Nate Shively Profile picture
Oct 22 16 tweets 11 min read
What drives physicians refusing ASP recommendations?

We looked into it.

Just got done presenting our #IDWeek2022 oral abstract.
#IDTwitter

🧵

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First, there are a bunch of ways to do TeleASP, but especially the more "intense" models have shown success and can be as good as on-site programs.

Our prior work: academic.oup.com/cid/article/71…

SCORE trial from @E_Stenehjem et al.: academic.oup.com/cid/article/67…

#IDWeek2022

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What do we know already about what influences rec acceptance?

Summary of prior work, including great work from @BRxAD - surgeons tend to be less accepting, and recs that reduce antibiotic exposure refused more.

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This study adds data for TeleASP and for adult inpatients in the US.

#IDWeek2022

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Structure of the program (ID doc review with non-clinical pharmacist -> recs to primary team).

30 months of data and variables we tracked, including physician characteristics, for which there's less data.

#IDWeek2022

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We gave a lot of recommendations, and acceptance rate overall was great.

#IDWeek2022

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But what variables mattered?

Whether there was an APP involved and whether we spent one on one time with the physician explaining the program didn't.

#IDWeek2022

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On univariable analysis, those surgeons didn't look great. Neither did pulmonologists or private practice PCPs.

But in multivariable, no longer significant.

#IDWeek2022

8/ ImageImage
So what was significant?

✅ Female > male
✅ Type of rec mattered - stop/discontinue = lower odds of acceptance

And the big one:
21+ years experience = lowest odds of acceptance

(I'll come back to CCM in a minute)

#IDWeek2022

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Some thoughts on why the meeting wasn't important - we empowered local pharmacists and they became a trusted local resource.

Actually this is great - if the ID docs don't need to be on site, a given TeleASP can have more impact without geographic limits.

#IDWeek2022

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We did find that recs to limit antibiotic use led to lower acceptance. Makes sense.

But specialty wasn't significant in multivariable.

Why?

#IDWeek2022

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Because years of experience seemed to be more important.

Maybe the surgeons/private practice PCPs/pulmonologists trended toward older and male.

#IDWeek2022

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Of course have some limitations, one of which is low n of CCM docs, one of whom was super engaged - so wouldn't generalize our CCM findings.

#IDWeek2022

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Final thoughts - this might help us think about who could use some extra ASP education or targeted intervention.

#IDWeek2022

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And thanks to my co-authors, our @AHNtoday ASP team, and the HVHS pharmacists.

@TomWalshMD13 @matthewmof31 @canigetazpak @dnbrems @DustinRCarr @cbuchananpharm @CessnaPharmD

#IDWeek2022

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Full study is now published.

academic.oup.com/ofid/article/9…

#IDWeek2022

16/16

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More from @NateShivelyMD

Oct 22
Oral Therapy for Bacteremia and Endocarditis

@IDwithNWD giving talk for @BradSpellberg

"No, you're not in the wrong room, and @BradSpellberg did not get younger and more handsome."

#IDWeek2022
#IDTwitter
Historical lesson first.

Where did the myth that we need IV for IE come from?

Have to go back a ways.

#IDWeek2022
The dooming quote.

#IDWeek2022
Read 12 tweets
Oct 21
What's better for reducing unnecessary treatment of asymptomatic bacteriuria? Diagnostic stewardship or antibiotic stewardship?

@ValerieVaughnMD presenting the @SHEA_Epi featured oral abstract.

#IDWeek2022 ImageImage
Pathway to overuse and opportunities to intervene.

#IDWeek2022 Image
Diagnostic stewardship metric was ASB (treated or not) / +UCx

#IDWeek2022 ImageImage
Read 8 tweets
Oct 21
Bactrim is fine for most beta-hemolytic strep, folks.

Many of us were taught this one incorrectly because thymidine content in agar unregulated until 2006 so looked resistant in old studies.

Appreciate @SDoernberg clearing this one up in 2nd myth busters talk.

#IDWeek2022 ImageImageImageImage
Nice aside - dosing matters.

Most people I'm consulted on who fail oral treatment for true cellulitis are underdosed.

#IDWeek2022 Image
Clinical data on PCN vs TMP/SMX and Clinda vs TMP/SMX.

#IDWeek2022 ImageImageImageImage
Read 4 tweets
Oct 21
Nice follow up talk from @ValerieVaughnMD - always great stuff from her.

#IDWeek2022 Image
Anyone ever seen a patient like this?

(For hospitalists like @ValerieVaughnMD and those of us that review patients with ASP, every day, multiple times per day)

#IDWeek2022 ImageImageImageImage
A note that what we call overdiagnosis for infections, others may call inappropriate diagnosis.

#IDWeek2022 Image
Read 8 tweets
Oct 21
I don't know anyone that is more excited about urine than @Sonali_Advani.

Some highlights from her great talk this morning ⬇️

#IDWeek2022
Lots of factors go into inappropriate culturing.

Physicians more driven by labs, nurses by appearance/smell.

Education can help.

#IDWeek2022
Tough group is the 3rd box.

Yep.

#IDWeek2022
Read 9 tweets

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