Thread by @TactNowInfo

🧵"Senescence, the process of being disposed of by the immune system or persisting in an altered, dysfunctional condition. With the immune system no longer functioning effectively, this leads to the onset of chronic infections, cancerous disease,& death."

nature.com/articles/s4146…

COVID Accelerated Aging (CAA)

"T- cells, like other cells, have telomeres that shorten with each cell division (telomere attrition). When telomeres reach a critical length, the cell stops dividing and enters senescence."

nature.com/articles/s4146…

> 5 YEARS of Aging from COVID

"results show a consistent biological age increase in the post-COVID-19 population, determining a DeltaAge acceleration of 10.45 ± 7.29 years (+5.25 years above the range of normality) "

mdpi.com/1422-0067/22/1…

"Critically short telomeres impair the regenerative capacity of tissues and trigger loss of tissue homeostasis and disease. The SARS-CoV-2 virus infects many different cell types, forcing cell turn-over and regeneration to maintain tissue homeostasis."

ncbi.nlm.nih.gov/pmc/articles/P…

Compared to noninfected controls, cumulative risks of repeat infection increased according to the number of infections

Every reinfection contributes additional risk

3 infections worse than 2

2 infections worse than 1

1 infection worse than none

nature.com/articles/s4159…

#CAA

Reinfection increased the risk of

Diabetes
Fatigue
Kidney problems
Mental health disorders
Musculoskeletal problems
Neurologic disorders
Lung problems

nature.com/articles/s4159…

#CAA

"direct damage of lymphoid tissues and apoptosis of lymphocytes, are presumably the primary causes of the profound lymphopenia observed in patients infected with SARS-CoV-2)."
nature.com/articles/s4157…

#CAA

"Infection can cause severe damage to the TEC compartment, by either inducing apoptosis or accelerating terminal differentiation"

" Depletion of the adult TEC progenitor pool can cause permanent disruption of the thymic stromal microenvironment"

link.springer.com/article/10.100…

#CAA

COVID bypasses antibodies. COVID can infect T-cells and damage the thymus, the heart of our immune system.

"COVID infection of T cells, in a ACE2-independent manner, shows the underlying mechanisms of COVID induced lymphopenia"

nature.com/articles/s4139…

#CAA

COVID infects Neutrophils

"This study highlights the independent role of neutrophils in contributing to the aberrant immune responses observed during SARS-CoV-2 infection that may be further dysregulated in the presence of other immune cells"
mdpi.com/2227-9059/10/2…

#CAA

COVID is attacking our immune system.
Guess what else infects T-cells? MERS (34% fatality rate)

"Lymphocytopenia was also found in MERS cases. MERS-CoV can directly infect human primary T lymphocytes and induce T-cell apoptosis through extrinsic and intrinsic apoptosis pathways"

BQ.1.1 defeats all available monoclonal treatments & paxlovid.

Even if initial symptoms are milder due to the limited immune response, people will have a higher risk of long term persistence, including in the brain.

COVID can infect astrocytes via NRP1 interaction, ..

COVID can infect astrocyte cells, in the brain and central nervous system & secondarily impair neuronal function & viability.
"Our study comes as a cautionary note that mechanisms of neuroinvasion in fatal COVID-19 could also be operative in mild COVID "

pnas.org/doi/10.1073/pn…

" Cortical thickness atrophy after mild COVID-19 infection."

"Structural and functional alterations in the brain tissue of COVID-19 patients, which parallel in vivo findings of cortical atrophy, neuropsychiatric symptoms,& cognitive dysfunctions."

pnas.org/doi/10.1073/pn…

#CAA

All of this is important to understand so that we can reduce the risk & impact on families and communities.

We must get the message out that this disease is dangerous even if it presents as milder.
The slow burn of damage is causing strokes, heart attacks,& shortening lives.

There is a reason that deaths from all causes is spiking dramatically higher than the average from previous years.

The countries that relaxed mitigations first show the faster pace of all cause deaths increasing. COVID is killing people months after initial infection.

#CAA

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