Medical Doctor, @FMUSPoficial, SARS-CoV-2 Researcher.
Nov 19, 2022 • 10 tweets • 12 min read
It is not true that only a subset of the immunocompromised or a subset of the Long Haulers has viral persistence. A preliminary analysis of the papers in this compilation (data up to July 2021) 🧵1/6
shows 2,669 cases on SARS-CoV-2 persistence, with only 240 cases (9% of the total) showing symptoms in the last positive sample (up to ~7 months from symptoms onset) and only 109 cases (4% of the total) out of those 240 could be classified as Long COVID. 2/6
Jun 30, 2022 • 6 tweets • 10 min read
"We detected SARS-CoV-2 RNA in 30% of colon liquids collected from previously infected patients who had asymptomatic infections or who had recovered from mild infection, with one sample testing positive 5 months after the patient’s COVID-19 diagnosis" 🧵(1/3)
-All had viral nucleocapsid protein in epithelial cells in the colonic crypts (active viral replication in the GI tract) (2/3)
Jun 22, 2022 • 11 tweets • 11 min read
-SARS-CoV-2 evades NK cell cytotoxic responses. 🧵 (1/9)
SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D
biorxiv.org/content/10.110…
-role of NK cells in mediating clearance of SARS2-infected cells in vivo remains unclear. Several studies have demonstrated that NK cells can reduce the levels of SARS2 replication in vitro, no prior study has directly evaluated killing of SARS 2 infected cells. (2/9)
Jun 7, 2022 • 19 tweets • 6 min read
Thead: Intra-host evolution in IMMUNOCOMPETENT patients.
(Under construction)
"Of the 15 children who had severe COVID-19, 7 had developed encephalitis as a result of the disease, as had 5 of the 6 children who died". "Some experts said that the proportion of severely ill children in Taiwan with encephalitis is 'unusually high'.”
breakinglatest.news/world/the-epid…
"To date, 16 children under the age of 10 have developed severe symptoms after contracting COVID-19, according to the Central Epidemic Command Center (CECC).
7 of those children died, including 5 who developed encephalitis"
-study with 46 inflammatory bowel disease patients 219 days (94-257) after COVID19.
-SCoV2 RNA in the gut mucosa ∼7.3 months after mild COVID19 in 32 of 46 patients.
-viral N protein persisted in 24 of 46 patients in gut epithelium and CD8+ T cells.
