High-order dynamics in brain networks & dementia are not well-captured by connectivity. We developed a new framework of high-order interactions (3-to-N plets) with information theory + greedy algorithm in #fMRI - #EEG across #AD & #FTD Paper doi.org/10.1016/j.nbd.… & 🧵👇1/5
High-order functional connectivity (HOFC) at 3-15 plets yielded networks with large effect sizes for both modalities (fMRI and filtered EEG) and comparison (CN vs. AD, CN vs. FTD). Results included decorrelated networks for fMRI and EEG but also hyperconnectivity. 2/5
The fMRI/EEG characterization of neurodegeneration revealed hypo/hyperconnectivity on high-order interactions. Regions such as the amygdala, the insula, and the frontal gyrus were associated with both effects, suggesting more complex processes in hub regions. 3/5
HOFC is robust against the influence of age, education, and motor artifacts (fMRI head movements and EEG eye artifacts), as revealed by multivariate analyses. Classification accuracy was comparable with standard biomarkers. 4/5
From political unrest to toxic air and social stress, the world around us can accelerate the aging process. Out today in @NatureMedicine: our work on how the environment seeps into health and makes us older
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The Biobehavioral Age Gap (BBAG) in 160,000+ people (40 countries) compares the real age to an estimated age from protective (education, functionality, cognition, wellbeing, physical activity), & risk factors (heart disease, diabetes, hearing/visual deficits, weight)
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Accelerated aging varied worldwide, with Northern and Western Europe experiencing the healthiest aging, Africa the worst, and Latin America + Asia in between. Accelerated aging was linked to lower income, poor air and social quality, and, importantly, weaker democracy
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