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You May Be Early, but You're Not Wrong: A Covid Reading List, by @JessicaLexicus
open.substack.com/pub/jessicawil…
Yesterday, I came across a somber tweet by a man who’s trying to protect his family from Covid. He said, “my wife has been speaking with the principal of my children’s elementary school and that he has been advising her to file for divorce because..my life revolves around fear”2/
"Yes, a principal is telling someone’s wife to divorce him because he wants to protect them from a deadly, disabling virus.

"Companies are also starting to pressure their employees to get therapy “to conquer their fear of Covid.”

3/
There’s a line from the film The Big Short that echoes through my head..The investor Michael Burry says, “I may have been early, but I’m not wrong.” There’s a lot of us who feel like that right now. A majority of the world thinks we’re crazy. In reality, we’re not crazy at all.4/
"We have the facts.

"Over the last few months, there’s been an avalanche of studies telling us that Covid poses a major threat to our health, our lives, and our sanity. The biggest risk now comes in the weeks and months after we recover.

5/
"Our politicians and media have done a poor job communicating this threat. Instead, they’re doing their best to manipulate information to protect their own political interests. The public has bought into these lies. They want to believe they can return to normal.

6/
"The latest studies tell us that’s not possible.

"There’s no permanent immunity from this virus. Each time we catch it, this virus attacks our hearts and minds. It weakens us. It tries to kill us. It imprints on us, so a future variant has a better shot next time.

7/
"Here are the key points:

1. You can catch Covid multiple times.
2. Reinfections are common, not rare.
3. Breakthrough infections are common.
4. Covid can kill you months after you recover.
5. It can cause brain damage.
6. It can cause blood clots and heart attacks.

8/
7. It doesn’t spare children.
8. Vaccines help, but only some.
9. Masks work.

"Everyone should know about these studies.

9/
"I’ve linked to the original articles. I’ve tried to summarize them in clear language. I’ve also linked to summaries written by journalists who still care about the truth.

Here they are:
10/
“Long-term neurologic outcomes of COVID-19,” Nature Medicine, 2022.

"Researchers at Washington University built a giant data set of veterans to look at the long-term impact of Covid on people’s nervous systems.

11/
"They found that anyone who gets Covid can develop problems with memory, concentration, depression, migraines, and even strokes. They’re not temporary. Some people slowly get better. A lot of them don’t.

12/
"Catching the virus elevates your risk of memory problems by 77 percent. It elevates your risk of stroke by 55 percent. It elevates your risk of seizures by 80 percent. That’s because Covid attacks the lining of your blood vessels, and it attacks your brain cells.

13/
"Worse, the researchers can’t predict risk factors.

"That means it can happen to anyone, even if you had a mild case. As the head researcher has explained, “We’re seeing brain problems in previously healthy individuals and those who have had mild infections…

14/
"It doesn’t matter if you are young or old, female or male, or what your race is. It doesn’t matter if you smoked or not, or if you had other unhealthy habits or conditions.”

"Key takeaway: Anyone can get Long Covid.

"You don’t want it.

15/
“Long COVID after breakthrough SARS-CoV-2 infection,” Nature Medicine, 2022

"The same researchers from Washington University tried to find out exactly how much vaccines help prevent Long Covid. In general, vaccines reduce your risk by about 15 percent. So, not much.

16/
"The head of the research team says.. our current approach is going to have a big impact on our way of life.. “This will not only affect people’s health, but their ability to work, life expectancy, economic productivity and societal well-being.

17/
"We need to have a candid national conversation about the consequences of our current approach.”

"Key takeaway: Vaccines help, but not as much as everyone thinks.

"It’s better not to keep getting Covid.
18/
“SARS-CoV-2 promotes microglial synapse elimination in human brain organoids,” Molecular Psychiatry, 2022.

"Medical researchers from Sweden and Boston teamed up to find out what Covid does to your synapses,.. They saw a major reduction in synapses after a Covid infection.

19/
".. infected mini brains showed ..similar to the level seen in neurological disorders like schizophrenia, Alzheimer’s, and Parkinson’s disease.” In other words, your brain starts killing off those..connections that help your brain cells communicate.

20/
"That’s why a third of people who get Covid wind up having problems thinking and concentrating later.

"Key takeaway: Covid eats your brain.

"Don’t catch it.

21/
“Excess risk for acute myocardial infarction mortality during the COVID-19 pandemic,” Journal of Medical Virology, 2022

"Researchers .. looked at the effect Covid has on heart attacks. They found a huge 34 percent increase in young people (25-44 years old), caused by Covid.
22/
"These were previously healthy people with no preexisting conditions.. It includes “mild” Omicron infections. The authors admit it’s like nothing anyone has seen before.

"Key takeaway: Covid can kill healthy young people.

