Alexandre Freitas Profile picture
Nov 19 10 tweets 12 min read
It is not true that only a subset of the immunocompromised or a subset of the Long Haulers has viral persistence. A preliminary analysis of the papers in this compilation (data up to July 2021) 🧵1/6

shows 2,669 cases on SARS-CoV-2 persistence, with only 240 cases (9% of the total) showing symptoms in the last positive sample (up to ~7 months from symptoms onset) and only 109 cases (4% of the total) out of those 240 could be classified as Long COVID. 2/6
Of these 2,669 cases of viral persistence, only 113 (4,2% of the total) are immunocompromised.

As of July 2021, more cases of Long COVID should appear in the papers, even so, from what I remember from the papers, this pattern should remain. 3/6
This is overwhelming evidence that the virus persist in anyone who becomes infected and that while a part has already developed symptoms of Long COVID, the rest may still show these or other symptoms. 4/6
While they make everyone think that “the virus persists in a very unfortunate subset of the infected”, hundreds of millions of people who think they are “recovered”, are actually already at risk of developing disabling/life threatening diseases in the coming years 5/6
and hundreds of millions more could join this group. It’s past time for us to have really effective antiviral treatments against SARS-CoV-2. Enough is enough! 6/6

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More from @FreitasABR

Jun 30
"We detected SARS-CoV-2 RNA in 30% of colon liquids collected from previously infected patients who had asymptomatic infections or who had recovered from mild infection, with one sample testing positive 5 months after the patient’s COVID-19 diagnosis" 🧵(1/3)
-All patients without symptoms since “recovered”.

-All underwent routine screening colonoscopy.

-All had viral nucleocapsid protein in epithelial cells in the colonic crypts (active viral replication in the GI tract) (2/3)
“Our analyses clearly demonstrated that persistence of SARS-CoV-2 in the GI tract is relatively common” (3/3)
Read 6 tweets
Jun 22
-SARS-CoV-2 evades NK cell cytotoxic responses. 🧵 (1/9)

SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D

biorxiv.org/content/10.110…
-role of NK cells in mediating clearance of SARS2-infected cells in vivo remains unclear. Several studies have demonstrated that NK cells can reduce the levels of SARS2 replication in vitro, no prior study has directly evaluated killing of SARS 2 infected cells. (2/9)
-NK cells exhibit poor cytotoxic responses against SARS2-infected targets, preferentially killing uninfected bystander cells.

-NK cells may actually cause damage to the healthy tissue surrounding infected cells rather than clearing the infection. (3/9)
Read 11 tweets
May 28
"Of the 15 children who had severe COVID-19, 7 had developed encephalitis as a result of the disease, as had 5 of the 6 children who died". "Some experts said that the proportion of severely ill children in Taiwan with encephalitis is 'unusually high'.”

breakinglatest.news/world/the-epid…
"To date, 16 children under the age of 10 have developed severe symptoms after contracting COVID-19, according to the Central Epidemic Command Center (CECC).

7 of those children died, including 5 who developed encephalitis"

focustaiwan.tw/society/202205…
"So far 20 cases of severe cases in children have been reported, including 9 cases of encephalitis, in severe cases, there have been a total of 10 deaths including 5 cases of encephalitis. are quite tall."

todaynationnews.com/medical-analys…
Read 17 tweets

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