This is a nice academic review that misses the boat on massive demyelination following lymphatic overflow hardening at the cranial occipital base. cell.com/neuron/pdf/S08…
They missed the spike protein encephalitis/myelitis of Omicron BA.1. They underestimate brain infection through hypothalamic fenestrations and through brainstem vagus nerve nuclei fenestrations.
They miss CSF penetrance of lipid-coated nanoparticle mRNA into the lateral ventricles. They missed the brain surface 'meningitis' of Omicron BA. 5 variants.
If we didn't have a pandemic with urgency to protect the brain from permanent damage and cachectic degeneration of function ... I could teach a whole semester off of this remarkable, up-to-date, science review.
Inhaled budesonide would have prevented half or more of the neuro-immunological pathology elegantly and clearly depicted here.
Great doctors need to palpate.
You would have found lymphatic drainage pouring down the back of the cervical spine where lymph vessels were unknown. You would have found this drainage spreading out now under and into the trapezius muscle and down the thoracic spine.
#Threadreaderapp Dear Bot! Elonfuscate this wretched, mangled $50 Billion Train of Thought: unroll this spool
If it doesn't prevent infection, if it doesn't stop transmission, if it prevents serious complications for less than 10 week... can we get back to "TREATMENT" and allow doctors to resume independent clinical decision-making? nature.com/articles/s4146…
Will President Biden issue a proclamation? "No federal agency and no state licensing board shall henceforth restrict a doctor's freedom to discuss, obtain informed consent, and treat patients at all stages of Covid-related illness to the best of their abilities. "
Will it take an act of Congress to restore a licensed physician's right to practice ?
18 y.o. I've seen since age 11 wants to come in urgently. He's getting violent imagery when angered and it makes him sad. His heart feels tight and starts pounding - and right away there is pounding in his head.
Do you pick a psych med or examine the patient first?
He hasn't been in the office for nine months. Is a telemedicine session going to be enough?
@ZekeEmanuel@Bob_Wachter@BenMazer Dr. Mazur is right that important stages of these illnesses are apparent at 4 weeks, 8 weeks, and 12 weeks after the initial onset of symptoms. Examining patients regularly - something forgotten by technology-dependent graduates of academic medical institutions - shows that.
@ZekeEmanuel@Bob_Wachter@BenMazer Each wave of Covid-19 distributed illness in particular patterns of pathognomonic signs evident on physical exam.
@ZekeEmanuel@Bob_Wachter@BenMazer So there is no "Medium CoviD". There have been five infection patterns each with different organ and tissue impacts.
Today's case: 17 y.o. sick Jan.-Feb. 2022 and asymptomatic in June when both parents caught covid presents with 'mapping' of small intestine on the right, a little stiffness of upper right liver, inter-hemisphere heat in the middle of his forehead and both brainstems glued.
Some tightness of lower occiput - flat on the left, harder & round on the right. 5 weeks ago kicked through a door at home and taken to the hospital; released in the morning pt. Has been on good behavior since then. Calm in the office but not talking today. What week post-acute?
Covid BA.5 is resolving: frontal heat & swelling is down. Liver stiffness releases with 2 minutes of mechanical percussion. No swelling of intestine. No temporal swelling, heat or flattening. Estimate: 8-12 weeks post-acute Omicron BA.5.
To me it seems possible that, in MECFS/long-covid, the continued production of spike protein alone...various spike proteins...viral spike-induced epigenetic dysregulation of human spike proteins...could lead to persistent disruption of collagen matrix signaling and realignment.
Based on how quickly the entire thorax turned rock-hard in 2020 I thought spike oligomers ( spike stacking on spike like Legos) was most likely. These oligomers dispersed easily with percussion - consistent with weak polymer bonds.
Then the Spike-Angie video appeared and the syncytial glue this mixed polymer created was clearly far stronger than salt and hydrogen bonds.
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues ncbi.nlm.nih.gov/pmc/articles/P…
It is hard to explain how an mRNA molecule can continue to produce spike protein for 5-15 days without some amplification by vaccine components or without cell nucleus penetration and genetic incorporation.
Once we are counting in trillions it becomes clear that infection with Covid-19 could produce enough polymer to wrap the liver, lungs, heart, kidneys and brain ... in 'Saran Wrap'.