"It’s giving them heart attacks.
23/
“Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection,” Nature Immunology, 2022.

Researchers ..compared blood samples from healthy patients to ones with Long Covid. The Long Covid patients all had deficits in T and B Cells.
24/
"In fact, they were missing T cells completely. Basically, Covid can deplete your immune system’s long-term memory. Nobel-prize immunologist..discusses. study, saying it explains a lot.

Key takeaway: Covid attacks your immune system.

You don’t develop immunity.

You lose it
25/
“ACE2-independent infection of T lymphocytes by SARS-CoV-2,” Signal Transduction.. 2022.

..researchers..teamed up to look at the same question about Covid’s impact on our immune systems. They found the same troubling outcome: The virus can exhaust your T Cells,
26/
"..either killing them or making them go haywire. As they say, “T lymphocytes.. underwent pronounced apoptosis compared to those from the healthy donors, showing a more than tenfold increase of apoptotic cells.” In case you’re wondering, apoptosis means cell death.
27/
"Those T Cells also helped carry the virus to other parts of the body, acting like a subway for Covid.

Key takeaway: Covid kills T Cells.

It makes you more vulnerable to other diseases.

You don’t want that.

28/
“Distinguishing features of Long COVID identified through immune profiling,” Preprint/Yale, 2022.

"Researchers at Yale took up the same question as the previous two studies, since it’s a pretty controversial idea. They found the same thing.

29/
"Covid can damage your T Cells and trigger autoimmune disorders. Writing for The Tyee, Andrew Nikiforuk sums it up this way: “exhausted T cells that suggested the patients were fighting an active chronic infection.”.. read that Nikiforuk piece.

30/
thetyee.ca/Analysis/2022/…
"Key takeaway: Every Covid infection runs a risk of weakening your immune system. It can even reactivate old viral infections.

Avoid it at all costs.

31/
“Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure,” Science, 2022.

". their findings shoot down the popular myth spread by mainstream media that getting Omicron would provide some kind of long-lasting immunity. It doesn’t.

32/
"Like other studies are showing, we’re not building herd immunity.

"Key Takeaway: One Covid infection sets up another.

"We’re not building immunity.

33/
“COVID-19 and Acute Neurologic Complications in Children,” Pediatrics, 2022.

"..looked at the impact of Covid on children, from infants to teenagers. They found that 7-8 percent of hospitalized kids went on to develop severe neurological problems, including seizures.

34/
"In short,.kids all wound up with major brain damage.. this isn’t temporary. It’s going to stay with them for years, and it’s probably going to haunt them for the rest of their lives.

Key takeaway: Children aren’t safe from Covid.

They need protection.

35/
“Post–COVID-19 Conditions Among Children 90 Days After.. Infection,” Pediatrics, 2022.

Researchers.. teamed up to look at Long Covid in hospitalized children. They found that up to 9.8 percent of them went on to experience chronic symptoms like severe fatigue and weakness, 36/
".similar to what adults go through..

Studies like these.. disprove the popular myth that children are somehow safe from Covid. They’re not. In fact, the researchers describe the risk as “consistent with studies in adults.”

Key takeaway: See above.

Children aren’t safe
37/
“Long-COVID in children and adolescents: a systematic review and meta-analyses,” Nature Scientific Reports, 2022.

".. review 21 studies on Long Covid in children. They found that 25 percent of children experience chronic symptoms that include mood and sleep disorders,
38/
"..along with fatigue. Once again, kids aren’t immune to Covid. They get just as sick as adults. It didn’t look or feel that way because we were protecting them.

"Key takeaway: See above.

Children aren’t safe from Covid.

They need protection.

39/
“Post-COVID-19-associated morbidity in children, adolescents, and adults..” PLOS Medicine, 2022.

.. compared. rates of Long Covid in children and adults. They found something troubling. About a third of children who get Covid go on to develop long-term symptoms like..adults. 40/
"..Children don’t die as often, but they experience some of the same chronic symptoms..

"Key takeaway: Covid isn’t like a cold.

"Children shouldn’t catch it.

41/
“Lifting Universal Masking in Schools ..” The New England Journal of Medicine, 2022.

..what happened in Massachusetts schools when they lifted mask mandates. ..29.4 percent more cases in the 15 weeks ..authors conclude that masks work.

Key takeaway: Masks work.

Wear them. 42/
“Acute and postacute sequelae associated with .. reinfection,” Nature Medicine, 2022.

.. what happens when you get infected with Covid over and over. They found “cumulative risks and burdens of repeat infection increased according to the number of infections.”

43/
"As the other studies in this list show, catching Covid doesn’t boost your immunity. It just increases your risk of death, hospitalization, brain damage, mental illness, strokes, and heart attacks.

Key takeaway: If you got Covid once, you’re not in the clear.

It’s not over.
44/
"Biggest takeaway: the media lied to us.

