1/8 Most influential stewardship papers presented at #IDWeek2022. 1. Women in rural settings MORE LIKELY to get antibiotic treatment for uncomplicated UTI for a duration longer than recommended by guidelines, compared with urban settings. pubmed.ncbi.nlm.nih.gov/33622432/
2/8 Why does this matter? "Each day of antibiotic therapy was associated with 4% increased odds of experiencing an adverse event." pubmed.ncbi.nlm.nih.gov/34775072/
3/8 ED specific urine antibiogram, UTI guideline, education, department specific feedback followed by re-education & provider specific feedback -> initial 15% improvement in guideline-concordant abx followed by additional 3% improvement Q2wks during study. pubmed.ncbi.nlm.nih.gov/35100621/
4/8 Seven month remote telehealth prospective audit and feedback, guideline and order set management, and staff education -> 63% reduction carbapenem, 20% reduction FQ, 18% reduction vanco, 9% reduction LOS. All lost when contract not renewed. pubmed.ncbi.nlm.nih.gov/34153104/
5/8 "ASPs with successful reductions in consumption of targeted antibiotics may not see changes in infection rates with antibiotic-resistant organisms in the 2 to 6 years post-implementation." But things also didn't get worse. pubmed.ncbi.nlm.nih.gov/32667983/
6/8 Opt-Out Protocol for Antibiotic De-escalation in Patients with Suspected Sepsis -> "more antibiotic discontinuations, similar DOT when antibiotics were continued, and no evidence of harm." pubmed.ncbi.nlm.nih.gov/36167851/
7/8 Fantastic machine-human collaboration. Machine learning approach reduced prospective audit & feedback reviews in half with good sensitivity on the cases left to review. A clinical pharmacist on the unit or a formal ID consult reduced utility of PAF. pubmed.ncbi.nlm.nih.gov/35873287/
8/8 Seven days equivalent to 14 days for GNR bacteremia, INCLUDING with discharge from ED on oral therapy. pubmed.ncbi.nlm.nih.gov/34508886/
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