Thread by @biosectinvestor

Exploring Adjuvants with #DCVaxL: POLY ICLC TLR 3 Agonist adjuvant discussion, #DrLindaLiau, early trial P 1. Using adjuvants w/ #DCVaxL $NWBO #Murcidencel #DCVax

Survival Data w/Adjuvants, small early trial:

Fuller Discussion re early trial with #DCVaxL + adjuvants, including Poly ICLC:

Re single agent checkpoint inhibitors, without DCVaxL, in Glioblastoma:

This is a paper from 2010, presenting the early Adjuvant data Phase 1, and patients were both nGBM and rGBM, so not all the same. #DCVaxL Poly ICLC, a TLR 3 Agonist.

See Table 1, therein, for specifics on which patients were which:

ncbi.nlm.nih.gov/pmc/articles/P…

Follow-up Paper on Phase 1 patients, including nGBM and rGBM, as well as Glioma patients, #DCVaxL + various adjuvants.

CTIM-18. DENDRITIC CELL VACCINATION IN CONJUNCTION WITH ADJUVANT TLR-3 AGONIST ADMINISTRATION ENHANCES PRO-INFLAMMATORY IMMUNE RESPONSES AND IS ASSOCIATED WITH EXTENDED SURVIVAL IN MALIGNANT GLIOMA PATIENTS , November 2020 academic.oup.com/neuro-oncology…

This is a larger and ongoing follow-up adjuvant trial: Larger #DCVaxL #Adjuvant trial, which is ongoing, here: clinicaltrials.gov/ct2/show/NCT01…

This is an ongoing clinical trial including #PolyICLC + #Keytruda with #DCVaxL, where DCVax-L without Keytruda is the placebo arm.

clinicaltrials.gov/ct2/show/NCT04…

And here are the final results of the #DCVaxL Phase 3 trial without any adjuvant or immunotherapy combination jamanetwork.com/journals/jamao…

These various trials and data suggest a possibility that use of Adjuvants and combination therapy with #DCVaxL could further enhance the potential for extending survival of patients with #Glioblastoma #GBM or #Gliomas.

The above JAMA Oncology paper suggests that "Treatment with DCVax-L can potentially be combined with a wide range of other treatment agents (including checkpoint inhibitors, cytokines, targeted therapies, chemotherapies, or oncolytic virus therapies)."

Approval by regulators of #DCVaxL would open up the door to a more rapid opportunity, with real world data and other advances under the 21st Century Cures Act, to evolve treatment quickly and possibly make more rapid advances in the treatment of brain tumors.

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