings, shouting 😡 at the 3500 conferences attendees about climate change. Police have arrived.
2/x This all is not good. Global collective approaches are essential. People must talk. Leaders must talk. Then there should be action. When people don’t feel there is transparency and have to protest, something has gone DEEPLY wrong.
3/x There must be DEEP trust and transparency in leaders. We must bring the public with us and explain the pros and cons. There should not be closed doors. These are key messages that the @IAPartnership are pushing and trained us to deliver. Protests=failure
Read 7 tweets

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