The evidence is overwhelming now.

Last winter, the media made a concerted effort to convince Americans that Covid had become mild. They said catching Omicron would protect us from future variants, and that we could ditch our masks. 45/
"Newspapers were filled with op-eds basically telling us to go out and shop, celebrate, and get infected. They blanketed the internet with stories about the “relief” people felt catching Covid.

Anyone who disagreed got labeled a doomsayer.

The optimists were all wrong.

46/
"There was no evidence to support any of these myths, just arrogant assertions from the same handful of pundits. The actual studies tell the truth. You don’t want to catch Covid once. You certainly don’t want to catch it multiple times. We should be getting boosted.
47/
"We should be wearing masks.

We should be protecting our children.

There’s only one alternative, and that’s catching Covid over and over until it destroys our immune systems, along with our hearts and minds.

Nobody wants that.

48/

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More from @yaneerbaryam

Nov 19
The Twitter implosion is a chance to rethink information sharing/collaboration. We invite you to join a new mastodon server at forall.social — As usual in mastodon, following to other servers is possible. We look forward to enhancing community efforts.

1/ Image
Let me know if you are interested in tutorial meetings to move over. We are setting them up.

2/
Before Musk, while Twitter provided important benefits of shared global dialog, it fostered gangs of bots & trolls acting against individuals. This was and isn’t reasonable. Twitter’s attempts at enforcing rules of engagement were not adequate as they didn’t solve the problem. 3/
Read 11 tweets
Nov 14
Update: There appears to be good news on Ebola in Uganda. Yesterday there was one reported case and none in the previous 4 days. There were only 7 cases in the past 13 days. Reported cases have decreased in the past 3 weeks.

I will post the situation report from yesterday.
Yesterday's report shows 1 new case, and 4 new recoveries. Either cases grow exponentially or decrease exponentially, so more recovered than new cases is good news for outbreak control. Unfortunately there is also one new death. Total deaths 55 of 139 cases (not all recovered)
2/
Page 2 has the plot I showed first. Note 1,127 contacts are being followed up. With this number of cases, contact tracing can stop an outbreak. For more than 10 new cases per day, the number of contacts rapidly becomes overwhelming. Numbers also given for district/county. 3/
Read 7 tweets
Nov 4
TV report is truth: "It impairs the immune system, which means that after COVID is done and gone, you are more susceptible to other kinds of infections, and that may well be a bigger problem in children."

1/
h/t @greg_travis
edmonton.ctvnews.ca/more-than-12-0…
"So we're seeing a lot of respiratory illness, far more than could be accounted for in any other way.”

"It jolts us back into reality and the reminder that we're still in a pandemic”

2/
"I think they've abandoned us under this guise of back to normalcy. We know it's not normal. We're dealing with illness upon illness but no help is there.”

3/
Read 4 tweets
Nov 3
Consensus statement to recommend specific actions to #endCOVID19 as a global threat to public health

Multidisciplinary panel of 386 academic, health, NGO, government, & other experts from 112 countries/territories.

Article in @nature
Link: go.nature.com/3NtcfCM
1/
In the wake of nearly three years of fragmented global and national responses,.recommendations call for. whole-of-society.approaches, while maintaining proven prevention measures .that employs a range of public health and financial support measures to complement vaccination. 2/
"As of Sept 2022, more than 620 million cases of COVID-19 and over 6.5 million deaths have been reported, although mortality estimates range as high as 20 million..Highly transmissible variants continue to spread globally, while surveillance.remains largely inadequate 3/
Read 7 tweets
Oct 30
New paper: Modeling Complex Systems: A Case Study of Compartmental Models in Epidemiology

"Our purpose is to show how assumptions can constrain model outcomes to a narrow portion of the wide landscape of potential epidemic behaviors.

@AlexSiegenfeld

hindawi.com/journals/compl…
"The key to good modeling is understanding which details matter and which do not. Paradoxically,... the impossibility of getting all the details right may discourage a careful analysis of which assumptions are appropriate in which contexts.
"In an attempt to obtain better predictions, it may be tempting to include more details and fine-tune the model assumptions. However, arbitrarily focusing on some assumptions and details while losing sight of others is counterproductive.
Read 4 tweets
Oct 30
Advisory for the state of Karnatka, India, that borders on Maharashtra, due to first BQ.1 detected in Maharashtra

Proactive: testing and self-isolation, seeking medical care, masking, outdoor festivals, vaccination,..

1/
hindustantimes.com/cities/bengalu…
1. Get tested immediately if you show symptoms
Residents are instructed to get tested immediately at their nearest hospital or healthcare centre if they show symptoms of fever, cough, cold, sore throat and breathing difficulties.

2/
2. Self-isolate
Those who are symptomatic should isolate themselves until negative results are received.

3/
Read 7 tweets

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