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Nov 12 • 3 tweets • 4 min read
#ACR22 #ACR2022
12S110. Plenary I - 0003
Rituximab versus Cyclophosphamide for the Treatment of Connective Tissue Disease Associated Interstitial Lung Disease (RECITAL): A Sub-group Analysis of a Multi-centre Randomised Controlled Trial
HOT OF THE PRESS
thelancet.com/journals/lanre…
#ACR22 #ACR2022
12S110. Plenary I - 0003
RECITAL TRAIL
CYC = RTX
PS: only 1 dose (Day 1 and 14) dose of RTX given
No other IS allowed
CYC>RTX in IIM
RTX>CYC in SSc
#ACR22 #ACR2022
12S110. Plenary I - 0003
RECITAL TRAIL
Individual disease responses

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More from @ERheumat

EnvisionRheumat Profile picture
Nov 13
#ACR22 #ACR2022
12S129. Purple Peripheries: Vasculopathy VS Vasculitis
Philip Seo is awesome as always
The most common cause is Cardiovascular followed by Rheumatic
More commonly vasculopathy than Vasculitis ImageImageImageImage
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12S129. Purple Peripheries: Vasculopathy VS Vasculitis
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Nov 13
#ACR2022 #ACR22
12S130. Rheumatology Secrets and Pearls
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🎯RA may present with asymmetric arthritis
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12S130. Rheumatology Secrets and Pearls
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🎯Puffy fingers may be the first sign of SSc in RNApolIII SSc and No Raynaud's - May present with SRC
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Nov 13
#ACR2022 #ACR22
12S130. Rheumatology Secrets and Pearls
Jason Kolfenbach, with his wonderful pearls
1. Vasculitis Pearls
🦪For Steroids ➡️ Less is more
🦪Be very careful in stopping Rx in AAV pts
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🦪Not all Skin thickening = SSc
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🦪30% SLE pts have APS
🦪DLE uncommonly progresses to SLE
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Nov 12
#ACR2022 #ACR22
12S102. Year in Review 👌🏻
1st to be discussed was the Gloria Trial
Glucocorticoids effective but safety an issue ImageImageImage
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12S102. Year in Review 👌🏻
Next to the most discussed study of the year
Oral surveillance trial
The CV risk is higher in those with ASCVD - NNH 16😳 ImageImageImage
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12S102. Year in Review 👌🏻
Next to the Proderm Study
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Jun 6
#EULAR2022
What is New (WIN)
IgG4
🔆IgG4 is a multi-organ Disease
🔆usually >50
🔆M:F - 3:1
🔆CD4+ cytotoxic cell implicated
🔆 Classification criteria known
#EULAR2022
What is New (WIN)
IgG4
🔆➕ve correlation with smoking (IgG4 retroperitoneal fibrosis)
🔆 blue Collar Jobs have ⬆️IgG4 (pancreato biliary)
🔆d/t toxic exposures 👉🏻 asbestosis, mineral dust
#EULAR2022
What is New (WIN)
IgG4
🔆Role of AutoAb suspected
🔆Anti-IL1RA👉🏻Mediates Inflammation and fibrosis
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Jun 6
#EULAR2022
Pain in rheumatic and musculoskeletal diseases
😩Pathophysiology of pain in patients with RMDs is not always Nociceptive and can be nociplastic
😩Differentiation between inflammation-related and unrelated pain is important
#EULAR2022
Pain in rheumatic and musculoskeletal diseases
😩Pain can be Nociceptive, Neuropathic and Nociplastic
😩Or can be primary/Secondary
😩Pain sensitisation, processing and response are important for proper assimilation of pain
#EULAR2022
😩No standard method to measure central pain
😩FMS can be present in upto 50% of patients
😩Asso with Higher disease activity and higher biologic use/change
😩A no. of central mechanisms contribute to pain
Read 7 tweets

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