Lazarus Long Profile picture
Nov 5, 2022 19 tweets 10 min read Read on X
Another absolutely horrible take by #FireWalensky, @CDCgov

“If you go two years without getting that infection, without getting that protection from infection and then all of a sudden, boom, everybody from zero to three years gets RSV, you see the impact on health care.”
Except. That's NOT WHAT the data shows

As we can see, the biggest spike is in 0 to 6 months, and in comparison to 2018-2019, it is much greater. Roughly, per 100k, 130 versus 70, and it is still spiking.

Second biggest spike is in 6 to 12 months, at almost 80, versus 30 at
its highest.

In the 1 to 2 year olds, almost 40 this year vs. almost 20.
(The Y-axis is higher this year because of more cases).

If what Walensky is saying was true, we'd expect to see the 2 to 4 year olds screaming higher.

It's not.
But the big hitter was the zero to 6 months. What happened there?

Walensky's immunity silliness simply is irrelevant.

But this is relevant:
She really will do everything in her power to minimize CoVid, won't she?

Free version of that article here!
archive.ph/gRg9p

RSV dashboard is here - play with it, see what else you can find

cdc.gov/rsv/research/r…
This is Jose Romero, director of the NCIRD at the @CDCgov.

Jose is not thinking clearly. Has he been infected?

Why do I say he's not thinking clearly?
At the most recent CDC briefing, Jose was asked, why RSV is spreading so quickly and early.
"So we’re seeing more RSV because in the last past two years, we’ve not seen infections in children as we have previously. And so these children, if you will, need to become infected to move forward because it’s a disease very common in children. "

Literally, the XKCD comic.
But the same problem exists.

The biggest spike in hospitalizations is in the babies. 0-6 months and 6 months to 2 years. And the 0-6 months was the BIGGEST spike.

What could cause hospitalizations in that group?

Well, first what causes RSV hospitalizations?

"Pre-F antibody titers were significantly lower in mothers whose infants were hospitalized with RSV bronchiolitis compared with those mothers whose infants were not hospitalized..."

academic.oup.com/jid/article/22…
So, maternal antibodies are important. Could the maternal antibodies have not been passed on because the mother did not get infected?

Fortunately, 95% of people are exposed by the time they are two, so the mother would not have had to be exposed to pass on those antibodies.
Can you imagine?

"Now that you are pregnant, let's schedule your infections. First trimester, we'll do RSV and Ebola."

Silliness.

Let's take another look at that preprint that @fitterhappieraj found

Every infant inherits their microbiome from their mom, and mom's
microbiome diversity was reduced by Covid.

And we know those infants had a unique microbiota, per above, compared to Covidians (those infected).

Indeed, SARS-CoV-2 infections during pregnancy are associated with a compromised initial microbial seed of the infant.
No big deal, right?

Wrong.

"The inherited microbiome exerts marked effects on immune programming with long-term health consequences, including susceptibility to infections or chronic inflammatory diseases and reduced vaccine efficacy"
"Therefore, this “window of opportunity” at birth, either renders infants with a healthy immune system or alternatively establishes a divergent path leading to severe immune-mediated disease susceptibility (16-24). "

Well, that sounds like pediatricians are going to be busy.
To be crystal clear, this study is NOT saying that Covid is responsible for the increase in RSV.

But it is saying Covid causes negative changes at a very important moment in the baby's life, immunologically speaking.

And since we are talking about more severe RSV cases?
It seems to be directly related.

Or, at the very least, much more plausible than a concept invented last year. A concept that Fox & Friends has been pushing.

Was it bleach they last pushed? Or herd immunity?

In any event, both Walensky and the director of the CDC are also
pushing immunity debt like universities pushing student loan debt.

Someone needs #FireWalensky, and put Jose on notice.

@CDCgov? That microbiome spoiled once #FireWalemsky got hold of it.

Maybe probiotics could save the #xkcdCDC. Maybe.
The RSV surge in the 0-6 month old babies, which eliminates "immunity debt/gap" as a viable hypothesis?

Will have very real consequences down the road. This is not surprising given measles ability to wipe out immune memory

frontiersin.org/articles/10.33…

H/t @Gene_PHL @Comm_in_Care

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More from @LazarusLong13

Apr 18
Trump is trying to distract from the economy. He just pumped out the Lab Leak from the official whitehouse.gov website.

Simultaneously making masking advocacy both more difficult and easier.

The Shrodinger Presidency. If only he had.... /+

whitehouse.gov/lab-leak-true-…
Of course I don't wish him dead in a box. That is against Twitter's TOS.

But, anyway, what do I mean? On the one hand, pointing out that Covid is probably a bioweapon means that you can point out the silliness of not protecting yourself against it.

On the other hand, this: Image
Which, of course, is silly as workers in BSL2-4 labs wear N95s and better to protect against bioweapons.

Heh. I can tell an antimasker wrote that because they screwed up the logic on it.

Mask mandates do NOT equate masks.
Read 6 tweets
Apr 2
@TheAtlantic @danengber Heh - I suspect Mr. Engber has been eavesdropping on my (and my fellow Covid Conscious) swimming safer threads. I have a new solution for showering safer for that I will be rolling out tomorrow.

For future articles by those who will come along, let me point out a few things /+
@TheAtlantic @danengber Thank you very much for pointing out that 4% of America is still masking 100% of the time! That is 13.2 million Americans.

