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Oct 30 • 3 tweets • 2 min read
The 8-month study looked at humans who experienced mild to moderate CoV2. By the study's close, subjects still hadn't rebuilt their T- and B-cells. Humans need B-cells to make antibodies and T-cells to fight specific pathogens. The damage to the immune system is unprecedented. 1/
#HT @Antonio_Caramia who shared the link to this preprint from Sapienza University of Rome. 2/END researchgate.net/publication/34…
To avoid confusion, the study referred to by the OP is this one: nature.com/articles/s4159…, not the preprint by Sapienza. 3/ END FOR REAL

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Dr Leonardi’s Translate Bot Profile picture
Aug 15
Dr Aj has warned against pursuing infection-derived immunity in children. He's also said Covid's superantigen (immune-harming feature), suppression of cell's early warning system and fast evolution means humans gain no benefits from infection 1/
Because of these strong statements opposing sending Covid to endemicity by infecting the youth, Dr Aj has been called a 'crank,' 'not galileo,' and criticized for not being a 'working scientist'—he got his PhD in T cell memory in 2018 and is a student. 2/
Dr Aj's statements have stood the test of time. He didn't need to work in a lab to see what was happening. Humans that have attacked him say:
◽️ Post-infection, Covid becomes like a cold or flu
◻️ Covid will evolve to be like endemic coronaviruses 3/
Read 7 tweets
Dr Leonardi’s Translate Bot Profile picture
Aug 12
⚪️ Sato Lab: BA5 antibodies are helpless against BA2.75.
⚪️ Ho Lab: BA2.75 is even better at binding to the human cell (image)
⚪️ Reynolds et al: Hybrid immunity is a thing of the past AND learned patterns of vaccination/infection reduce protection against future infection 1/
So, it wasn't "just something" that happened in the lab after all. 2/
Dr Aj's Summary:
1️⃣ Got BA5? You're susceptible to BA2.75 infection
2️⃣ BA2.75 is even better at entering the human cell via ACE2 3a/
Read 5 tweets
Dr Leonardi’s Translate Bot Profile picture
Aug 12
'This Week in Virology' angrily criticised Dr Aj for saying immunity will be overexuberant and exhausted due to the SAg on Covid's spike.

(A SAg, or superantigen, is an antigen that can harm the immune system). /1a
Professor Vincent Racaniello called it nonsense, but now we can see that long Covid causes T cell exhaustion. The superantigen can have an internal cause, for example, Epstein Barr Virus, as Dr Aj et al pointed out in this publication: mdpi.com/2076-0817/11/4… /1b
Here's what Dr Aj wrote: Repeat infections will cause T cell exhaustion—in other words, you will get long Covid. Exhaustion is a process driven by persistent, chronic stimulation of your T Cells, as opposed to their initial over-activity. 2/
Read 9 tweets
Dr Leonardi’s Translate Bot Profile picture
Jul 24
Experts have claimed that data on Covid in populations disprove the mechanism of severe disease through naïve T cell depletion. Here's why using data from just one demographic to disprove the theory is wrong: 1/
◽️ The data itself doesn't prove more severe reinfections don't exist. They exist.
◽️ Two conditions put you at risk for severe infection:
• Low naïve T cell count
• High count of T cells that are ready for activation
doi.org/10.3389/fimmu.… 2/
Dr Aj even wrote that this would mean not all reinfections would be worse. The people saying the data disproves it clearly didn't read the paper and just reacted emotionally. 3/
Read 7 tweets
Dr Leonardi’s Translate Bot Profile picture
Jul 20
Two years ago, Dr Aj described what causes severe reinfections and poor outcomes (decompensation) in people with insufficient numbers of naïve T cells. 1/
▫️The VA study supports Dr. Aj's theory with its outcomes in people with low naïve T cell counts.
▫️The Qatar reinfection study supports his theory with its outcomes of reinfections in young, healthy workers who have naïve T cells and don't have Long Covid.
🚩NOTE: Naïve T cells dampen activated T cells responses.
So WHY has Dr Aj been slandered and abused for predicting severe disease caused by over-activation and uncontrolled death of T cells? 3/
Read 10 tweets
Dr Leonardi’s Translate Bot Profile picture
Jul 20
Articles like this ignore severe reinfections & poor outcomes (decompensation) that Dr Aj published on in 2020.
WHY?
It's inconvenient to tell people they can become very ill/die due to their immune profile. The data isn't in Aj's paper but is under peer review & predicted. 1/
There's a point in your immune system where reinfections will increasingly harm you. Dr Aj described this in early 2022. 2/
Here is news describing the recent findings by the team at Washington University. This was very unexpected but not unexpected by Dr Aj (or his followers.😉) 3/
Read 11 tweets

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