The Masking Nation is larger than 38 states. :)

But, 18% of us masking some of the time in the SAME PEW POLL (tch tch). You would think that would be/+ At a basic level, their COVID-conscious attitudes may not be so far from the mainstream. Twenty-one percent of Americans still think of the disease as “a major threat” to public health, according to a recent poll from Pew Research Center. Thirty-nine percent say we’re not “taking it seriously enough.” But if 50 million to 100 million adults harbor such concerns, very few are doing much about them. Masking rates were once as high as 88 percent; now they’re close to nil. For those who still maintain their masking habit—4 percent, says Pew—the whiplash in social norms has been a shock.
@TheAtlantic @danengber be mentioned, @TaylorLorenz, by Mr. Engber, since 18% lines up pretty closely to the 21% still worried that Covid is a big deal (it is) - that he mentioned.

And suddenly, Masking Nation has 59.4 million residents. We are the largest state. Canada /+

Read 14 tweets
Mar 22
This may be one of the most important studies in a decade.

#LongCovidBinder.

"The models produced correctly classified those with severe ME/CFS from recovered controls with an accuracy of 97%, sensitivity of 94%, and specificity of 100%. "

THAT IS HUGE.
"We found that at Stage 1, those fated to develop ME/CFS 6 months following IM had low levels of IL-5 and IL-13 [25]. " We found that at Stage 1, those fated to develop ME/CFS 6 months following IM had low levels of IL-5 and IL-13 [25]. IL-5 enhances the production of B1 cells which are anti-inflammatory (impaired B1 cells have been found in multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis), and IL-13 has anti-inflammatory properties. Jason et al. [26] also found that students who failed to recover from IM had more restricted, inflexible cytokine networks whereas those who recovered had more flexible, less interconnected networks. Network analysis suggests that IL-5 and IL-13 influe...
So, this means ME/CFS can be predicted.

And what can be predicted - treatments can be found.

And they are studying LongCovid as well.

This study is easy to read, And everyone should.

/+

mdpi.com/2076-2607/13/4…
Read 6 tweets
Mar 13
A new study just showed what I have been saying since the start of bird flu. H5N1 is airborne.

Still in place?
USDA: YOU ONLY NEED TO TEST LACTATING COWS.

oops.

USDA: FOMITES (infectious objects) SPREAD IT.

oops.

WASHING YOUR HANDS WILL STOP IT.

oops. This new Federal Order does not override or supersede USDA's April 24 Federal Order, which still requires the mandatory testing of lactating dairy cows prior to interstate shipment and requires that all privately owned laboratories and state veterinarians report positive test results connected with those tests. The new Federal Order announced today is intended to complement and enhance this existing order.
Question [00:51:52]  Given the CDC's vaccination program, I'm wondering if this means you think it's no longer realistic to expect that the outbreak will be contained this year?  Eric Deeble, USDA [00:52:12]  Just on the animal side and all that Dr. Nirav speak to the human side, there's a lot about this disease that makes us feel as if we can arrest its progress.  And we've actually seen some success demonstrated to date.  With this disease, it does not appear to move by respiratory transmission. We know that there are high viral loads in milk, and we've identified through close, collabora...
In addition to testing, biosecurity is the key to containing this virus, and ultimately ensuring that it is eradicated so that producers do not have to deal with this virus in dairy cattle permanently. Good biosecurity including cleaning and disinfection of vehicle and equipment - is critical to minimizing the risk of disease spread. USDA works closely with state animal health official, producers, and industry organizations to provide guidance and resources for cleaning and disinfection not only on affected farms but for all livestock producers as a part of practicing good biosecurity. APHI...
The study.

✅ 20% of the cows showed up as sick. Had symptoms. But....

✅ It turns out that 89.4% were actually infected.

✅ 83.7% of those had no symptoms. Remind you of any other airborne diseases?

✅ 40.5% of the dry cows not being milked? Infected. So, no Image
Image
Image
fomites or milk aerosols involved, most likely.
Read 6 tweets
Mar 13
There is not much that scares me. Freaks me out.

I am freaking out.

You should be, too.

Do you know what this shows?

Do you know how to avoid this? Holy cow.
This is the continued accumulation of dementia-causing microplastics in your brain. Simple linear regression (shown with 95% CI represented by dashed lines) was performed for total plastics, polyethylene, polypropylene, polyvinyl chloride and styrene-butadiene rubber measured in normal decedent brains from 2004 (average of east coast samples), 2016 and 2024 (NM OMI samples).
See how it increased from 2016 to 2024?

And it actually is worse - they found less plastics in brains from a decade earlier.

ACCUMULATION. Simple linear regression (shown with 95% CI represented by dashed lines) was performed for total plastics, polyethylene, polypropylene, polyvinyl chloride and styrene-butadiene rubber measured in normal decedent brains from 2004 (average of east coast samples), 2016 and 2024 (NM OMI samples).
Read 28 tweets
Feb 23
Great interview of Ed Yong - I am just covering the C0V1D part.

/1 The Interview  Ed Yong Wants to Show You the Hidden Reality of the World  Ed standing with his arms folded.  His eyes tell you COVID is not over.
You've been clear in saying that C0V1D has not gone away. You ask people to wear masks at your events..... You’ve been clear in saying that Covid has not gone away. You ask people to wear masks at your events. But that attitude is not necessarily where the rest of the world is. How do you think about continuing to take precautions and advising others to do so when it feels as if society has moved on? I do it for a bunch of reasons. Firstly, I have learned that I enjoy not being sick. I know that the cost of long Covid is real and substantial, and I don’t want to run that risk lightly.
"I think it makes a huge difference to them to have the person at the front of the stage wear a mask. It tells them, It’s not weird." . I also know that I have many friends and people I’m close to who are immunocompromised. So for the sake of the people around me, I also don’t want to get sick. When I do events, I wear a mask for those reasons, and because I know that every time I do a talk, while the vast majority of people in the audience have probably moved on, there are going to be other people who haven’t. I think it makes a huge difference to them to have the person at the front of the stage wear a mask. It tells them, It’s not weird. So I do it for that reason, too. In terms of holding this line at a point when a l...
Read 5 tweets

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